2011
DOI: 10.1186/1755-7682-4-23
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Periodic lateralized epileptiform discharges as manifestation of pneumococcal meningoencephalitis

Abstract: Periodic Lateralized Epileptiform Discharges (PLEDs) are usually seen in the context of destructive structural lesions of the cortex, more frequently in acute ischemic stroke and less common in tumours and meningoencephalitis, specially herpes simplex virus. Its origin and prognosis are uncertain but it is known that PLEDs are linked to epilectic seizures, including status epilepticus.We report on a 75-year old woman with pneumococcal meningoencephalitis who presented altered level of consciousness, acute foca… Show more

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Cited by 6 publications
(3 citation statements)
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“…PDs do not constitute a specific pattern of neurological disease ( 13 ). Associations between PDs and seizure have been studied in critically ill adult patients ( 1 , 4 ).…”
Section: Discussionmentioning
confidence: 99%
“…PDs do not constitute a specific pattern of neurological disease ( 13 ). Associations between PDs and seizure have been studied in critically ill adult patients ( 1 , 4 ).…”
Section: Discussionmentioning
confidence: 99%
“…LPDs are frequently associated with acute, structural brain lesion; very often with Ischemic stroke, viral encephalitis, including autoimmine encephalitis [10], tumors, intracerebral hemorrage (ICH) [11], Anoxic encephalopathy, Creutzfeldjacob disease CJD [12], Subarachnoid Hemorrage (SAH) [13], Multiple Sclerosis (MS), Posterior Reversible Encephalopathy Syndrome (PRES) ( Figure 3); they have been also reported in Migraine headache, Mitochondrial Encephalopathy with lactic acidosis and stroke like episodes, (MELAS).…”
Section: Etiologymentioning
confidence: 99%
“…Interestingly, the models mentioned above closely align with earlier hypotheses which concluded that inter-discharge intervals (in the pattern structure) can reflect a long refractory period. The discharges themselves reflect a massive depolarization of neurons, which are repeatedly excited by unknown stimuli (Gloor et al, 1968;Hernández-Fernández et al, 2011). Glutamate is a suitable candidate for the role of such a stimulus.…”
Section: Physiological Substrates Of Periodicitymentioning
confidence: 99%