Periodontal Disease in Patients with Psoriasis: A Systematic Review

Nijakowski, Kacper; Gruszczyński, Dawid; Kolasińska, Julia; Kopała, Dariusz; Surdacka, Anna

doi:10.3390/ijerph191811302

Cited by 7 publications

(7 citation statements)

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“…It has various subtypes; the most common is plaque psoriasis (Rendon and Schäkel, 2019). Psoriasis is associated with decreased quality of life and psychological morbidity (Nijakowski et al, 2022). Psoriasis can not be cured completely, but its sign and symptoms can be reduced using therapies such as phototherapy, topical agents, and biological and non-biological agents (Ogdie et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Apremilast in Moderate to Severe Cases of Chronic Plaque Psoriasis: A Retrospective Study

Khan

Farooq

TARIQ

et al. 2023

Biol Clin Sci Res J

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The objective of this study was to assess the efficacy and safety of Apremilast in patients with moderate-to-severe plaque psoriasis. A retrospective study was conducted in the Dermatology Department of Bakhtawar Amin Trust Hospital Multan from September 2021 to September 2022. A total of 102 patients were included in the study after evaluation. Apremilast was administered in all the patients, and its clinical response was assessed by the extent of Psoriasis Area Severity Index (PASI) reduction 16 weeks after the start of treatment. Our secondary endpoints included examining the PASI; Dermatology Life Quality Index (DLQI); Physician Global Assessment (PGA); the adverse effects of treatment; survival rate; reasons for discontinuation of treatment, if any, and the rate of patients who managed to reach Psoriasis Area Severity Index reduction up to 50%, 75%, 90% and 100% after 16 weeks. 37 (72.5%) subjects achieved PASI reduction ≥75% or ≥50%, thus achieving the primary endpoint. The majority of the study sample had moderate psoriasis, with a mean baseline DLQI score of 11.2, PASI score of 11.0 and PGA score 2.6. After 16 weeks, 65% subjects had PGA score ≤1. PASI improved rapidly over 4 (4.8) (P<.001) to 16 weeks (4.3) (P<.001). DLQI at baseline was 11.2; after 16 weeks, it was 3.8 (P<.001). Regarding secondary endpoints, after 16 weeks, 35/37 (94.5%) subjects achieved ΔPASI≥50, 18/37 (48.6%) ΔPASI≥75, 8/37 (21.6%) achieved ΔPASI≥90 and 6/37(16.2%) achieved ΔPASI100. Treatment-related adverse effects occurred in 16/51 (31.3%) patients. In total, treatment was stopped in 6 (11.6%)subjects because of adverse effects; gastrointestinal disorders were the most common. Apremilast is an effective and safe drug for the treatment of patients with moderate-to-severe plaque psoriasis.

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Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Apremilast in Moderate to Severe Cases of Chronic Plaque Psoriasis: A Retrospective Study

Khan

Farooq

TARIQ

et al. 2023

Biol Clin Sci Res J

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“…According to research, participants with periodontitis have a larger correlation with stroke than people who have coronary artery disease [ 12 ]. It has been demonstrated that several autoimmune diseases such as Lupus Erythematosus [ 13 ], psoriasis [ 14 ], and Sjogren’s Syndrome [ 15 ], predispose the patients to periodontal diseases. Several studies exhibit that poor oral hygiene has been associated with predisposition to metabolic disorders, which in turn can pose a risk of stroke [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Link between Stroke Risk and Orodental Status—A Comprehensive Review

Shahi

Farhoudi

Dizaj

et al. 2022

JCM

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One of the primary causes of disability and mortality in the adult population worldwide is stroke. A person’s general health is significantly impacted by their oral and dental health. People who have poor oral health are more susceptible to conditions such as stroke. Stroke risk has long been linked to oral and dental conditions. The risk of stroke and its cost impact on the healthcare systems appear to be significantly reduced as a result of the decline in the incidence and prevalence of oral and dental illnesses. Hypothetically, better management of oral hygiene and dental health lead to reduced stroke risk. To the authors’ best knowledge, for the first time, the potential link between dental health and stroke were cross-examined. The most typical stroke symptoms, oral and dental illnesses linked to stroke, and the role of oral healthcare professionals in stroke prevention are revealed. The potential mediating processes and subsequent long-term cognitive and functional neurological outcomes are based on the available literature. It must be noted that periodontal diseases and tooth loss are two common oral health measures. Lack of knowledge on the effects of poor oral health on systemic health together with limited access to primary medical or dental care are considered to be partially responsible for the elevated risk of stroke. Concrete evidence confirming the associations between oral inflammatory conditions and stroke in large cohort prospective studies, stratifying association between oral disease severity and stroke risk and disease effects on stroke survival will be desirable. In terms of clinical pathology, a predictive model of stroke as a function of oral health status, and biomarkers of systemic inflammation could be useful for both cardiologists and dentists.

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“…Poor oral health, caused by inadequate dental hygiene and care, can aggravate the course of systemic diseases [ 1 , 2 , 3 ]. Similarly, systemic diseases or accompanying therapies may be reflected in the form of oral manifestations [ 4 , 5 ]. It is essential to emphasise the importance of dental prevention and care for all age groups, from children to the elderly [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%