Periodontal disease as a model to study chronic inflammation in aging

Bertolini, Martinna; Clark, Daniel

doi:10.1007/s11357-023-00835-0

Cited by 4 publications

(3 citation statements)

References 153 publications

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“…Treatment of this senescent phenotype might be therapeutically beneficial and could ameliorate periodontal disease. Bertolini et al [ 4 ] stated that periodontal disease is an age-related chronic inflammatory disease and proposed that periodontal disease might be an effective geroscience model to study mechanisms of age-related inflammatory dysregulation. Age-related changes in immune cells lead to less effective clearance of microbial pathogens and an increase in pro-inflammatory cytokine secretion.…”

Section: Discussionmentioning

confidence: 99%

“…Severe periodontitis is the sixth most prevalent disease and affects approximately 743 million people worldwide [ 3 ]. The prevalence of periodontal disease increases with age and thus, periodontal disease presents features of age-related inflammatory dysregulation [ 4 ]. Animal models have shown that treatment of this altered immuno-inflammatory physiology can also be therapeutically beneficial for periodontal disease [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis

Laky,

Arslan,

Zhu

et al. 2024

Nutrients

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Background: Periodontitis is an inflammatory condition initiated by oral bacteria and is associated with several systemic diseases. Quercetin is an anti-inflammatory and anti-bacterial poly-phenol present in various foods. The aim of this meta-analysis was the evaluation of the effects of quercetin administration in animal models of experimental periodontitis. Methods: A systematic search was performed in electronic databases using the following search terms: “periodontitis” or “periodontal disease” or “gingivitis” and “quercetin” or “cyanidanol” or “sophoretin” or “pentahydroxyflavone”. In vivo preclinical animal models of experimental periodontal disease with a measurement of alveolar bone loss were included in the analysis. The risk of bias of the included studies was assessed using the SYRCLE tool. Results: The systematic search yielded 335 results. Five studies were included, four of them qualified for a meta-analysis. The meta-analysis showed that quercetin administration decreased alveolar bone loss (τ2 = 0.31, 1.88 mm 95%CI: 1.09, 2.67) in experimental periodontal disease animal models. However, the risk of bias assessment indicated that four SYRCLE domains had a high risk of bias. Conclusions: Quercetin diminishes periodontal bone loss and prevents disease progression in animal models of experimental periodontal disease. Quercetin might facilitate periodontal tissue hemostasis by reducing senescent cells, decreasing oxidative stress via SIRT1-induced autophagy, limiting inflammation, and fostering an oral bacterial microenvironment of symbiotic microbiota associated with oral health. Future research will show whether and how the promising preclinical results can be translated into the clinical treatment of periodontal disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis

Laky,

Arslan,

Zhu

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Greater effect is seen with higher baseline HbA1c level ( 98 ), but decreases with increasing age ( 123 ), due to inflammaging or immunosenescence caused by diminishing immune defense efficiency in older ages ( 124 – 133 ).…”

Section: Effects Of Periodontal Treatmentmentioning

confidence: 99%

Current scientific evidence for why periodontitis should be included in diabetes management

Borgnakke

2024

Front. Clin. Diabetes Healthc.

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This Perspective provides a brief summary of the scientific evidence for the two-way links between periodontal diseases and hyperglycemia (diabetes mellitus [DM] and pre-DM). It delivers in a nutshell current scientific evidence for manifestations of hyperglycemia on periodontal health status and effects of periodontal diseases on blood glucose levels and in turn incidence, progression, and complications of diabetes. Of outmost importance is presentation of scientific evidence for the potential of routine periodontal treatment to lower blood glucose levels, providing a novel, economical tool in DM management. Non-surgical periodontal treatment (“deep cleaning”) can be provided by dental hygienists or dentists in general dental offices, although severe cases should be referred to specialists. Such therapy can decrease the costs of DM care and other health care costs for people with DM. The great importance of a healthy oral cavity free of infection and subsequent inflammation – especially periodontitis that if untreated will cause loosening and eventually loss of affected teeth – has largely gone unnoticed by the medical community as the health care curricula are largely void of content regarding the bi-directional links between oral health and systemic health, despite elevation of blood glucose levels being an integral part of the general systemic inflammation response. The importance of keeping disease-free, natural teeth for proper biting and chewing, smiling, self-esteem, and pain avoidance cannot be overestimated. Medical and dental professionals are strongly encouraged to collaborate in patient-centered care for their mutual patients with – or at risk for – hyperglycemia.

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Could the periodontal therapy improve the cardiologic patient health? A narrative review

Bertoldi,

Salvatori,

Pinti

et al. 2024

Current Problems in Cardiology

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Periodontal disease as a model to study chronic inflammation in aging

Cited by 4 publications

References 153 publications

Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis

Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis

Current scientific evidence for why periodontitis should be included in diabetes management

Could the periodontal therapy improve the cardiologic patient health? A narrative review

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