Periodontal Disease and Other Nontraditional Risk Factors for CKD

Fisher, Mark T.; Taylor, George W.; Shelton, Brent J.; Jamerson, Kenneth; Rahman, Mahboob; Ojo, Akinlolu; Sehgal, Ashwini R.

doi:10.1053/j.ajkd.2007.09.018

Cited by 126 publications

(161 citation statements)

References 37 publications

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“…Glycated hemoglobin was used as an indicator of diabetes control with a cutoff of 7% (ADA, 2011). We constructed a variable for diabetes duration using a previously used cutoff point of 10 yrs (Fisher et al, 2008). History of cardiovascular disease (CVD) was constructed as a variable derived from the self-reported history of heart attack, stroke, heart failure, and hypertension (Kshirsagar et al, 2008).…”

Section: Materials and Methods Study Populationmentioning

confidence: 99%

Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease

Ioannidou¹,

Swede

Dongari-Bagtzoglou³

2011

J Dent Res

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Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis using the National Health and Nutrition Examination Survey 1988-1994 (NHANES III) dataset including 2303 individuals. We followed the American Academy of Periodontology (AAP)/Centers for Disease Control and Prevention (CDC) case definition for periodontitis. We used a cutoff point of 30% sites with (PD) ≥ 5 mm and (CAL) ≥ 4 mm to define generalized periodontitis cases. We estimated glomerular filtration rate based on cystatin C levels using the relevant equation. Urinary albumin-to-creatinine ratio was calculated in milligrams per gram with a cutoff point of 30 mg/g. CKD was defined based on eGFR < 60 mL/min/1.73m 2 and albuminuria ≥ 30 mg/g. Periodontitis was found in 427 (12.3%) individuals. Of individuals with periodontitis, 41.8% had serum CRP higher than 0.3 mg/dL compared with 27.1% of non-periodontitis and 53.1% of edentulous individuals (p = 0.001 for all comparisons). When the extent of periodontitis was used as one of the independent variables, the parsimonious model showed a strong independent association between extent of periodontitis and serum CRP levels (OR = 2.0, CI95% = 1.2-3.6).

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Section: Materials and Methods Study Populationmentioning

confidence: 99%

Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease

Ioannidou¹,

Swede

Dongari-Bagtzoglou³

2011

J Dent Res

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“…The interaction between periodontal and systemic diseases has been the focus of numerous studies, including chronic kidney disease (CKD) which is a major public health burden in the USA and many other countries (1,2). Increasing epidemiological evidence supports an association between periodontal disease and CKD (3)(4)(5)(6)(7). According to a clinical research of our team, 18.2 % of Chinese patients with the periodontal disease have proteinuria, hematuria, or reduced estimated glomerular fi ltration rate (eGFR), indicating the presence of kidney damage (8).…”

Section: Introductionmentioning

confidence: 99%

Periodontitis aggravates kidney damage in obese mice by MMP2 regulation

Chen¹,

Xuan²,

Zhang³

2018

BLL

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OBJECTIVE: To investigate the effect of periodontitis on the development of kidney damage in obese mice and its possible mechanism. METHODS: C57 BL/6J mice were fed high-fat (HF) or low-fat (LF) diet and then divided into four groups: obesity with periodontitis (HFP), obesity without periodontitis (HFC), normal mice with periodontitis (LFP) and normal mice without periodontitis (LFC). Serum indicators of renal function, namely serum total protein (TP), albumin (ALB), creatinine (Cr) and blood urea nitrogen (UREA) were measured. The histopathological examination of kidney tissues was performed. The expressions of transforming growth factor-β1 (TGF-β1), matrix metalloproteinase-2 (MMP2) and tissue inhibitors of metalloproteinases-1 (TIMP1) were detected by immunohistochemistry and real time RT-PCR. RESULTS: Obesity decreased TP and ALB, and increased serum Cr and UREA levels in normal and periodontitis mice groups, as well as induced glomerular and tubulointerstitial pathologic changes. Tubulointerstitial fi brosis was more severe in HFP group. In obese mice, periodontitis caused the downregulation of MMP2, and upregulation of TIMP1 and TGF-β1 at transcriptional and translational levels. CONCLUSIONS: In obese mice, periodontitis may aggravate pathological changes in the kidney. The possible mechanism might lie in downregulation of MMP2 and upregulation of MMP inhibitor, TIMP1, and Fig. 4, Ref. 16). Text in PDF www.elis.sk.

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“…19 In addition, periodontal disease has been identified as a risk factor for CKD in human patients, 20,21 and systematic review supports an association of periodontal disease and CKD. 22 A retrospective case-control study found dental disease to be a risk factor for CKD in dogs but not cats.…”

Section: Discussionmentioning

confidence: 98%

Risk factors for development of chronic kidney disease in cats

2018

Advances in Small Animal Medicine and Surgery

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Background: Identification of risk factors for development of chronic kidney disease (CKD) in cats may aid in its earlier detection.Hypothesis/objectives: Evaluation of clinical and questionnaire data will identify risk factors for development of azotemic CKD in cats.Animals: One hundred and forty-eight client-owned geriatric (>9 years) cats. Methods: Cats were recruited into the study and followed longitudinally for a variable time. Owners were asked to complete a questionnaire regarding their pet at enrollment. Additional data regarding dental disease were obtained when available by development of a dental categorization system. Variables were explored in univariable and multivariable Cox regression models.Results: In the final multivariable Cox regression model, annual/frequent vaccination (P value, .003; hazard ratio, 5.68; 95% confidence interval, 1.83-17.64), moderate dental disease (P value, .008; hazard ratio, 13.83; 95% confidence interval, 2.01-94.99), and severe dental disease (P value, .001; hazard ratio, 35.35; 95% confidence interval, 4.31-289.73) predicted development of azotemic CKD.Conclusion: Our study suggests independent associations between both vaccination frequency and severity of dental disease and development of CKD. Further studies to explore the pathophysiological mechanism of renal injury for these risk factors are warranted.

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Periodontal Disease and Other Nontraditional Risk Factors for CKD

Cited by 126 publications

References 37 publications

Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease

Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease

Periodontitis aggravates kidney damage in obese mice by MMP2 regulation

Risk factors for development of chronic kidney disease in cats

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