Periodontal disease in research beagle dogs – an epidemiological study

Kortegaard, Hanne E.; Eriksen, Thomas; Bælum, Vibeke

doi:10.1111/j.1748-5827.2008.00609.x

Cited by 111 publications

(124 citation statements)

References 20 publications

(56 reference statements)

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“…5), but this correlation was not signifi cant, probably because of the small number of dogs used in the present study. Our results are in agreement with previous results that periodontal disease is the most widespread oral disease in dogs and incidence increases with advancing age (Kortegaard et al, 2008;Hirai et al, 2013). Further work is also required to confi rm this hypothesis.…”

Section: Correlations Between Vsc Levels and Agesupporting

confidence: 83%

Application of a portable gas chromatograph for quantitative measurement of canine oral malodor

Iwashita

Sugita

Shirai

et al. 2017

Fundam. Toxicol. Sci.

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-Oral malodor is an unpleasant condition experienced by most individuals around the world. Volatile sulfur compounds (VSCs) may be the main source of oral malodor both in humans and dogs. The purpose of this study was to examine the suitability for measurement of oral malodor levels in dogs using OralChroma TM , a portable gas chromatograph developed for human use. Oral malodor and periodontal disease in laboratory Beagle dogs (N = 6) were determined by organoleptic assessment and OraStrip ® test, respectively. Relatively high concentrations of VSCs in the breath were detected in all six dogs in the order of hydrogen sulfide (H 2 S) > methyl mercaptan (CH 3 SH) > dimethyl sulfide ((CH 3 ) 2 S). There was no significant influence of meals on VSCs levels. Significant correlations (P < 0.05) were observed among each VSC. These findings for the first time highlight the potential of OralChroma TM , which allows for noninvasive, rapid and quantitative measurement of oral malodor levels in dogs, and warrants further investigation.

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Section: Correlations Between Vsc Levels and Agesupporting

confidence: 83%

Application of a portable gas chromatograph for quantitative measurement of canine oral malodor

Iwashita

Sugita

Shirai

et al. 2017

Fundam. Toxicol. Sci.

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“…Periodontal disease is the most widespread oral disease in dogs and prevalence estimates of between 44% and 64% have been reported (Butkovi c et al, 2001;Kyllar and Witter, 2005;Kortegaard et al, 2008;Hamp et al, 1984). It is generally accepted that the build-up of plaque bacteria on the tooth surface causes periodontal disease, however the specific organisms involved in the initiation of disease and subsequent events are not yet known (Van Dyke, 2009).…”

Section: Introductionmentioning

confidence: 98%

A longitudinal assessment of changes in bacterial community composition associated with the development of periodontal disease in dogs

Wallis¹,

Marshall²,

Colyer³

et al. 2015

Veterinary Microbiology

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Periodontal disease is the most widespread oral disease in dogs. Whilst the involvement of bacteria in the aetiology of periodontitis is well established the role of individual species and their complex interactions with the host is not well understood. The objective of this research was therefore to perform a longitudinal study in dogs to identify the changes that occur in subgingival bacterial communities during the transition from mild gingivitis to the early stages of periodontitis (<25% attachment loss). Subgingival plaque samples were collected from individual teeth of 52 miniature schnauzer dogs every six weeks for up to 60 weeks. The microbial composition of plaque samples was determined using 454-pyrosequencing of the 16S rDNA. A group of aerobic Gram negative species, including Bergeyella zoohelcum COT-186, Moraxella sp. COT-017, Pasteurellaceae sp. COT-080, and Neisseria shayeganii COT-090 decreased in proportion as teeth progressed to mild periodontitis. In contrast, there was less evidence that increases in the proportion of individual species were associated with the onset of periodontitis, although a number of species (particularly members of the Firmicutes) became more abundant as gingivitis severity increased. There were small increases in Shannon diversity, suggesting that plaque community membership remains relatively stable but that bacterial proportions change during progression into periodontitis. This is the first study to demonstrate the temporal dynamics of the canine oral microbiota; it showed that periodontitis results from a microbial succession predominantly characterised by a reduction of previously abundant, health associated taxa.

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“…In a previous study of Beagle dogs [15] we have shown that the prevalence of both clinical attachment loss (CAL) ≥1 mm and pocket probing depth (PPD) ≥4 mm are relatively high even in younger dogs, but also that only a minority of the dogs have such clinical signs of PD in more than a few teeth. Hence, a minority of dogs carry the major PD burden.…”

Section: Introductionmentioning

confidence: 99%

“…A number of studies suggest that PD among dogs [15-18], in corroboration with PD in humans [19-21], follows a particular pattern within the dentition, which may be utilized to develop a tool for screening dogs for PD. A total periodontal disease index for disease estimation has been described; however this index aims at estimating disease extent within a dentition, not as in this present study disease occurrence within a population [22,23].…”

Section: Introductionmentioning

confidence: 99%

Screening for periodontal disease in research dogs - a methodology study

2014

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BackgroundIt has been shown that the prevalence of both clinical attachment loss (CAL) ≥1 mm and pocket probing depth (PPD) ≥4 mm is relatively high even in younger dogs, but also that only a minority of the dogs have such clinical signs of periodontal disease (PD) in more than a few teeth. Hence, a minority of dogs carry the major PD burden. These epidemiological features suggest that screening for PD in larger groups of dogs, allowing for rapid assessment of treatment planning, or for the selection of dogs with or without PD prior to be included in experimental trials, should be possible. CAL is the central variable in assessing PD extent and severity while PPD is the central variable used in treatment planning which make these two variables obvious in a screening protocol with the dual aim of disease identification and treatment planning. The main purpose of the present study in 98 laboratory Beagle dogs was to construct a fast, simple and accurate screening tool, which is highly sensitive for the identification of dogs with PD.ResultsExamination of the maxillary P4, P3, P2, I1 and C would, in this population, result in the identification of 85.5% of all dogs and 96% of all teeth positive for CAL ≥1 mm, and 58.9% of all dogs and 82.1% of all teeth positive for PD ≥4 mm.Examination of tooth pairs, all C’s, maxillary I2, M2 and the mandibular P4 would, in this population result in identification of 92.9% of all dogs and 97.3% of all teeth positive for PD ≥4 mm, and 65.5% of all dogs and 83.2% of all teeth positive for CAL ≥1 mm. The results presented here only pertain to the present study population.ConclusionsThis screening protocol is suitable for examination of larger groups of laboratory Beagle dogs for PD and our findings indicate that diseased dogs are identified with a high degree of sensitivity. Before this screening can be used in clinical practice, it has to be validated in breeds other than Beagle dogs and in populations with larger age variation.

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Periodontal disease in research beagle dogs – an epidemiological study

Cited by 111 publications

References 20 publications

Application of a portable gas chromatograph for quantitative measurement of canine oral malodor

Application of a portable gas chromatograph for quantitative measurement of canine oral malodor

A longitudinal assessment of changes in bacterial community composition associated with the development of periodontal disease in dogs

Screening for periodontal disease in research dogs - a methodology study

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