Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: Experience in a Mexican institution

Yamamoto-Furusho, Jesús K.; Takahashi-Monroy, Takeshi; Vergara-Fernández, Omar; Reyes, Edgardo; Uscanga, Luis

doi:10.3748/wjg.v12.i21.3406

Cited by 6 publications

(8 citation statements)

References 29 publications

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“…Although the observed prevalence fits within the previously reported range, it was quite low compared to that observed in Western countries [10,17,21] and is closer to the results of studies initiated in Asian countries [20,22]. Differences in clinical patterns of UC between races or ethnic groups may help us to understand the etiology or pathogenesis of the disease.…”

Section: Discussionsupporting

confidence: 85%

“…Further studies are necessary to clarify the ethnic In addition to the diagnostic value of pANCA, many studies have evaluated the relationship between pANCA and clinical course or disease activity of UC, but these are still under debate. Several reports have demonstrated a significant relationship between serum titer pANCA and the clinical course or severity of UC [3,6,18,21]. In addition, some investigators have identified a relationship between psychological factors and pANCA status [27,28], while others found no correlation [3,10,25].…”

Section: Discussionmentioning

confidence: 99%

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The Prevalence and Clinical Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Korean Patients with Ulcerative Colitis

et al. 2009

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Perinuclear anti-neutrophil cytoplasmic antibody (pANCA) is a serological marker associated with various immune-mediated diseases whose clinical significance and possible diagnostic roles in ulcerative colitis (UC) are still unclear. We aimed to evaluate the prevalence of pANCA expression and its association with clinical findings and disease course in Korean patients with UC. This study included 484 patients with UC who were diagnosed and treated between 1990 and 2006 at Severance Hospital, Yonsei University, Seoul, Korea, and were followed for at least 1 year. Clinical findings at diagnosis, disease extent, treatment modalities used, and cumulative relapse rates were analyzed and compared to pANCA expression. Of the 484 patients, 405 (83.7%) were evaluated for pANCA and were eligible for analysis. The overall pANCA prevalence was 22.1%, with a female preponderance (male, 21.5%; female, 31.6%; P < 0.05). Proctitis was more common in pANCA-negative patients (pANCA-negative, 37.6%; pANCA-positive, 25.2%, P < 0.05). UC activity index and cumulative relapse rates were higher in pANCA-positive patients. However, there were no significant differences in the cumulative probability of steroid and immunosuppressant use and operation rate between the two groups. The prevalence of pANCA expression in Korean patients with UC was relatively low compared to that in Western countries. Although UC patients with pANCA expression had more severe clinical findings at diagnosis and higher cumulative relapse rates in our study, further prospective studies are warranted to clarify whether pANCA positivity influences the initial clinical presentation or disease aggressiveness.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

The Prevalence and Clinical Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Korean Patients with Ulcerative Colitis

et al. 2009

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“…The prevalence of pANCA in Japanese,148 Korean,149 Thai,150 and Romanian151 patients with UC is lower compared with Caucasians, but comparable to Caucasian data in Mexico,152 Estonia,153 and a different Korean cohort 142. pANCA was found more frequently in UC patients with more extensive disease in China147 and Korea,149 with relapse rates higher when pANCA was present in the Korean cohort 149…”

Section: Ethnic Differences In Serological Antibodiessupporting

confidence: 52%

Serological Antibodies in Inflammatory Bowel Disease: A Systematic Review

Prideaux

Cruz

et al. 2012

Inflammatory Bowel Diseases

171

145

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The diagnosis of inflammatory bowel disease (IBD) is traditionally based on a combination of clinical, endoscopic, histological, and radiological criteria. However, further testing is needed in cases of diagnostic uncertainty and in predicting disease course. This systematic review focuses on the potential for 10 serological antibodies to fill these roles: pANCA, ASCA, anti-OmpC, anti-CBir1, anti-I2, ALCA, ACCA, AMCA, anti-L, and anti-C. We discuss their prevalence in IBD and health; their role in disease diagnosis and risk stratification; their stability over time; their presence in unaffected relatives; their association with genetic variants; and differences across ethnic groups. Serological antibodies have some role in primary diagnosis and in differentiating between Crohn's disease and ulcerative colitis. In indeterminate colitis, preoperative measurement of serological antibodies can help to predict the likelihood of complications among patients undergoing pouch surgery. The combined presence and magnitude of a large panel of antibodies appear to be of value in predicting disease progression. There is currently insufficient evidence to recommend the use of antibody testing to predict responses to treatment or surgery in patients with IBD.

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“…This association has been found between ANAs and SLE, 23 and between p-ANCA and UC. 7 We studied the association of ANAs with the activity of UC measured by the Mayo score and no positive correlation was found. In order to establish if ANAs are associated with UC activity we also compared ANAs with CRP levels, which has been demonstrated to be a reliable serological marker of disease activity, 24 -28 and no association was found.…”

Section: Discussionmentioning

confidence: 97%

“…6 The prevalence of p-ANCA in Mexican UC patients is 51% and seems to be a marker in those with severe activity (P Ͻ 0.0001; odds ratio [OR] ϭ 9; 95% confidence interval [CI] ϭ 3.2-24.7). 7 There is evidence showing that the presence of p-ANCA is also associated with a more aggressive clinical course. 8 On the other hand, Aitola et al 9 reported that p-ANCA titers decrease after proctocolectomy, suggesting that a reduction of the inflammatory process may modify the immunological alteration related to UC.…”

mentioning

confidence: 99%

Antinuclear antibodies: A marker associated with steroid dependence in patients with ulcerative colitis

Barahona-Garrido¹,

Camacho-Escobedo²,

García-Martínez³

et al. 2009

Inflammatory Bowel Diseases

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Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: Experience in a Mexican institution

Abstract: The prevalence of p-ANCA was similar to that reported in other countries. Their presence was associated to UC severity, but offered no more information than the obtained by clinical methods.

Cited by 6 publications

References 29 publications

The Prevalence and Clinical Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Korean Patients with Ulcerative Colitis

The Prevalence and Clinical Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Korean Patients with Ulcerative Colitis

Serological Antibodies in Inflammatory Bowel Disease: A Systematic Review

Antinuclear antibodies: A marker associated with steroid dependence in patients with ulcerative colitis

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