Periodontal Disease as a Possible Risk Factor for Alzheimer’s Disease

Abstract

Periodontal disease is a localized infectious disease caused by periodontal disease-related bacteria, such as Porphyromonas gingivalis. Recently, Periodontal disease is known to cause systemic spread of chronic inflammation and exacerbate lifestyle-related diseases such as ischemic heart disease, diabetes mellitus, and obesity, while the inflammatory response plays a large role in the development of neurodegenerative conditions such as Alzheimer's disease (AD).