PERIOD3 polymorphism is associated with sleep quality recovery after a mild traumatic brain injury

Hong, Chien Tai; Wong, Chu‐Kwan; Ma, Hon-Ping; Wu, Dean; Huang, Yao-Hsien; Wu, Chung-Che; Lin, Chien-Min; Su, Yu-Kai; Liao, Kuo-Hsing; Ou, Ju Chi; Hu, Chaur‐Jong

doi:10.1016/j.jns.2015.09.376

Cited by 18 publications

(21 citation statements)

References 23 publications

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“…Other factors may include continued decreased levels of melatonin, changes in the circadian rhythm, and other psychosocial factors such as anxiety, depression, or change in activities and social interactions . Genetics also can play an important role in sleep regulation . Hong et al evaluated the presence of the PER3 gene polymorphism in individuals with concussion, and found those with the PER3 allele (morning preference) exhibited consolidated sleep and perceived improved daytime functioning 6‐weeks post‐concussion compared to the PER3 allele (evening preference) .…”

Section: Discussionmentioning

confidence: 99%

“…Genetics also can play an important role in sleep regulation . Hong et al evaluated the presence of the PER3 gene polymorphism in individuals with concussion, and found those with the PER3 allele (morning preference) exhibited consolidated sleep and perceived improved daytime functioning 6‐weeks post‐concussion compared to the PER3 allele (evening preference) . Further studies are needed to identify what factors or combination of factors contribute to the development and/or worsening of sleep disturbances following concussion.…”

Section: Discussionmentioning

confidence: 99%

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Sleep Disturbances in the Acute Stage of Concussion are Associated With Poorer Long‐Term Recovery: A Systematic Review

Ludwig

D’Silva

Vaduvathiriyan

et al. 2020

PM&R

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Objective: To examine the association between sleep during the acute stage of concussion and long-term outcomes. Literature Survey: Literature searches were performed 1 July 2018 to 1 August 2018 in Ovid MEDLINE, CINAHL, and Web of Science, along with hand searching for gray literature and cited references. Of the 610 search results, 359 unique references were reviewed after duplicates were removed. Methodology: Two reviewers independently reviewed and came to consensus on which titles/abstracts met inclusion/exclusion criteria (n = 23). The 23 full-text articles were assessed independently by the same two reviewers for eligibility. Consensus was achieved, leaving four articles for quality assessment and data extraction. One person extracted relevant data from each study using a standard data-extraction table. The data extraction table was reviewed by two reviewers and consensus was achieved for completeness and accuracy. Quality appraisal was conducted to assess the risk for potential bias and quality of included articles. Synthesis: Two of the articles included children younger than 16 years old and two included a wide age range. In general, poorer sleep was associated with poorer outcomes following concussion at reassessments across any age population. In addition, poorer sleep in the acute stage of concussion was associated with poorer long-term outcomes and recovery. Conclusions: The variability in sleep assessments used, symptoms assessed, length of time to reassessments, and comparator group included made data synthesis challenging. The use of standard valid and reliable sleep assessments is recommended. Future studies may consider if addressing sleep disturbances early following concussion will improve longer-term outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sleep Disturbances in the Acute Stage of Concussion are Associated With Poorer Long‐Term Recovery: A Systematic Review

Ludwig

D’Silva

Vaduvathiriyan

et al. 2020

PM&R

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“…[54][55] A further 21 studies reported on varied miscellaneous SNPs that did not fall into any of the previous groupings. [57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][80][81][82][83] Study design varied. Fifty-four publications described prospective cohort studies 16,17,[19][20][21][22][23][24][26][27][28][29][30][31]34,35,37,38,[40][41][42][43][44][46][47][48][49][50]…”

Section: Patient and Study Demographicsmentioning

confidence: 99%

“…Fifty-four publications described prospective cohort studies 16,17,[19][20][21][22][23][24][26][27][28][29][30][31]34,35,37,38,[40][41][42][43][44][46][47][48][49][50][51][52][53]55,[57][58][59][60][61][62][63][64][66][67][68][69]71,[73][74][75][76][77][78][79][80]…”

Section: Patient and Study Demographicsmentioning

confidence: 99%

“…Ten studies documented the relationship between various SNPs and nonglobal patient outcomes (i.e., neuropsychiatric, behavioral, and other). 57,60,66,67,69,[71][72][73]82,83 The targets for these polymorphisms included: ACE, 57 various oxytocin SNPs, 66 PERIOD3, 67 ATP binding cassette, 60 nitric oxide synthase-3 (NOS3), 69 alpha synuclein (SNCA), 71 kidney and brain expressed protein (KIBRA), 72 BMX, 73 methyenetetrahydrofolate reductase (MTHFR), 82 and adenosine A1 receptor. 83 Full details can be found in Supplementary Appendix 9.…”

Section: Patient-oriented Outcomes In Tbimentioning

confidence: 99%

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Genetic Influences on Patient-Oriented Outcomes in Traumatic Brain Injury: A Living Systematic Review of Non-Apolipoprotein E Single-Nucleotide Polymorphisms

Zeiler

McFadyen

Newcombe

et al. 2021

Journal of Neurotrauma

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There is a growing literature on the impact of genetic variation on outcome in traumatic brain injury (TBI). Whereas a substantial proportion of these publications have focused on the apolipoprotein E (APOE) gene, several have explored the influence of other polymorphisms. We undertook a systematic review of the impact of single-nucleotide polymorphisms (SNPs) in non-apolipoprotein E (non-APOE) genes associated with patient outcomes in adult TBI). We searched EMBASE, MEDLINE, CINAHL, and gray literature from inception to the beginning of August 2017 for studies of genetic variance in relation to patient outcomes in adult TBI. Sixty-eight articles were deemed eligible for inclusion into the systematic review. The SNPs described were in the following categories: neurotransmitter (NT) in 23, cytokine in nine, brain-derived neurotrophic factor (BDNF) in 12, mitochondrial genes in three, and miscellaneous SNPs in 21. All studies were based on small patient cohorts and suffered from potential bias. A range of SNPs associated with genes coding for monoamine NTs, BDNF, cytokines, and mitochondrial proteins have been reported to be associated with variation in global, neuropsychiatric, and behavioral outcomes. An analysis of the tissue, cellular, and subcellular location of the genes that harbored the SNPs studied showed that they could be clustered into blood-brain barrier associated, neuroprotective/regulatory, and neuropsychiatric/degenerative groups. Several small studies report that various NT, cytokine, and BDNF-related SNPs are associated with variations in global outcome at 6-12 months post-TBI. The association of these SNPs with neuropsychiatric and behavioral outcomes is less clear. A definitive assessment of role and effect size of genetic variation in these genes on outcome remains uncertain, but could be clarified by an adequately powered genome-wide association study with appropriate recording of outcomes.

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Sleep After Traumatic Brain Injury

Mollayeva

2022

Sleep and Neuropsychiatric Disorders

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PERIOD3 polymorphism is associated with sleep quality recovery after a mild traumatic brain injury

Cited by 18 publications

References 23 publications

Sleep Disturbances in the Acute Stage of Concussion are Associated With Poorer Long‐Term Recovery: A Systematic Review

Sleep Disturbances in the Acute Stage of Concussion are Associated With Poorer Long‐Term Recovery: A Systematic Review

Genetic Influences on Patient-Oriented Outcomes in Traumatic Brain Injury: A Living Systematic Review of Non-Apolipoprotein E Single-Nucleotide Polymorphisms

Sleep After Traumatic Brain Injury

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