Periocular Injection of Microspheres Containing PKC412 Inhibits Choroidal Neovascularization in a Porcine Model

Saishin, Yoshitsugu; Silva, Raquel Lima; Saishin, Yumiko; Callahan, Kevin P.; Schoch, Christian; Ahlheim, M.; Li, Hong; Kane, Frances; Brazzell, Romulus K.; Bodmer, David; Campochiaro, Peter A.

doi:10.1167/iovs.03-0600

Cited by 84 publications

(42 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PKC412 (Novartis) has been shown to be effective in animal models via both oral and periocular use. 46 This has also been shown to be effective in diabetic macular oedema. Ruboxistaurin mesylate, a PKC b inhibitor, has now completed phase-III trials for diabetic macular oedema, and may be a potential treatment option in AMD.…”

Section: Blocking Signal Transductionmentioning

confidence: 98%

Looking beyond Lucentis on the management of macular degeneration

Fletcher

Chong

2008

Eye

View full text Add to dashboard Cite

Purpose Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. In the past decade, AMD research has improved our understanding of the pathogenesis of the condition. There is no doubt that anti-VEGF therapies will play a major role in the reduction of blindness, but it needs close monitoring and frequent treatments. In this review we summarise the key pathophysiology of the condition and some of the new treatment strategies under development. Methods Literature review. Results Oxidative stress, inflammation, hypoxia, and angiogenesis are key pathophysiological processes in AMD, this diversity has provided a variety of possible areas amenable to modification to enhance the treatment options for AMD.

show abstract

Section: Blocking Signal Transductionmentioning

confidence: 98%

Looking beyond Lucentis on the management of macular degeneration

Fletcher

Chong

2008

Eye

View full text Add to dashboard Cite

show abstract

“…68 Ruboksistaurin ile yapılan in vivo ve in vitro çalışmalarda, molekülün ERK1/2'yi baskılayarak Kübra KÜÇÜKİBA ve ark.…”

Section: Tirozin Kinaz İnhibitörleriunclassified

Corneal Neovascularization and Treatment: Review

Küçükiba¹,

Yıldırım²

2017

Turkiye Klinikleri J Ophthalmol

View full text Add to dashboard Cite

“…Intravitreal injections can potentially impair vision due to clouding. However, microspheres larger than 2 μm tend to settle out owing to gravity, whereas nanoparticulates diffuse quickly and localize within ocular tissues [82]. Table 5 Phagocytosis of the microspheres, with or without gelatin precoating, was carried out at 37˚C and 4˚C.…”

Section: Nanoparticulate Transscleral Drug Delivery Systemsmentioning

confidence: 99%

Nanoparticulate Transscleral Ocular Drug Delivery

Shah¹,

Shah²,

Groshev³

et al. 2014

J Biomol Res Ther

View full text Add to dashboard Cite

Ocular drug delivery is one of the most challenging areas of drug delivery due to the unique mostly avascular nature of the major eye structures and presence of two blood barriers. Effectiveness of a more conventional systemic delivery falls short due to low drug levels in the eye tissue. Periocular approaches require penetration of fibrous sclera and present their own limitations. Utilization of nanotechnology presents new avenue of drug system development with potential to penetrate protective barriers and sustain ample tissue saturation. More specifically, transscleral delivery permits a range of applications in targeted delivery, gene, stem cell, protein and peptides, oligonucleotide, and ribozyme therapies. The exciting range of current applications is expounded in this review.

show abstract

Periocular Injection of Microspheres Containing PKC412 Inhibits Choroidal Neovascularization in a Porcine Model

Abstract: Sustained local delivery of PKC412 provides a promising approach for treatment of CNV.

Cited by 84 publications

References 13 publications

Looking beyond Lucentis on the management of macular degeneration

Looking beyond Lucentis on the management of macular degeneration

Corneal Neovascularization and Treatment: Review

Nanoparticulate Transscleral Ocular Drug Delivery

Contact Info

Product

Resources

About