Periodontal Destruction Is Associated With Coronary Artery Disease and Periodontal Infection With Acute Coronary Syndrome

Gotsman, Israel; Lotan, Chaim; Soskolne, W. A.; Rassovsky, Simona; Pugatsch, Thea; Lapidus, Ludmila; Novikov, Yelena; Masrawa, Siham; Stabholz, Adam

doi:10.1902/jop.2007.060301

Cited by 70 publications

(61 citation statements)

References 41 publications

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“…In the present study, oral health was impaired and serum IgG levels against P. gingivalis (Pg IgG) increased in patients with a recent acute myocardial infarction, findings being in line with the results from recent studies [29][30][31]. Furthermore, Pg IgG levels were related to the oral health parameters, which are also in concordance with previous studies [15,32].…”

Section: Discussionsupporting

confidence: 93%

Porphyromonas gingivalis (Pg) a possible link between impaired oral health and acute myocardial infarction

Holmlund

Pussinen

et al. 2011

International Journal of Cardiology

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Section: Discussionsupporting

confidence: 93%

Porphyromonas gingivalis (Pg) a possible link between impaired oral health and acute myocardial infarction

Holmlund

Pussinen

et al. 2011

International Journal of Cardiology

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“…[16] Zhong et al .,[17] Gotsman et al . [18] and Zhang et al . [19] also identified Pg in 7.4%, 52%, 38.7%, 86%, 33% from atherosclerotic plaque samples, respectively.…”

Section: Discussionmentioning

confidence: 99%

Prevelance of periodontopathogenic bacteria in subgingival biofilm and atherosclerotic plaques of patients undergoing coronary revascularization surgery

Mahendra

Felix

et al. 2013

J Indian Soc Periodontol

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Aim:The objective of the present study was to detect the presence of specific periodontopathogenic bacteria in the coronary plaque of patients with coronary artery disease and to find out the significant association between the periodontal status and the presence of pathogenic bacteria in the coronary plaque.Materials and Methods:The study population consisted of 51 patients with chronic generalized periodontitis undergoing coronary artery bypass grafting. Periodontal parameters were recorded and deoxyribonucleic acid was extracted from the subgingival plaque and coronary atherosclerotic plaque samples of the same patients. Polymerase chain reaction was used to amplify the part of 16S ribosomal ribonucleic acid (rRNA) gene to detect the presence of Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Porphyromonas gingivali (Pg), Porphyromonas gingivalis (fimA) gene and Treponema denticola (Td).Results:Aa, Tf, Pg, Pg (fimA) gene and Td were detected in 0%, 31.4%, 45.1% 39.2% and 51% of atherosclerotic plaque samples, respectively. Tf was detected in 19.6%, Pg in 39.2%, Pg (fimA) gene in 33.3% and Td in 35.3% of both, subgingival plaque and atherosclerotic plaque samples. Periodontal parameters correlated with the presence of bacteria in coronary plaque. Aa could not be detected in coronary plaque samples.Conclusions:The study confirmed the detection of Red complex bacteria in coronary plaque samples and these bacteria correlated with the severity of periodontal destruction.

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“…Comparing the presence of periodontal bacteria in gingival pockets in patients with various levels of involvement of coronary arteries, Gotsman et al [27] detected a higher prevalence of Porphyromonas gingivalis in those with a greater number of vessels affected. In this direction, Stein et al [28] detected using hybridization techniques, the prevalence of Porphyromonas gingivalis in gingival pockets, in patients with acute myocardial infarction in comparison to their respective healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Inflamação sistêmica causada pela periodontite crônica em pacientes vítimas de ataque cardíaco isquêmico agudo

Oliveira

Vieira²,

Coelho³

et al. 2010

Rev Bras Cir Cardiovasc

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Inflamação sistêmica causada pela periodontite crônica em pacientes vítimas de ataque cardíaco isquêmico agudoSystemic inflammation caused by chronic periodontitis in acute ischemic heart attack patients Abstract Objective: Infectious and inflammatory processes mediated by bacteria in distant sites have been described as a risk factor for acute ischemic heart disease (AIHD).Methods: One hundred one patients with AIHD with and without chronic periodontitis (CP) were included in this study. Patients were admitted to the HC UNICAMP and stratified into three groups: in group 1, we selected patients with severe chronic periodontitis (31 men and 19 women, mean age 55.1 ± 11.29 years old); the group 2 with mild chronic periodontitis (40 men and 28 women, mean age 54.8 ± 10.37 years old) and group 3 represented by the toothless (43 men and 20 women, mean age 67.5 ± 8.55 years old). Blood samples were collected to measure the lipid profiles, hematological and blood glucose levels. In addition, biopsies of seventeen coronary arteries with atherosclerosis and an equal number of internal mammary arteries without atherosclerotic degeneration in group 1 were investigated. Statistical analysis by analysis of variance (ANOVA) and Scheffé test for multiple comparisons was performed.Results: Triglyceride and LDL levels were elevated in group 1 than in group 2. HDL were reduced by 20% in group 1 and remained reduced by 8% in toothless. Blood glucose was higher in group 1. DNA of periodontal bacteria was detected in 58.8% of the coronary arteries.Conclusions: Patients with (AIHD) and severe chronic periodontitis may have altered lipid profile, as well as microorganisms associated with CP can permeate into coronary vessels. Descriptors 52OLIVEIRA, FJ -Systemic inflammation caused by chronic periodontitis in acute ischemic heart attack patients Bras Cir Cardiovasc 2010; 25(1): 51-58 Rev

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Periodontal Destruction Is Associated With Coronary Artery Disease and Periodontal Infection With Acute Coronary Syndrome

Abstract: Periodontal destruction measures are significantly correlated with CAD severity, whereas periodontal infectious measures are significantly associated with clinical cardiac status.

Cited by 70 publications

References 41 publications

Porphyromonas gingivalis (Pg) a possible link between impaired oral health and acute myocardial infarction

Porphyromonas gingivalis (Pg) a possible link between impaired oral health and acute myocardial infarction

Prevelance of periodontopathogenic bacteria in subgingival biofilm and atherosclerotic plaques of patients undergoing coronary revascularization surgery

Inflamação sistêmica causada pela periodontite crônica em pacientes vítimas de ataque cardíaco isquêmico agudo

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