Periodontal disease and the metabolic syndrome

Lamster, Ira B.; Pagan, Michael

doi:10.1111/idj.12264

Cited by 133 publications

(137 citation statements)

References 67 publications

(108 reference statements)

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“…Several studies have reported an inter‐relationship between periodontal disease and MetS, although, to the best of the authors’ knowledge this is the first article to report data regarding MetS and peri‐implant diseases.…”

Section: Discussionmentioning

confidence: 91%

Prevalence of peri‐implant diseases among an Italian population of patients with metabolic syndrome: A cross‐sectional study

Papi

Murro

Bisogni

et al. 2019

Journal of Periodontology

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Background Over the years, only few authors have studied the association of systemic conditions with peri‐implantitis. The aim of this study is to detect frequency and severity of peri‐implant diseases among an Italian population of patients affected by metabolic syndrome (MetS). Methods In this cross‐sectional study, patients with at least one dental implant with >5 years of functional loading were screened to evaluate metabolic, periodontal, and peri‐implant status. MetS diagnosis was established in accordance with the National Cholesterol Education Program (NCEP) ATP III criteria, while case definitions of the 2017 World Workshop were adopted for peri‐implant diseases. For each implant, probing depths, mucosal redness, bleeding on probing, suppuration, plaque index, and marginal bone loss were recorded. Multinomial logistic regression analyzed the relationship between sex, diagnosis of MetS, presence of periodontitis, smoking, type of prosthesis, and location of implants and peri‐implant mucositis and peri‐implantitis. Results A total of 183 patients were enrolled: in MetS subjects, peri‐implantitis was detected in 36.9% (n = 31) of implants, and mucositis in 60.7% (n = 51), with an OR of 10.01(P = 0.005) for mucositis and OR 15.26 (P = 0.001) for peri‐implantitis, compared with subjects without MetS, where 26.3% of implants showed peri‐implantitis and 55.5% mucositis. No differences were found for smoking, implant location, sex, and type of prosthetic rehabilitation. Patients with periodontitis showed a higher association with peri‐implant mucositis (OR = 4.33) and peri‐implantitis (OR = 9.00). Conclusion Based on the results of this study, patients affected by MetS showed a greater prevalence of peri‐implant diseases, but further studies are needed to confirm the possibility of this new possible risk indicator.

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Section: Discussionmentioning

confidence: 91%

Prevalence of peri‐implant diseases among an Italian population of patients with metabolic syndrome: A cross‐sectional study

Papi

Murro

Bisogni

et al. 2019

Journal of Periodontology

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“…Periodontal treatment showed a beneicial efect on metabolic control of type 2 diabetic patients. Other various systemic diseases such as diabetes, cardiac disease, low birth weight, renal diseases, metabolic Role of Neutrophils in Disease Pathogenesissyndrome, obesity, Parkinson's disease, and Alzheimer's disease have been also proposed to be linked with periodontal disease on the basis of systemic inlammation [40,41,45].…”

Section: Periodontitismentioning

confidence: 99%

Neutrophil Role in Periodontal Disease

Rosales¹,

Uribe‐Querol²

2017

Role of Neutrophils in Disease Pathogenesis

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Oral tissues are constantly exposed to damage from the mechanical efort of eating and from the invasion of foreign microorganisms such as bacteria, fungi, and virus. In healthy oral tissues, there is a balance between symbiotic bacteria and cells from the innate immune system, mainly neutrophils. When this balance is broken, inlammation appears and more immune cells are recruited to the gingiva. Neutrophils form a barrier against dysbiotic bacteria. However, when neutrophils are insuicient, bacteria thrive causing periodontitis, a chronic inlammatory disease that destroys the tooth-supporting tissues or periodontium. Damage of periodontal tissues leads to tooth loss, and in severe cases, it can also afect systemic health by increasing a person's risk for atherosclerosis, rheumatoid arthritis, diabetes, and even cancer. The mechanisms neutrophil employ to keep a balance with bacteria in order to maintain healthy oral tissues is the focus of this chapter. We discuss how neutrophil antimicrobial functions keep bacteria at check and how some dysbiotic bacteria block neutrophils to promote an inlammatory state. Also, novel therapeutic approaches for periodontitis are discussed.

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“…The OxS is a phenomenon that occurs within the periodontal disease and has been linked with both onset of periodontal tissue destruction [23] and systemic inflammation [24]. Inflammatory periodontal disease resulting in tissue damage is mediated by ROS which are formed during the phagocytosis of periodontopathic bacteria by polymorphonuclear leukocytes.…”

Section: Periodontitis and Oxs: Nuclear And Oxidative Dna Damagementioning

confidence: 99%

Periodontal Disease and Nuclear and Oxidative DNA Damage

Zamora‐Pérez¹,

Zúñiga‐González²,

Gómez‐Meda³

et al. 2017

Insights Into Various Aspects of Oral Health

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Oral health is an important aspect of the overall health status of an individual. DNA damage has been associated with oral health and dental factors due to the increased of oxidative stress (OxS). DNA damage can produce a wide range of effects on human health. These effects could appear immediately, but others do not become evident much later. Chronic diseases have been study to understand their mechanisms, clinical implications, and the development of secondary disease such as cancer. Periodontitis is one of the most common oral diseases. It is an inflammatory chronic infectious disease, which is characterized by the loss of supporting tissues and tooth loss caused by periodontopathogens and long-term release of reactive oxygen species (ROS); thus, oxidative stress is increased during periodontitis. Oxidative stress can produce DNA damage, including the oxidation of nucleosides, which could cause DNA strand break. This oxidative damage leads the formation of micronuclei (MN) a marker of nuclear damage. Also, oxidative stress increased 8-hydroxy-2′-deoxyguanosine levels which are the most common stable product of oxidative DNA damage.

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Periodontal disease and the metabolic syndrome

Cited by 133 publications

References 67 publications

Prevalence of peri‐implant diseases among an Italian population of patients with metabolic syndrome: A cross‐sectional study

Prevalence of peri‐implant diseases among an Italian population of patients with metabolic syndrome: A cross‐sectional study

Neutrophil Role in Periodontal Disease

Periodontal Disease and Nuclear and Oxidative DNA Damage

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