Periodic breathing induced by hyperventilation.

Abstract

We thank the medical director and staff of the United Kingdom Transplant Service and the administrators and medical records officers of the 21 hospitals that cooperated in this study by providing details from patient case records.

The Impact of Altitude on Sleep-Disordered Breathing in Children Dwelling at High Altitude: A Crossover Study

“…[13][14][15][16][17][18]22,23 Prior physiologic studies have established that hyperventilation causes PB and CSA at high altitude. 34 We hypothesize that hyperventilation and increased arousal frequency also initiate a cascade of pathophysiologic consequences that precipitate increased frequency and severity of obstructive respiratory events in at-risk individuals. A model of OSA pathogenesis driven by four physiologic determinants including critical closing pressure, upper airway dilator recruitment threshold, loop gain, and arousal threshold has been proposed.…”