2011
DOI: 10.1016/j.metabol.2010.07.034
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Periodontal disease and hypertriglyceridemia in Japanese subjects: potential association with enhanced lipolysis

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Cited by 32 publications
(30 citation statements)
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“…Thus, observed high triglycerides in severe periodontitis subjects may also indicate enhanced lipolysis in such subjects. 27,28 Interestingly, elevated SAA in association with periodontitis has recently been reported, although this report did not indicate the source of SAA in such periodontitis patients. 29 …”
Section: Discussioncontrasting
confidence: 56%
See 1 more Smart Citation
“…Thus, observed high triglycerides in severe periodontitis subjects may also indicate enhanced lipolysis in such subjects. 27,28 Interestingly, elevated SAA in association with periodontitis has recently been reported, although this report did not indicate the source of SAA in such periodontitis patients. 29 …”
Section: Discussioncontrasting
confidence: 56%
“…25,26 A recent report indicated significant association between clinical severity of periodontitis and serum triglyceride level. 27 Furthermore, as mentioned above, obesity and/or overweight are associated with periodontitis. 12 Triglycerides are mainly synthesized in the liver from FFA following lipolysis.…”
Section: Discussionmentioning
confidence: 96%
“…Studies have shown positive association between dyslipidemia and periodontal disease [21,29,30]. In our previous animal study, feeding with a high-cholesterol diet increased serum lipid peroxidation and the number of TRAP-positive osteoclasts, with an increase in RANKL expression [14].…”
Section: Discussionmentioning
confidence: 99%
“…One of the major adipokines, tumor necrosis factor (TNF)-α, is known to induce lipolysis [10]. Therefore, we hypothesized that adipose-tissue inflammation-derived TNF-α may be associated with elevated levels of triglycerides, as following lipolysis, released free fatty acids are integrated into the liver and triglycerides are re-synthesized afterwards [11]. In fact, we already confirmed that cultured 3T3-L1 adipocytes exhibited higher lipolytic activity when co-cultured with macrophages in the presence of TNF-α- inducing molecule as bacterial endotoxin [11].…”
Section: Discussionmentioning
confidence: 99%