Perineurioma of the Tongue: A Case Report and Review of the Literature

Lobulated nodule arising on the tongue in a young patient

“…Intraoral perineuriomas are rare, and there have been only 19 reported cases of the intraneural type in this location (Ko et al, 2020; Schadel et al, 2019). Clinically, most of them are painless, slow‐growing submucosal nodules (da Cruz Perez et al, 2006), and the most frequently involved subsites were the tongue and the mandible (Schadel et al, 2019).…”

“…Intraoral perineuriomas are rare, and there have been only 19 reported cases of the intraneural type in this location (Ko et al, 2020; Schadel et al, 2019). Clinically, most of them are painless, slow‐growing submucosal nodules (da Cruz Perez et al, 2006), and the most frequently involved subsites were the tongue and the mandible (Schadel et al, 2019). Therefore, IPNs can be clinically misdiagnosed as other oral benign lesions, such as mucoceles, schwannomas, neurofibromas (Rocha et al, 2009), lymphangiomas, or fibrous hyperplasias, as the present case.…”

Extraneural Sclerosing Perineurioma of the Tongue

“…Indeed, only 13 cases (8 intraneural and 5 extraneural) were reported in a recent review of the literature. 3 Herein, we present a 51-year-old Caucasian male with a 6-month history of painless lump involving the posterior third of the tongue. He was healthy and denied trauma, history of tongue tumors, or previous local surgery.…”

“…Indeed, only 13 cases (8 intraneural and 5 extraneural) were reported in a recent review of the literature. 3…”

“…For the rarity of PN in the oral cavity, 3 otolaryngologists and oral surgeons might not be familiar with this tumor. When encountered in the oral cavity/tongue, presentation of PNs is not specific and soft tissue tumors most common at this site, as granular cell tumor and other benign PNSTs, are usually clinically considered.…”