Periodontal Debridement: Still the Treatment of Choice

Drisko, Connie L.

doi:10.1016/j.jebdp.2014.02.007

Cited by 66 publications

(39 citation statements)

References 46 publications

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“…Scaling and root planing in conjunction with supragingival plaque control (PTC) is the current method to treat patients suffering from chronic periodontitis …”

Section: Discussionmentioning

confidence: 99%

“…Scaling and root planing in conjunction with supragingival plaque control (PTC) is the current method to treat patients suffering from chronic periodontitis. 19,20 In general, patients with periodontitis showed more VSC reduction after SRP than healthy controls or those with gingivi- However, of the eight included studies, none describes whether or not mouthwashes as an addition to SRP or PTC were used or recommended. This leaves room for discussion as the use of mouthwashes during the treatment of halitosis was stated to be beneficial.…”

Section: Discussionmentioning

confidence: 99%

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The effect of professional tooth cleaning or non‐surgical periodontal therapy on oral halitosis in patients with periodontal diseases. A systematic review

Deutscher

Derman

Barbe

et al. 2017

Int J Dental Hygiene

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“…Scaling and root planing in conjunction with supragingival plaque control (PTC) is the current method to treat patients suffering from chronic periodontitis …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of professional tooth cleaning or non‐surgical periodontal therapy on oral halitosis in patients with periodontal diseases. A systematic review

Deutscher

Derman

Barbe

et al. 2017

Int J Dental Hygiene

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“…In addition, Porphyromonas gingivalis even at very low colonization levels trigger changes to the amount and composition of oral commensal bacteria leading to inflammatory‐induced periodontal damage . Regarding the therapy, mechanical debridement to remove biofilm and calculus, thereby providing a supportive healthy oral environment, remains the gold standard of periodontal treatment . However, it is not possible to cure all periodontitis lesions through periodontal treatment and surgery, and the periodontal pockets that remain after treatment have to be carefully maintained, although there are some limitations to what can be done with standard treatment methods.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial function of the polyunsaturated fatty acid KetoC in an experimental model of periodontitis

Sulijaya

Yamada-Hara

Yokoji-Takeuchi

et al. 2019

Journal of Periodontology

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Background The bioactive metabolite KetoC, generated by intestinal bacteria, exerts various beneficial effects. Nevertheless, its function in the pathogenesis of periodontitis remains unclear. Here, we investigated the effect of KetoC in a mouse model of periodontitis and explored the underlying mechanism. Methods Thirty‐one 8‐week‐old male C57BL/6N mice were randomly divided into four groups (non‐ligation, non‐ligation + KetoC, ligation + Porphyromonas gingivalis, and ligation + P. gingivalis + KetoC) (n = 7/8 mice/group) and given a daily oral gavage of KetoC (15 mg/mL) or vehicle for 2 weeks. To induce periodontitis, a 5‐0 silk ligature was placed on the maxillary left second molar on day 7, and P. gingivalis W83 (109 colony‐forming unit [CFU]) was administered orally every 3 days. On day 14, all mice were euthanized. Alveolar bone destruction was determined from the level of the cemento‐enamel junction to the alveolar bone crest. Moreover, bone loss level was confirmed from gingival tissue sections stained with hematoxylin and eosin. The presence of P. gingivalis was quantified using real‐time polymerase chain reaction. In vitro, the bacteriostatic and bactericidal effects of KetoC were assessed by analyzing its suppressive activity on the proliferation of P. gingivalis and using a live/dead bacterial staining kit, respectively. A double‐bond‐deficient metabolite (KetoB) was then used to investigate the importance of double‐bond structure in the antimicrobial activity of KetoC on P. gingivalis. Results In vivo, KetoC attenuated alveolar bone destruction and suppressed P. gingivalis in the periodontitis group. In vitro, KetoC (but not KetoB) downregulated the proliferation and viability of P. gingivalis in a dose‐dependent manner. Conclusions KetoC reduced alveolar bone destruction in a periodontitis model via its antimicrobial function. Therefore, this bioactive metabolite may be valuable in clinical applications to support periodontal therapy.

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“…Periodontal debridement in combination with several adjunctive therapies including local use of antimicrobial agents, povidone‐iodine during debridement (Greenstein, ; Sahrmann et al ., ), chlorhexidine rinses (Southard et al ., ), subgingival gels, and systemic antibiotics have been used in the treatment of periodontitis with only moderate improvement in clinical outcomes. (Karlsson et al ., ; Schwarz et al ., ; Sgolastra et al ., ,b; Drisko, ). The limited efficacy of the current treatment options and the need for repeated treatments demand the need for development of novel methods to effectively treat periodontitis due to biofilms and prevent the associated tooth loss.…”

Section: Introductionmentioning

confidence: 99%

A bacterial‐biofilm‐induced oral osteolytic infection can be successfully treated by immuno‐targeting an extracellular nucleoid‐associated protein

Freire

Devaraj

Young

et al. 2016

Molecular Oral Microbiology

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Summary Periodontal disease exemplifies a chronic and recurrent infection with a necessary biofilm component. Mucosal inflammation is a hallmark response of the host seen in chronic diseases, such as colitis, gingivitis and periodontitis (and the related disorder peri-implantitis). We have taken advantage of our recently developed rat model of human peri-implantitis that recapitulates osteolysis, the requirement of biofilm formation and the perpetuation of the bona fide disease state, to test a new therapeutic modality with two novel components. First we utilized hyperimmune antiserum directed against the DNABII family of proteins, now known to be a critical component of the extracellular matrix of bacterial biofilms. Second we delivered the antiserum as cargo in biodegradable microspheres to the site of the biofilm infection. We demonstrated that delivery of a single dose of anti-DNABII in Poly(Lactic-co-glycolic acid) (PLGA) microspheres induced significant resolution of experimental peri-implantitis, including marked reduction of inflammation. These data support the continued development of a DNABII protein-targeted therapeutic for peri-implantitis and other chronic inflammatory pathologies of the oral cavity in animals and humans.

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Periodontal Debridement: Still the Treatment of Choice

Cited by 66 publications

References 46 publications

The effect of professional tooth cleaning or non‐surgical periodontal therapy on oral halitosis in patients with periodontal diseases. A systematic review

The effect of professional tooth cleaning or non‐surgical periodontal therapy on oral halitosis in patients with periodontal diseases. A systematic review

Antimicrobial function of the polyunsaturated fatty acid KetoC in an experimental model of periodontitis

A bacterial‐biofilm‐induced oral osteolytic infection can be successfully treated by immuno‐targeting an extracellular nucleoid‐associated protein

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