Periodic Mesoporous Organosilica Materials Incorporating Various Organic Functional Groups:  Synthesis, Structural Characterization, and Morphology

Wahab, M. A.; Imae, Ichiro; Kawakami, Yusuke; Ha, Chang‐Sik

doi:10.1021/cm0480059

Cited by 119 publications

(112 citation statements)

References 79 publications

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“…It can be seen that the two peaks at 43.45 and 50.64 disappeared, which is an indication that the epoxy ring was opened and the PLL was properly anchored. 41 The presence of PLL can be seen from the carbonyl (CdO) peak at 173.61 ppm. 42 The sequence of epoxysilane grafting followed by PLL attachment can also be verified by transmission FTIR.…”

Section: Articlementioning

confidence: 99%

Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery

et al. 2012

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Large pore mesoporous silica nanoparticles (LP-MSNs) functionalized with poly-l-lysine (PLL) were designed as a new carrier material for gene delivery applications. The synthesized LP-MSNs are 100–200 nm in diameter and are composed of cage-like pores organized in a cubic mesostructure. The size of the cavities is about 28 nm with an entrance size of 13.4 nm. Successful grafting of PLL onto the silica surface through covalent immobilization was confirmed by X-ray photoelectron spectroscopy, solid-state 13C magic-angle spinning nuclear magnetic resonance, Fourier transformed infrared, and thermogravimetric analysis. As a result of the particle modification with PLL, a significant increase of the nanoparticle binding capacity for oligo-DNAs was observed compared to the native unmodified silica particles. Consequently, PLL-functionalized nanoparticles exhibited a strong ability to deliver oligo DNA-Cy3 (a model for siRNA) to Hela cells. Furthermore, PLL-functionalized nanoparticles were proven to be superior as gene carriers compared to amino-functionalized nanoparticles and the native nanoparticles. The system was tested to deliver functional siRNA against minibrain-related kinase and polo-like kinase 1 in osteosarcoma cancer cells. Here, the functionalized particles demonstrated great potential for efficient gene transfer into cancer cells as a decrease of the cellular viability of the osteosarcoma cancer cells was induced. Moreover, the PLL-modified silica nanoparticles also exhibit a high biocompatibility, with low cytotoxicity observed up to 100 μg/mL.

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Section: Articlementioning

confidence: 99%

Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery

et al. 2012

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“…It is possible that the hollow fiber morphology is formed through the aforementioned packing of the self-assembled flexible rodlike organosilicate micelles. [34] With the distinctively prominent long organic bridging groups of our new organosilica precursor MI, the corresponding synthesized PMO materials can obtain excellent long fiber morphologies.…”

Section: Introductionmentioning

confidence: 99%

Periodic Mesoporous Organosilica Materials: Self‐Assembly of Carbamothioic Acid‐Bridged Organosilane Precursors

Gao

Feng

Zhou

et al. 2009

Chemistry A European J

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A new series of carbamothioic acid-containing periodic mesoporous organosilica (PMO) materials has been synthesized by a direct cocondensation method, in which an organosilica precursor N,S-bis[3-(triethoxysilyl)propyl]carbamothioic acid (MI) is treated with tetraethyl orthosilicate (TEOS), and the nonionic surfactant Pluronic 123 (P123) is used as a template under acidic conditions in the presence of inorganic additives. Moreover, the synthesis of the PMO material consisting of the MI precursor without TEOS has been realized. These novel PMO materials have large surface areas, well-ordered mesoporous structures, hollow fiberlike morphologies, and thick walls. They are also structurally well-ordered with a high organosilica precursor content, and the carbamothioic acid groups are thermally stable up to 250 degrees C. Furthermore, the organosilica materials exhibit hydrothermal stability in basic solution.

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“…The narrower pore mouths may be caused by enhanced carbon deposition at the entrance and/or by more narrow voids between blocked adjacent tube channels. This could be the results of presence of large mesopores and/or also the formation of some disordered like-pores in the framework [40,41]. These results clearly demonstrate the possibility of synthesizing uniform FMC with bimodal pore architectures.…”

Section: Preparation and Structural Features Of Mesoporous Sba15 Nanomentioning

confidence: 55%

Nano-Confined Synthesis of Fullerene Mesoporous Carbon (C60-FMC) with Bimodal Pores: XRD, TEM, Structural Properties, NMR, and Protein Immobilization

Wahab¹,

Darain²,

Karim³

et al. 2015

Int J Nanomater Nanotechnol Nanomed

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Nanoconfined synthesized crystalline fullerene mesoporous carbon (C 60 -FMC) with bimodal pore architectures of 4.95 nm and 10-15 nm pore sizes characterized by XRD, TEM, nitrogen adsorption/ desorption isotherm and solid-state NMR, and the material was used for protein immobilization. The solid-state 13 C NMR spectrum of C 60 -FMC along with XRD, BET and TEM confirms the formation of fullerene mesoporous carbon structure C 60 -FMC. The immobilization of albumin (from bovine serum, BSA) protein biomolecule in a buffer solution at pH 4.7 was used to determine the adsorption properties of the C 60 -FMC material and its structural changes investigated by FT-IR. We demonstrated that the C 60 -FMC with high surface area and pore volumes have excellent adsorption capacity towards BSA protein molecule. Protein adsorption experiments clearly showed that the C 60 -FMC with bimodal pore architectures (4.95 nm and 10-15 nm) are suitable material to be used for protein adsorption.and biomolecules or drugs adsorption on mesoporous carbons have been reported in the literatures [13][14][15][16][17][18][19][20]. It is also observed that mesoporous carbon materials exhibited better performance for these applications than that of counterpart silica material. Then, instead of using a conventional carbon source as mentioned above [1][2][3][4][12][13][14][15][16][17][18][19][20] it will be necessary to find a new carbon source to create a new mesoporous carbon solid framework that will improve the adsorption of biomolecules. As such, Fullerenes (C 60 ) as carbon source consists of nanoscopic building block with surface tailorable that can give unique functionalities to the mesoporous carbon framework [21][22][23]. Previously, fullerene C 60 has been partly used along with porous silica for extending their surface functionalities [24][25][26][27][28][29][30][31][32] but C 60 has not been reported to be used as sole carbon source for preparing fullerene mesoporous carbon that can be useful for protein immobilization.With this concept in mind, this paper, successfully demonstrate the use of fullerene C 60 as carbon source to prepare a new class of fullerene mesoporous carbon (C 60 -FMC) with bimodal pore architectures via pore filling method and its properties for protein immobilization. Experimental Section MaterialsTetraethylorthosilicate (TEOS), Pluronic surfactant P123 (EO20PPO70EO20), Fullerene C 60 , Trimethylbenzene (TMB) and Albumin from Bovine serum (BSA) from Sigma-Aldrich were used as received without further purification.

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Periodic Mesoporous Organosilica Materials Incorporating Various Organic Functional Groups: Synthesis, Structural Characterization, and Morphology

Cited by 119 publications

References 79 publications

Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery

Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery

Periodic Mesoporous Organosilica Materials: Self‐Assembly of Carbamothioic Acid‐Bridged Organosilane Precursors

Nano-Confined Synthesis of Fullerene Mesoporous Carbon (C60-FMC) with Bimodal Pores: XRD, TEM, Structural Properties, NMR, and Protein Immobilization

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