Periocular Skin Cancer in Solid Organ Transplant Recipients

Perry, Julian D.; Polito, Sara C.; Chundury, Rao V.; Singh, Arun D.; Fritz, Michael A.; Vidimos, Allison; Gastman, Brian; Koyfman, Shlomo A.

doi:10.1016/j.ophtha.2015.09.030

Cited by 10 publications

(6 citation statements)

References 25 publications

(33 reference statements)

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“…As postinflammatory hyperpigmentation cannot be differentiated from a persistent lesion, a regular follow-up with a timely histological analysis should be done in these patients. Immunosuppressed patients are not only known to have an up to 90 times increased risk of developing skin cancer [41, 42], but also to follow a more aggressive course [43]. In our study, however, the status of immunosuppression did not differ significantly between the patients who developed and who did not develop a relapse (11.4 vs. 14.2%, respectively, p > 0.05).…”

Section: Discussioncontrasting

confidence: 64%

Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study

et al. 2019

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Background: Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge. Objective: To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors. Methods: Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) with associated in situ lesions, cutaneous melanoma, lentigo maligna (LM), cutaneous lymphoma and Kaposi’s sarcoma were included in the analysis. Results: We found 159 periocular lesions in 145 patients. Overall recurrence was highest for actinic keratosis and Bowen’s disease (27%), melanoma (17%) and LM (15%), whereas SCC and BCC showed recurrence in 11 and 10%, respectively. 45% of all recurrences occurred within 12 months after treatment, with a median time to recurrence of 13 months (range 3–73). Conclusion: RT, which provides a good therapeutic response with minimal adverse events, is a therapy option for periocular cutaneous malignancies.

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Section: Discussioncontrasting

confidence: 64%

Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study

et al. 2019

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“…Incidence increases with the duration of immunosuppression (72). Risk factors include ultraviolet (UV) light exposure, human papillomavirus (HPV) infection and prior skin cancers (74)(75)(76). Individual drugs increase its risk by different mechanisms.…”

Section: Squamous Cell Carcinoma (Scc) Of the Conjunctiva And Eyelidsmentioning

confidence: 99%

“…Treatment includes surgical excision with clear margins whenever possible. Moh's micrographic technique has been used in some cases (76). Invasive tumors require extensive surgical procedures including use of skin flaps, parotidectomy, cheek lift and even exenteration (76,79).…”

Section: Squamous Cell Carcinoma (Scc) Of the Conjunctiva And Eyelidsmentioning

confidence: 99%

“For your eyes only”: ophthalmic complications following lung transplantation

et al. 2018

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Ophthalmic complications in the lung transplant population are a little-known entity. It includes a spectrum of diseases ranging from infections such as cytomegalovirus (CMV) retinitis, herpetic keratitis, Pseudallescheria boydii to non-infectious complications such as posterior subcapsular cataracts (PSCs), cyclosporine retinopathy, and post-transplant lymphoproliferative disorder (PTLD). These diseases can be attributed to high levels of immunosuppression, advanced age, and drug-specific side effects. Underlying comorbidities such as diabetes mellitus may also play a role in the pathogenesis. Patients can present with varied symptoms such as blurry vision, floaters or eye pain. Prompt diagnosis often requires a high index of suspicion. With increasing numbers of transplants being performed worldwide, it is imperative for the pulmonologist and transplant physician to recognize these often subtle symptoms. Any visual symptom should trigger an ophthalmological evaluation in order to manage these complications; some of which pose the risk of systemic dissemination and significant morbidity. The following article provides an indepth review of the common presenting symptoms, treatments and recent advances related to common ophthalmic complications following lung transplantation. While this article focuses on the lung transplant sub-population, the authors would like to point out that some of these complications are shared by other solid-organ transplants as well, by virtue of their shared immunosuppressive therapies.

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“…Malignant tumors require aggressive treatment and surveillance because these malignancies may cause globe exposure, nerve damage, vision loss, or even death and have important cosmetic complications ( Perry et al, 2016 ). BCC is the most common form of skin cancer in Caucasians over the age of 50 years with a very high percentage of periocular malignancies (90%) distributed as follows: lower eyelid (43%), medial canthus (26%), upper eyelid (12%), and lateral canthus (8%; Fig.…”

Section: Malignant Tumorsmentioning

confidence: 99%