Periodontal disease in a Rubinstein–Taybi syndrome patient: case report

Abstract

This case report underscores the importance of periodontal clinical diagnosis and the possibility of successful periodontal treatment in RTS patients.

Rubinstein-Taybi Syndrome: A Case Report

“…Freitas et al [19] reported the periodontal and immunological status of a 14-year-old female patient with RTS and possible association between syndrome and periodontal disease was reported in the paper. In this paper, heavy calculus and plaque deposition could be noted on all teeth.…”

Evaluation of the immune humoral response of Brazilian patients with Rubinstein-Taybi syndrome

“…Only one patient had serum IgG2 below the 3rd percentile. Freitas et al (13) described another Brazilian patient with RTS with periodontal diseases and recurrent respiratory infections and with high levels of serum total IgM. Xu et al (18) measured immunoglobulin levels in mice in which they had induced inactivation of the CBP or p300 alleles.…”

“…High serum levels of IgA antibodies, normal levels of IgG subclasses (IgG1, IgG2, IgG3, and IgG4) failed to respond to the Pneumovax vaccine (11). A Brazilian RTS patient with gum inflammation and bleeding was subjected to study of dental aspects (13). Additionally, this patient had recurrent respiratory infections in the first decade of life.…”

“…Additionally, this patient had recurrent respiratory infections in the first decade of life. Therefore, the authors conducted an immunological screening, which revealed normal levels of serum IgG and IgA antibodies, high IgM levels, normal anti-tetanus IgG levels, normal absolute values of total leukocytes in peripheral blood, and of lymphocytes, neutrophils, basophils, eosinophils and monocytes, as well as normal percentages of T CD4 + and T CD8 + cells (13). However, despite the high susceptibility of RTS patients to recurrent infections, there have been few reports about the evaluation of their immunocompetence (10,11).…”

Rubinstein–Taybi syndrome: A pediatric case report

“…[2] Male and female shows equal incidence. [2][3][4] RTS shows autosomal dominant mode of inheritance which involves mutations of genes encoding cAMPregulated enhancer binding protein (CREBBP) and E1A-binding protein p300 (EP300). Therefore, for the diagnosis of RTS, genetic tests are useful.…”