2021
DOI: 10.1590/s1677-5538.ibju.2020.0333
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Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies

Abstract: Background: Periodontal disease is reportedly associated with the risk of various systemic diseases, including pancreatic and lung cancers. However, its association with prostate cancer remains inconclusive. Herein, we explored the association of periodontal disease with the risk of prostate cancer through a meta-analysis. Materials and Methods: MEDLINE, Embase, Web of Sciences and Cochrane Library databases were searched for eligible publications up to April 2020. Mult… Show more

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Cited by 17 publications
(15 citation statements)
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“…This severe form of inflammation is called periodontitis [ 1 – 4 ]. Periodontal disease is prevalent in both developed and undeveloped countries, and it affects around 90% of the worldwide population [ 2 , 3 ]. Dental plaque is the main etiological factor for periodontal disease.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…This severe form of inflammation is called periodontitis [ 1 – 4 ]. Periodontal disease is prevalent in both developed and undeveloped countries, and it affects around 90% of the worldwide population [ 2 , 3 ]. Dental plaque is the main etiological factor for periodontal disease.…”
Section: Introductionmentioning
confidence: 99%
“…Periodontal bacteria, which is a constant potential source of infection, when it enters the bloodstream, causes activation of the immune cells. These activated cells produce cytokines (inflammatory biological signals) that have a highly adverse effect throughout the body system and have been linked to cardiovascular diseases, cerebrovascular diseases, peripheral arterial diseases, diabetes mellitus, and adverse pregnancy outcomes [ 2 , 4 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…Evidence indicates a link between periodontitis and systemic illness such as cardiovascular diseases, diabetes, adverse pregnancy outcomes and rheumatoid arthritis (RA) ( Cullinan et al., 2009 ). A correlation between periodontitis and cancer is also established; periodontitis is most consistently linked to increased risks of oral and esophageal cancers ( Fitzpatrick and Katz, 2010 ), but it is also associated with increased risks of other cancer types, such as prostate cancer ( Fitzpatrick and Katz, 2010 ; Lee et al., 2017b ; Guo et al, 2021 ; Wei et al, 2021 ). Among the numerous bacterial species that exist in the oral cavity, Porphyromonas gingivalis ( P. gingivalis ) is associated with severe forms of periodontitis ( Mysak et al., 2014 ).…”
Section: Introductionmentioning
confidence: 99%
“…92 Several studies confirmed that dislocation of oral pathogenic bacteria that are established to be involved in oral inflammatory diseases, such as periodontitis might be linked to PC. 93,94 In this case, increasing C-reactive protein (CRP) and pro-inflammatory cytokines, for example, (Interleukins) IL-1, IL-6, and (Tumor Necrosis Factor)…”
Section: Metagenomics and Its Effect On The Immune Systemmentioning
confidence: 99%
“…In recent studies, it was revealed that the host's microbiome, especially the gut microbiome can affect the cancer therapy efficiency through key mechanisms, such as immunomodulation, degradation, translocation, and metabolism 92 . Several studies confirmed that dislocation of oral pathogenic bacteria that are established to be involved in oral inflammatory diseases, such as periodontitis might be linked to PC 93,94 . In this case, increasing C‐reactive protein (CRP) and pro‐inflammatory cytokines, for example, (Interleukins) IL‐1, IL‐6, and (Tumor Necrosis Factor) TNF may cause prostate inflammation, followed by damaging prostate epithelium that ultimately results in PSA release 95,96 .…”
Section: Metagenomics and Its Effect On The Immune Systemmentioning
confidence: 99%