Periodontal disease in patients with ankylosing spondylitis

Pischon, Nicole; Pischon, Tobias; Gülmez, E.; Kröger, Jörn; Purucker, Peter; Kleber, Bernd‐Michael; Landau, Hans; Jost‐Brinkmann, Paul‐Georg; Schlattmann, Peter; Zernicke, Jan; Burmester, Gerd R.; Bernimoulin, Jean‐Pierre; Buttgereit, Frank; Detert, J.

doi:10.1136/ard.2008.097212

Cited by 46 publications

(75 citation statements)

References 29 publications

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“…A close association between inflammatory rheumatic diseases and infectious PD has been demonstrated in epidemiological studies [5][6][7][8]; however, limited data on pathomechanistic pathways exist [12][13][14]24,25,37]. Evidence of increased systemic bacteremia with oral pathogens has been observed in patients with inflammatory PD when compared with healthy controls [38].…”

Section: Discussionmentioning

confidence: 97%

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The Impact ofPorphyromonas gingivalisLipids on Apoptosis of Primary Human Chondrocytes

Röhner¹,

Hoff²,

Matziolis³

et al. 2012

Connective Tissue Research

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The role of oral bacterial infections including periodontal disease in the pathogenesis of rheumatoid arthritis (RA) has gained increasing interest. Among the major periodontal pathogens, Porphyromonas gingivalis has been mostly associated with RA pathogenesis. The aim of this study was to analyze the effect of P. gingivalis total lipid (TL) fraction and dihydroceramides, as potent virulence factors, on human primary chondrocytes. Primary chondrocyte cultures were incubated with P. gingivalis phosphoglycerol dihydroceramide (PG DHC) lipids, the TL fraction or phosphoethanolamine dihydroceramide. Cell morphology changes were determined by phase contrast light microscopy. Early and late apoptosis cell analysis was performed by Annexin-V, active caspases, and 7-Aminoactinomycin D staining, and examined by flow cytometry, and cell necrosis was evaluated by lactate dehydrogenase release. Procaspase-3 activation was determined by Western blot analysis. Microscopic analysis showed altered cell morphology and cell shrinkage following incubation with P. gingivalis TLs and PG DHC lipids. Flow cytometry demonstrated an increase of Annexin-V positive and active caspases positive chondrocytes after incubation with TL and PG DHC fractions but not after phosphoethanolamine dihydroceramide (control lipid) treatment or in untreated control cells. Furthermore, Western blot analysis showed an early cleavage of procaspase-3 after 1 hr. Significant lactate dehydrogenase release following incubation with P. gingivalis lipids was demonstrated. The present data demonstrate that P. gingivalis lipids promote apoptosis in primary human chondrocytes, and thereby may contribute to the joint damage seen in the pathogenesis of RA.

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Section: Discussionmentioning

confidence: 97%

“…In recent years, epidemiologic studies point to an association between PD and inflammatory rheumatic diseases such as rheumatoid arthritis (RA) [4][5][6][7][8]. RA is a prevalent inflammatory disease of the world with a prevalence of 0.5-1.0% in Western populations [9,10].…”

Section: Introductionmentioning

confidence: 99%

The Impact ofPorphyromonas gingivalisLipids on Apoptosis of Primary Human Chondrocytes

Röhner¹,

Hoff²,

Matziolis³

et al. 2012

Connective Tissue Research

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“…Additional exclusion criteria included a history of diabetes or clinical inflammatory bowel disease. Sample size estimates for the CP prevalence as a primary outcome were derived based on the previously reported results by Pischon et al 10 (at an α error of 5% and statistical power of 95%): 35.4% of patients with AS and 12.5% of controls had CP with attachment loss (AL) >3.5 mm. The study was approved by the local ethical committee (Institutional Review Board Protocol B‐1206/156‐001), and written informed consent was obtained from all participants.…”

Section: Methodsmentioning

confidence: 99%

“…In this context, CP may provide a microbial reservoir affecting the development and clinical outcomes in AS. A few studies have investigated the association between AS and CP 10–12 . Two cross‐sectional studies reported contradictory results regarding the association between CP and AS 10 , 11 .…”

mentioning

confidence: 99%

Chronic Periodontitis Is Associated With Spinal Dysmobility in Patients With Ankylosing Spondylitis

Kang

Lee

et al. 2015

Journal of Periodontology

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“…Periodontitis is related to AS to a significant degree [4], and periodontitis is significantly more prevalent in patients with AS [5]. …”

Section: Introductionmentioning

confidence: 99%

Periodontal Pathogens are Likely to be Responsible for the Development of Ankylosing Spondylitis

Öğrendik¹

2015

CRR

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The role of oral bacteria in the etiology of ankylosing spondylitis (AS) is examined in this review. Periodontitis is related to AS to a significant degree, and periodontitis is significantly more prevalent in patients with AS. Anti-Pophyromonas gingivalis and anti-Prevotella intermedia antibodies titers are higher in AS patients than in healthy subjects. Eight randomized controlled trials that used sulfasalazine were reviewed. Moxifloxacin and rifamycin are significantly effective in the treatment of AS. Periodontal pathogens are likely to be responsible for the development of AS in genetically susceptible individuals. These results will guide more comprehensive and efficacious treatment strategies for AS.

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Periodontal disease in patients with ankylosing spondylitis

Abstract: The present study shows that patients with AS have a significantly higher risk of PD, strongly suggesting the need for close collaboration between rheumatologists, periodontists and dental hygienists when treating patients with AS.

Cited by 46 publications

References 29 publications

The Impact ofPorphyromonas gingivalisLipids on Apoptosis of Primary Human Chondrocytes

The Impact ofPorphyromonas gingivalisLipids on Apoptosis of Primary Human Chondrocytes

Chronic Periodontitis Is Associated With Spinal Dysmobility in Patients With Ankylosing Spondylitis

Periodontal Pathogens are Likely to be Responsible for the Development of Ankylosing Spondylitis

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