Periodontal disease in seropositive rheumatoid arthritis: scoping review of the epidemiological evidence

Nik-Azis, Nik-Madihah; Mohd, Nurulhuda; Baharin, Badiah; Said, Mohd Fuaad; Fadzilah, Fazalina Mohd; Haflah, Nor Hazla Mohamed

doi:10.18683/germs.2021.1263

Cited by 7 publications

(5 citation statements)

References 60 publications

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“…One of the environmental factors involved in the development of RA has been shown to be the microbiome [ 112 ]. Studies in recent years have shown a higher incidence of RA in patients with periodontal disease [ 113 , 114 ]. In addition, it has been shown that the severity of periodontal disease correlates with the activity of the disease process in RA patients and that treating the symptoms of periodontal disease results in the alleviation of RA symptoms [ 115 , 116 ].…”

Section: Oral Microbiome In Systemic Diseasesmentioning

confidence: 99%

The Role of the Oral Microbiome in the Development of Diseases

Kozak

Pawlik

2023

IJMS

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Periodontal disease (PD) is a complex and infectious illness that begins with a disruption of bacterial homeostasis. This disease induces a host inflammatory response, leading to damage of the soft and connective tooth-supporting tissues. Moreover, in advanced cases, it can contribute to tooth loss. The aetiological factors of PDs have been widely researched, but the pathogenesis of PD has still not been totally clarified. There are a number of factors that have an effect on the aetiology and pathogenesis of PD. It is purported that microbiological, genetic susceptibility and lifestyle can determine the development and severity of the disease. The human body’s defence response to the accumulation of plaque and its enzymes is known to be a major factor for PD. The oral cavity is colonised by a characteristic and complex microbiota that grows as diverse biofilms on all mucosal and dental surfaces. The aim of this review was to provide the latest updates in the literature regarding still-existing problems with PD and to highlight the role of the oral microbiome in periodontal health and disease. Better awareness and knowledge of the causes of dysbiosis, environmental risk factors and periodontal therapy can reduce the growing worldwide prevalence of PDs. The promotion of good oral hygiene, limiting smoking, alcohol consumption and exposure to stress and comprehensive treatment to decrease the pathogenicity of oral biofilm can help reduce PD as well as other diseases. Evidence linking disorders of the oral microbiome to various systemic diseases has increased the understanding of the importance of the oral microbiome in regulating many processes in the human body and, thus, its impact on the development of many diseases.

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Section: Oral Microbiome In Systemic Diseasesmentioning

confidence: 99%

The Role of the Oral Microbiome in the Development of Diseases

Kozak

Pawlik

2023

IJMS

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“…Another MR study reported an association between the prevalence of PD and an increased risk of RA, despite having only 7 eligible IVs based on their summary statistics [38] . However, these two studies have a limitation that they treat different serotypes of RA as a whole, whereas different serotypes of RA may have distinct effects on the occurrence of PD [40] .…”

Section: Discussionmentioning

confidence: 99%

Genetic causal association between rheumatoid arthritis and periodontitis: a bidirectional two-sample Mendelian randomization analysis

Cheng,

Gao,

Huang

et al. 2024

Clin Oral Invest

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BackgroundA link between rheumatoid arthritis (RA) and periodontitis (PD) has been established. However, their causal relationship remains unclear and the effect of different serotypes of RA on the PD development has not been investigated. This study aims to elucidate the causal association between PD and different serotypes of RA using Mendelian Randomization (MR). MethodsA bidirectional two-sample MR analysis was performed using available large-scale genome-wide association studies statistics. The inverse-variance weighted (IVW) or multiplicative random-effects IVW was used to determine causality, depending on the heterogeneity of instrumental variables. Additional sensitivity analyses were also performed. ResultsThe forward MR analysis identi ed that seropositive RA [odds ratio (OR):1.26, 95% con dence interval (CI): 1.07-1.44, p = 0.0018], but not seronegative RA [OR:1.01, 95% CI: 0.95-1.06, p = 0.9098], was associated with an increased risk of PD. The reverse MR analysis did not show any signi cant causal effect of PD on RA, independent of the serotypes. The sensitivity tests (p > 0.05) con rmed the robustness and accuracy of these ndings. ConclusionThis study revealed that there was a genetic causal effect of seropositive RA on PD, suggesting that this subtype of RA patients may require speci c clinical attention to prevent the development of PD. What is already known on this topicPrevious epidemiological studies have suggested a link between rheumatoid arthritis (RA) and periodontitis (PD). However, the causal relationship between PD and different serotypes of RA remains unclear.What this study adds -The application of bidirectional two-sample Mendelian Randomization (bi-TSMR) analysis identi ed that seropositive RA, but not seronegative RA, was associated with an increased risk of PD.How this study might affect research, practice or policy -Clinicians should be aware of the importance of periodontal health in RA patients and consider recommending RA patients to undergo periodontal examination or treatment.

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“…It can activate citrullination enzymes in host neutrophils through pore-forming toxin leukotoxin A. Exposure to leukotoxic Actinobacillus actinomycetemcomitans was confirmed in RA patients with PD and was positively associated with ACPA levels ( 69 , 70 ).…”

Section: Clinical Application Of Acpasmentioning

confidence: 97%

Anti-citrullinated Protein Antibody Generation, Pathogenesis, Clinical Application, and Prospects

Liu

Gao

et al. 2022

Front. Med.

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Anti-citrullinated protein antibodies (ACPAs) are autoantibodies commonly observed in patients with rheumatoid arthritis (RA). Currently, most of the mechanisms of ACPA formation and bone destruction are well-understood, however, some unknown mechanisms still exist. There have been many new advances in ACPA-related clinical applications and targeted therapies. However, the existence of different ACPA subtypes is a limitation of targeted therapy. Herein, we present an overview of the process of ACPA generation, the underlying pathogenesis, and relevant clinical application and prospects.

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Periodontal disease in seropositive rheumatoid arthritis: scoping review of the epidemiological evidence

Cited by 7 publications

References 60 publications

The Role of the Oral Microbiome in the Development of Diseases

The Role of the Oral Microbiome in the Development of Diseases

Genetic causal association between rheumatoid arthritis and periodontitis: a bidirectional two-sample Mendelian randomization analysis

Anti-citrullinated Protein Antibody Generation, Pathogenesis, Clinical Application, and Prospects

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