Perineuronal nets are phagocytosed by MMP‐9 expressing microglia and astrocytes in the SOD1G93A ALS mouse model
Sang Won Cheung,
Ekta Bhavnani,
David G. Simmons
et al.
Abstract:AimsPerineuronal nets (PNNs) are an extracellular matrix structure that encases excitable neurons. PNNs play a role in neuroprotection against oxidative stress. Oxidative stress within motor neurons can trigger neuronal death, which has been implicated in amyotrophic lateral sclerosis (ALS). We investigated the spatio‐temporal timeline of PNN breakdown and the contributing cellular factors in the SOD1G93A strain, a fast‐onset ALS mouse model.MethodsThis was conducted at the presymptomatic (P30), onset (P70), m… Show more
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