Periodontal Disease and its Association with Angiographically Verified Coronary Artery Disease

Vražić, Domagoj; Miovski, Zoran; Strozzi, Maja; Puhar, Ivan; Badovinac, Ana; Božić, Darko; Plančak, Darije

doi:10.15644/asc49/1/2

Cited by 5 publications

(8 citation statements)

References 31 publications

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“…Possible explanations include the fact that the study groups had mild, moderate and severe periodontitis patients ( Table 2 , Group 1 and Group 3). Vrazic, et al 33 (2015), and Zhu, et al 34 (2015) designed similar studies with similar patient groups. All studies showed significantly higher levels of the investigated parameters (IL-Ιβ, fibrinogen, CRP, etc.)…”

Section: Discussionmentioning

confidence: 98%

“…All studies showed significantly higher levels of the investigated parameters (IL-Ιβ, fibrinogen, CRP, etc.) 33 , 34 and significant associations between the presence of coronary heart disease or acute coronary syndrome with the clinical periodontal parameters 30 . However, all study groups had severe periodontitis 33 , 34 .…”

Section: Discussionmentioning

confidence: 99%

“… 33 , 34 and significant associations between the presence of coronary heart disease or acute coronary syndrome with the clinical periodontal parameters 30 . However, all study groups had severe periodontitis 33 , 34 . In this study, patients were grouped as having periodontitis or not.…”

Section: Discussionmentioning

confidence: 99%

“…The positive correlation between IL-10 and PD in the entire study group (N = 77) was surprising when the anti-inflammatory role of IL-10 in periodontal disease was considered. However, IL- 10 seems to be a protective factor in atherosclerosis against the effects of pathogens 33 . Also, it is known that increased serum IL-10 levels are associated with a positive prognosis in acute coronary syndrome patients 8 .…”

Section: Discussionmentioning

confidence: 99%

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Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area

Temelli

Savaş

et al. 2018

J. Appl. Oral Sci.

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ObjectivesOne of the plausible mechanisms in the relationship between periodontitis and coronary artery disease (CAD) is the systemic inflammatory burden comprised of circulating cytokines/mediators related to periodontitis. This study aims to test the hypothesis that periodontal inflamed surface area (PISA) is correlated with higher circulating levels of acute phase reactants (APR) and pro-inflammatory cytokines/mediators and lower anti-inflammatory cytokines/mediators in CAD patients.Material and MethodsPatients aged from 30 to 75 years who underwent coronary angiography with CAD suspicion were included. Clinical periodontal parameters (probing depth - PD, clinical attachment loss, and bleeding on probing - BOP) were previously recorded and participants were divided into four groups after coronary angiography: Group 1: CAD (+) with periodontitis (n=20); Group 2: CAD (+) without periodontitis (n=20); Group 3: CAD (-) with periodontitis (n=21); Group 4: CAD (-) without periodontitis (n = 16). Serum interleukin (IL) −1, −6, −10, tumor necrosis factor (TNF)-α, serum amyloid A (SAA), pentraxin (PTX) 3, and high-sensitivity C-reactive protein (hs-CRP) levels were measured with ELISA.ResultsGroups 1 and 3 showed periodontal parameter values higher than Groups 2 and 4 (p<0.0125). None of the investigated serum parameters were statistically significantly different between the study groups (p>0.0125). In CAD (-) groups (Groups 3 and 4), PISA has shown positive correlations with PTX3 and SAA (p<0.05). Age was found to predict CAD significantly according to the results of the multivariate regression analysis (Odds Ratio: 1.17; 95% Confidence Interval: 1.08-1.27; p<0.001).ConclusionsAlthough age was found to predict CAD significantly, the positive correlations between PISA and APR in CAD (-) groups deserve further attention, which might depend on the higher PISA values of periodontitis patients. In further studies conducted in a larger population, the stratification of age groups would provide us more accurate results.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area

Temelli

Savaş

et al. 2018

J. Appl. Oral Sci.

View full text Add to dashboard Cite

show abstract

“…This topic has emerged as one of the main area of research in Periodontics. Some studies have found links between chronic periodontal disease and coronary heart disease ( 8 ), stroke ( 9 ), acute myocardial infarct size ( 10 ), cerebrovascular disease ( 11 ), and development of atheromatous plaques ( 12 ). Despite numerous differences between chronic inflammatory diseases of periodontal and endodontic origins, both have important characteristics in common: they are chronic infections of the oral cavity; they share a common gram-negative anaerobic microbiota ( 13 ) and they are both accompanied by increased local levels of inflammatory markers which may extend to systemic levels ( 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Asymptomatic Apical Periodontitis and its Association with Coronary Artery Disease in a Brazilian Subpopulation

Oliveira¹,

Câmara²,

Aguiar³

2017

Acta Stomatol Croat

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ObjectiveThe aim of the present study was to determine the prevalence of asymptomatic apical periodontitis (AAP) and its association with coronary artery disease (CAD) in a Brazilian subpopulation, and to examine the correlation of AAP with gender, age and most frequently affected dental elements.MethodsThe data were collected from medical records of the patients (n = 1346) treated at the Specialization in Endodontics Clinic of the Federal University of Pernambuco in the period between 2003 and 2010. From each patient, the following variables were recorded: gender, age, endodontically compromised teeth, endodontic diseases diagnosed and the history of CAD. The data were analyzed using Pearson's chi-square test adopting a significance level of 5%.ResultsAAP was diagnosed in 574 patients (42.6%), corresponding to 641 teeth (40.1%). Both genders (p = 0.082), and all age groups (p = 0.190) were affected similarly. The upper incisors (52.8%, p <0.001) had a higher prevalence of AAP. The patients with AAP showed 1.45 times more chance of exhibiting CAD (p = 0.307).ConclusionsThe results pointed out that the prevalence of AAP in this population was high and similar to that observed in other countries. A positive association, but not statistically significant, between AAP and CAD was found.

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Comparison of intraoral biofilm reduction on silver-coated and silver ion-implanted stainless steel bracket material

et al. 2018

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PurposeThe objective of this in situ study was to quantify the intraoral biofilm reduction on bracket material as a result of different surface modifications using silver ions. In addition to galvanic silver coating and physical vapor deposition (PVD), the plasma immersion ion implantation and deposition (PIIID) procedure was investigated for the first time within an orthodontic application.Materials and methodsAn occlusal splint equipped with differently silver-modified test specimens based on stainless steel bracket material was prepared for a total of 12 periodontally healthy patients and was worn in the mouth for 48 h. The initially formed biofilm was fluorescently stained and a quantitative comparative analysis of biofilm volume, biofilm surface coverage and live/dead distribution of bacteria was performed by confocal laser scanning microscopy (CLSM).ResultsCompared to untreated stainless steel bracket material, the antibacterial effect of the PIIID silver-modified surface was just as significant with regard to reducing the biofilm volume and the surface coverage as the galvanically applied silver layer and the PVD silver coating. Regarding the live/dead distribution, however, the PIIID modification was the only surface that showed a significant increase in the proportion of dead cells compared to untreated bracket material and the galvanic coating.ConclusionsOrthodontic stainless steel with a silver-modified surface by PIIID procedure showed an effective reduction in the intraoral biofilm formation compared to untreated bracket material, in a similar manner to PVD and galvanic silver coatings applied to the surface. Additionally, the PIIID silver-modified surface has an increased bactericidal effect.

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Periodontal Disease and its Association with Angiographically Verified Coronary Artery Disease

Cited by 5 publications

References 31 publications

Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area

Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area

Prevalence of Asymptomatic Apical Periodontitis and its Association with Coronary Artery Disease in a Brazilian Subpopulation

Comparison of intraoral biofilm reduction on silver-coated and silver ion-implanted stainless steel bracket material

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