Perineurioma of scalp in an infant: A case report with short review of literature

Abstract

Perineuriomas are rare benign peripheral nerve sheath tumor composed exclusively of perineurial cells. They have been classified into two main types according to their location – intraneural and extraneural (soft-tissue). Extraneural perineurioma are uncommon, found mostly in the soft tissue of the extremities and trunk, rare at other site. They mainly affect adults and have been sometimes described in children but are extremely rare in infants. We present a case of extraneural (soft-tissue) perineurioma of scalp in a 3-month-old infant, highlighting clinical, pathologic, and immunohistochemical features along with a discussion of the main differential diagnosis of this tumor. This is also the youngest case ever reported in the literature.

Nerve conduction assessment and magnetic resonance imaging for the diagnosis of localized hypertrophic neuropathy of the sciatic nerve and the lumbo-sacral plexus

“…Nevertheless, the term IP should be properly restricted to PNST of perineural cells [8]. According to their location, perineuriomas are classified into extra-neural (soft-tissue) or intraneural [12].…”

Cutaneous and Subcutaneous Perineuriomas in 2 Pediatric Patients

“…The youngest reported case of perineurioma occurred as an extraneural perineurioma on the scalp in an infant. 19 Only 1 soft tissue perineural MPNST has been reported in the pediatric population, arising on the face of an 11-year-old boy. In a case series of 11 pediatric perineuriomas, including extraneural and intraneural, there was no evidence of recurrence or metastasis at follow-up.…”