Periodic Diseases

Reimann, HobartA.

doi:10.1016/s0140-6736(63)90581-6

Cited by 42 publications

(34 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most studies in female patients have failed to show a relationship between the episodes of neutropenia and the menstrual cycle, which is the only well-understood long-term human physiological cycle (Reimann, 1963). Although it is rare, it may prove to be of particular importance, for its study may provide insight into the normal control of granulopoiesis and into the genesis of biological rhythms.…”

mentioning

confidence: 99%

Familial Cyclical Neutropenia

1967

View full text Add to dashboard Cite

CYCLICAL neutropenia is a disorder of unknown cause characterized by episodes of neutropenia occurring at more or less regular intervals. Although it is rare, it may prove to be of particular importance, for its study may provide insight into the normal control of granulopoiesis and into the genesis of biological rhythms. The first case to be recognized was described by Leale ( I~I O ) , who noted an abnormal blood picture in a patient suffering from recurrent furunculosis. In I949 Reimann and deBerardinis collected 16 cases, published and unpublished, and described an additional case of their own. They suggested that cyclical neutropenia was a distinct entity, that only the more severely affected patients were recognized, and that specific search for the disease, especially amongst relatives of known sufferers, might disclose otherwise unsuspected cases. By 1963 Reimann was able to collect and review in his monograph Periodic Diseases a total of 42 cases. He emphasized their strikingly similar clinical and haematological features. The numbers of circulating neutrophils fell regularly, often at intervals of 20-21 days, and during the intervening periods were normal or moderately reduced. The cyclical changes in the peripheral blood followed cyclical changes in the bone marrow. Clinical manifestations nearly always appeared before the age of 10 years and tended to recur regularly thereafter. The commonest were fever, buccal ulceration and skin infections. The disease usually ran a benign course, although death due to infection occurred in four of his cases. Reimann found that splenectomy or administration of adrenal corticosteroids produced slight improvement in some cases, but no form of therapy ever resulted in a cure. More recently, Brodsky, Reimann and Dennis (1965) described one patient in whom clinical and haematological improvement followed therapy with testosterone.The aetiology of cyclical neutropenia remains unknown. Most studies in female patients have failed to show a relationship between the episodes of neutropenia and the menstrual cycle, which is the only well-understood long-term human physiological cycle (Reimann, 1963). A relationship between cyclical neutropenia and other periodic syndromes was suggested by Reimann and deBerardinis (1949). Occasional cases of the disease have been found in association with non-periodic diseases such as haemolytic anaemia (Doan, 1932), diabetes insipidus (Thompson, 1934), lymphosarcoma (Sandella, 1951 ;Natelson, 1953) and agammaglobulinaemia (Laski, Sass-Korstak and Hillman, 1954;Good and Varco, 1955). In a few cases the disease appears to have been genetically determined since studies of relatives of patients have revealed various forms of neutropenia. Thus Hahneman and Alt (1958), Gorlin and Chaudhry (1960) and Videbaek (1962) found cyclical neutropenia in a parent and child, and Good and Varco (1955) described two brothers, one suffering from cyclical neutropenia and the other from neutropenia which was apparently non-cyclical. In addition Vahlquist (1946),...

show abstract

mentioning

confidence: 99%

Familial Cyclical Neutropenia

1967

View full text Add to dashboard Cite

show abstract

“…No mention is made of three uncommon, repetitive entities characterized by abdominal pain as described in 1948 (Reimann, 1963). These are periodic peritonitis, periodic oedema (hereditary angio-oedema), and periodic pancreatosis (chronic relapsing pancreatitis).…”

Section: Three Periodic Diseases As Causes Of Recurrent Abdominal Paimentioning

confidence: 99%

Letter: Three periodic diseases as causes of recurrent abdominal pain in childhood.

Reimann¹

1976

Archives of Disease in Childhood

View full text Add to dashboard Cite

“…Werner Menzel, Jores' associate in chronomedicine, both in Hamburg, initiated curve-fitting, albeit without inferential statistical considerations, introduced a pump for clinical drug administration according to a preset schedule, and wrote a book on rhythms and shift-work, a source to the early literature [115], along with a book by Arne Sollberger [116]. These sources complement other books and the proceedings of other meetings [117-127]. …”

Section: Introductionmentioning

confidence: 99%

“…33. Today the importance of circaseptans in medicine is well apparent from inferentially analyzed morbidity and mortality statistics [185], complementing the time-macroscopic, most impressive data of Hobart Reimann [117] and Curt Richter [118]. Circaseptan patterns can be so interesting that one professor of medicine married his female patient, the better to study her more thoroughly [117].…”

Section: Introductionmentioning

confidence: 99%

Transdisciplinary unifying implications of circadian findings in the 1950s

Halberg

Cornélissen

Katinas

et al. 2003

J Circadian Rhythms

101

View full text Add to dashboard Cite

A few puzzles relating to a small fraction of my endeavors in the 1950s are summarized herein, with answers to a few questions of the Editor-in-Chief, to suggest that the rules of variability in time complement the rules of genetics as a biological variability in space. I advocate to replace truisms such as a relative constancy or homeostasis, that have served bioscience very well for very long. They were never intended, however, to lower a curtain of ignorance over everyday physiology. In raising these curtains, we unveil a range of dynamics, resolvable in the data collection and as-onegoes analysis by computers built into smaller and smaller devices, for a continued self-surveillance of the normal and for an individualized detection of the abnormal. The current medical art based on spotchecks interpreted by reference to a time-unqualified normal range can become a science of time series with tests relating to the individual in inferential statistical terms. This is already doable for the case of blood pressure, but eventually should become possible for many other variables interpreted today only based on the quicksand of clinical trials on groups. These ignore individual differences and hence the individual's needs. Chronomics (mapping time structures) with the major aim of quantifying normalcy by dynamic reference values for detecting earliest risk elevation, also yields the dividend of allowing molecular biology to focus on the normal as well as on the grossly abnormal.

show abstract

Periodic Diseases

Cited by 42 publications

References 3 publications

Familial Cyclical Neutropenia

Familial Cyclical Neutropenia

Letter: Three periodic diseases as causes of recurrent abdominal pain in childhood.

Transdisciplinary unifying implications of circadian findings in the 1950s

Contact Info

Product

Resources

About