“…Similarly to other authors, we found that PNI was associated with more advanced stages [ 46 , 48 , 49 ], larger tumors [ 45 , 49 ], greater DOI [ 41 , 45 ], greater lymph node involvement [ 45 , 48 , 50 ], and LVI [ 45 , 46 , 48 , 49 ]; these features suggest that the presence of PNI is associated with more aggressive biological behavior.…”