Perinodular hydropic degeneration in uterine leiomyoma causing rapid enlargement and mimicking a myxoid smooth muscle tumor: Case report of a diagnostic challenge

Khader, Ali; Nsour, Esra; Abdallat, A

doi:10.1016/j.crwh.2019.e00150

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…At the same time, with complete resection of all tumors being another possible treatment strategy, resection of the fluid-containing tumor in the right upper lobe arguably could have been performed instead of the left lung biopsy in the current The rapid enlargement of uterine leiomyoma may result from infarction or cystic change in the leiomyoma. In addition, peri-nodular hydropic degeneration has occasionally been observed as a pathological feature [9]. However, only monolocular cystic change in the tumor was observed in the present case.…”

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confidence: 46%

Rapid enlargement of pulmonary benign metastasizing leiomyoma with fluid-containing cystic change: a case report

et al. 2022

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Background Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease that can occur in women with a history of uterine leiomyoma. Despite its benign histological features, like a malignancy, leiomyomas can on rare occasion spread to the lung. Typically, PBML presents with asymptomatic multiple solid lung nodules with slow tumor progression, following hysterectomy. Here, we present an atypical case with rapid enlargement of PBML with fluid-containing cystic change. Case presentation We experienced a case of a 49-year-old woman with bilateral lung nodules following hysterectomy. Two nodules in the right lung had cystic change with fluid in the tumors. Hormone therapy was initiated after surgical biopsy of the left lung confirmed a diagnosis of PBML. However, the cystic component of right upper lobe lesion enlarged rapidly over the following 7 months, and, considering the risk of malignant transformation or tumor rupture, right upper lobectomy was performed. Pathologically, the fluid-containing tumor was diagnosed as PBML. Conclusion Given the risk of rapid progression, we should carefully consider the surgical indications of fluid-containing PBML.

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