Periodontal Disease in Different Stages of Chronic Kidney Disease

Abstract

-Periodontal disease is a chronic multifactorial disease the worldwide incidence of which is higher than the incidence of caries and represents one of the leading problems in dental medicine. It is manifested by the loss of the attachment apparatus of the tooth and leads to the loss of teeth. Numerous studies have shown the association of periodontal disease and various chronic systemic diseases such as diabetes mellitus and cardiovascular disease. It is believed that low-grade level of chronic inflammation and release of bacterial toxins and inflammatory mediators in the bloodstream aggravate a chronic systemic disease. The purpose of our research was to investigate the possible association of periodontal disease and chronic kidney disease via the inflammatory cytokines path. In this cross-sectional study, we surveyed a total of 80 subjects divided into two groups. First group included subjects with chronic renal disease stages III and IV, and the second group included patients with chronic renal disease stage V that were on hemodialysis. We compared periodontal status, as well as serum levels of different cytokines, interleukin 6, interleukin 17A and tumor necrosis factor α between the two groups. The results showed no significant between-group differences in periodontal status, but interleukin 6 levels were significantly higher in the hemodialysis group of patients and were also associated with a poorer periodontal status.

Correlação Entre Má Higiene Bucal E Complicações Sistêmicas Em Pacientes Internados Na Unidade De Terapia Inensiva: Uma Revisão Integrativa Da Literatura

“…A cárie pode ser definida como uma doença infecto-contagiosa caracterizada pela destruição dos tecidos dentais, através da desmineralização provocada por produtos bacterianos (PEREIRA; NEVES; TRINDADE, 2010). Já a doença periodontal pode ser definida como uma condição inflamatória crônica e multifatorial, caracterizada pelo sangramento gengival, hiperemia, edema e podem levar a perda de tecidos de suporte do dente (KOPIC et al, 2019).…”