Perineural space invasion in cervical cancer (FIGO IB1-IIB) accompanied by high-risk factors for recurrence

Skręt-Magierło, Joanna; Soja, Paweł; Kruczek, Andrzej; Kaznowska, Ewa; Wicherek, Lukasz

doi:10.4103/0973-1482.138126

Cited by 12 publications

(13 citation statements)

References 18 publications

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“…The occurrence of PNI was reported between 7 and 41.7% in previous studies investigating PNI in uterine cervical cancer (3)(4)(5)(6)(7). PNI is predicted to reduce the survival rate of cervical cancer patients (8)(9)(10). Thus, elucidating the mechanism of PNI and identifying markers for its early prediction are of great value for patients with early recurrence or metastasis of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer

et al. 2020

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Perineural invasion (PNI) has guiding significances for nerve preservation in cervical cancer, but there is no definite marker indicating PNI. Two cervical cancer cell lines (HeLa and ME-180) showed significant abilities to migrate along neurites in vitro and in vivo. Morphological observation revealed that Schwann cells (SC) arrived at the sites of cervical cancer cells before the onset of cancer metastasis. We used high-throughput antibody array to screen the signals mediating the interaction of nerve cells and cancer cells and found the high expression of CCL2 in dorsal root ganglion (DRG). Meanwhile, serum CCL2 showed a notable raise especially in cervical adenocarcinoma. SC-derived CCL2 bound to its receptor CCR2 and promoted the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of cervical cancer cells. In turn, cancer cell-derived signals triggered the expression of metalloproteinases (MMPs) including MMP2, MMP9, and MMP12 in SCs, promoting SCs to dissolve matrix. These data demonstrated that the cancer-nerve crosstalk formed a tumor microenvironment (TME) that facilitated to PNI. We identified the CCL2/CCR2 axis as a potential marker to predict the PNI and affect the nerve preservation for cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer

et al. 2020

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“…Additionally, it has been reported that the incidence of PNI in pancreatic, head and neck, prostate, gastric cancers is 98, 80, 75, and 60%, respectively (1). The incidence of PNI in cervical cancer is relatively lower than that in the aforementioned cancer types, which may be explained by extensive nerves around these tumor tissues and the strong interaction between these tumors and surrounding nerves (16). Previous studies have explored the molecular mechanisms underlying PNI associated with tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Univariate analysis suggested that parametrial PNI was one of the independent prognostic factors, and the risk of recurrence in cervical cancer patients with parametrial PNI was 2.5 times higher than that in cervical cancer patients with negative PNI. However, Skręt-Magierlo et al (16) reported that parametrial PNI was associated with clinical stage, depth of cervical stromal invasion, and tumor size, but not associated with parametrial invasion, lymph node metastasis, LVSI, and recurrence-free survival. The association between parametrial PNI and clinical stage, tumor invasion depth, tumor size, and lymph node metastasis was not conducted in the present study due to the small number of parametrial PNI.…”

Section: Discussionmentioning

confidence: 99%

“…Given that PNI of cervical cancer is associated with poor prognosis of cervical cancer patients, NSRH should be carefully recommended for cervical cancer patients with PNI. Skręt-Magierlo et al (16) suggest that frozen section examination of uterine nerves should be conducted in the surgery for cervical cancer patients who exhibited high-risk factors such as tumor size ≥4 cm, cervical stromal invasion depth ≥1.5 cm, or pelvic or para-aortic lymph node metastasis (16). NSRH can be conducted if PNI was not identified based on frozen section examination.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the association between perineural invasion and clinical and histopathological features of cervical cancer

Wei

Yao

Liu

2016

Molecular and Clinical Oncology

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Abstract. Perineural invasion (PNI) has been investigated as a new prognostic factor in a number of carcinomas. However, studies on PNI in cervical cancer are limited, and inconsistent conclusions have been reported by different groups. The aim of the present study was to analyze the relationship between perineural invasion (PNI) and clinical and histopathological features of cervical cancer, and to evaluate the clinical significance of PNI of cervical cancer. Retrospective review identified 206 patients with cervical cancer who underwent radical hysterectomy plus pelvic lymphadenectomy between December 2012 and August 2014. The association between PNI and clinical and histopathological features of cervical cancer and post-operative radiotherapy was evaluated based on univariate and multivariate analyses. PNI of cervical cancer was identified in 33 of 206 (16%) cervical cancer patients. Univariate analysis demonstrated that PNI was associated with clinical stage, tumor grade, tumor size, depth of invasion, lymphovascular space invasion (LVSI), and lymph node metastasis (P<0.05), but not associated with age and histopathological types (P>0.05). Multivariate analysis suggests that LVSI and lymph node metastasis were associated with PNI of cervical cancer (P<0.05). In addition, post-operative radiotherapy was significantly more recommended for patients with PNI than those without PNI (P<0.001). In conclusion, PNI of cervical cancer is associated with LVSI and lymph node metastasis and can be used as an index for the determination of post-operative radiotherapy for cervical cancer patients.

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“…PNI has been detected in 7.0-35.1% of patients with cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy (5,(17)(18)(19)(20)(21)(22)(23) (Table I). This histological finding significantly correlates with deep cervical invasion (5,17,18,(23)(24)(25)(26), lymph-vascular space invasion (LVSI) (5,19,20,23,26), large tumor size (5,19,23,25,26), tumor extension to the uterus (19,24), positive resection margins (26), parametrial invasion (19,20,22,23,26), lymph node metastases (5,17,23,26), and more advanced stage (5, 17-19, 25, 26). Meinel et al (18) found that PNI was also PNI had a higher chance to receive adjuvant radiotherapy or concurrent chemoradiation after surgery (5,19,20,23,27).…”

Section: Carcinoma Of the Uterine Cervixmentioning

confidence: 96%

Is Perineural Invasion a Novel Prognostic Factor Useful to Tailor Adjuvant Treatment in Patients Treated With Primary Surgery for Cervical and Vulvar Carcinoma?

et al. 2020

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Perineural invasion (PNI) is detected in 7.0-35.1% of cervical carcinomas. This histological finding correlates with cervical invasion, lymph-vascular space invasion (LVSI), tumor size, positive resection margins, parametrial invasion, node metastases and advanced stage. Some authors have reported that PNI has no prognostic relevance, others have found that PNI is related to disease-free survival or overall survival (OS) at univariate analysis, and others have observed that it is an independent poor prognostic factor for OS. The evaluation of PNI status should be included in the decisionmaking process for planning adjuvant treatment. PNI has been found in 7.6-52.4% of vulvar carcinomas. This feature, which is strongly associated with depth of invasion, LVSI, tumor size, advanced stage and nodal involvement, is an independent prognostic variable for the risk of recurrence and death in most series. PNI should be evaluated routinely in histopathology reports of vulvar carcinoma and could help clinicians to tailor adjuvant treatment.

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Perineural space invasion in cervical cancer (FIGO IB1-IIB) accompanied by high-risk factors for recurrence

Abstract: We were able to correlate parametrial PSI with the depth of invasion, tumor size and more advanced stage of the disease in early-stage cervical cancer with high-risk of recurrence. No association with a worse prognosis was observed.

Cited by 12 publications

References 18 publications

Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer

Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer

Evaluation of the association between perineural invasion and clinical and histopathological features of cervical cancer

Is Perineural Invasion a Novel Prognostic Factor Useful to Tailor Adjuvant Treatment in Patients Treated With Primary Surgery for Cervical and Vulvar Carcinoma?

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