Periodicity in Disease

Non-specific mesenteric adenitis

“…The periodic syndrome (Reimann, 1957j British Medical Journal, 1957 is probably a number of disorders which are grouped for convenience under this heading. It can be defined as a disease of infants and children, sometimes affecting several members of a family, and at times hereditary, and which consists of acute paroxysmal episodes showing a certain periodicity.…”

Chemical Defence and Toxins of Plants

“…24 Sequence data indicated that HSSs from Boraginaceae, Asteraceae, and Orchidaceae have high homologies with deoxyhypusine synthase (DHS), an enzyme involved in the post-transcriptional activation of eukaryotic initiation factor 5A (elF5A), and have evolved several times independently from elF5A. 24,25 Thus in this case, the key enzyme involved in the synthesis of a secondary metabolite has evolved from an enzyme necessary for a basic biological function by change of function. After several steps, necine base is synthesized.…”

“…27 Figure 2 Synthetic pathway and activation process of pyrrolizidine alkaloid. [24][25][26] 4.08.1.2.1(ii) Nonprotein amino acids Nonprotein amino acids are amino acids other than the 20 amino acids incorporated in protein (Figure 3). More than 900 nonprotein amino acids have been reported from a wide variety of plants including Leguminosae, Liliaceae, Sapindaceae, Cycadaceae, Compositae, Rubiaceae, and Lecythidaceae.…”

“…23 Pyrrolizidine alkaloids are unique among alkaloids in that evolution of synthetic process, toxicology, ecological impacts on herbivorous insects, adaptation, detoxification, sequestration, and utilization as defense chemicals by insects are all well studied (Figure 2). 11,[24][25][26] The synthesis of necine base, the characteristic structure of PA, starts from the synthesis of homospermidine, catalyzed by homospermidine synthase (HSS), using primary metabolites spermidine and putrescine. 24 Sequence data indicated that HSSs from Boraginaceae, Asteraceae, and Orchidaceae have high homologies with deoxyhypusine synthase (DHS), an enzyme involved in the post-transcriptional activation of eukaryotic initiation factor 5A (elF5A), and have evolved several times independently from elF5A.…”