Perineural invasion and expression of nerve growth factor can predict the progression and prognosis of oral tongue squamous cell carcinoma

Shen, Wei; Wang, Yi Ping; Chang, Julia Yu Fong; Yu, Shu-Guang; Chen, Hsin Ming; Chiang, Chun-Pin

doi:10.1111/jop.12133

Cited by 49 publications

(46 citation statements)

References 29 publications

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“…The exact incidence of PNI in any study depends largely on the technique used and the definition by which the pathologist identifies PNI. To illustrate this point, Shen et al found an increase in detection of PNI from 22% to 51% in the same set of pathologic specimens when anti‐S‐100 immunostaining was performed in addition to hematoxylin‐eosin stains.…”

Section: Discussionmentioning

confidence: 97%

Adjuvant radiotherapy for early head and neck squamous cell carcinoma with perineural invasion: A systematic review

2015

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Perineural invasion (PNI) is widely regarded as a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). Treatment guidelines recommend adjuvant radiotherapy (RT) for patients with adverse pathologic features, including PNI. The purpose of this study was to systematically review the literature to determine if patients with PNI as their only indication for adjuvant therapy benefit from adjuvant RT. In total, 339 abstracts were reviewed for relevance leaving 85 articles, which were evaluated in detail. Thirteen retrospective studies addressed the role of adjuvant RT for patients with PNI. Evidence is lacking to recommend adjuvant RT for all patients with HNSCC with PNI. However, the literature suggests that large nerve or multifocal PNI may predict worse outcome and may be a more appropriate indication for adjuvant therapy. We advocate that patients decide whether to undergo adjuvant therapy after a discussion of the limitations of current evidence. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2350-E2357, 2016.

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Section: Discussionmentioning

confidence: 97%

Adjuvant radiotherapy for early head and neck squamous cell carcinoma with perineural invasion: A systematic review

2015

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“…5C, 5I) (Alexander et al 2013;Friedl and Alexander 2011). Perineural invasion is a feature that is also observed in malignant squamous cell carcinomas of, for example, the esophagus , skin (Adams et al 2014), tongue (Shen et al 2014) and oral cavity (Chatzistefanou et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Expression of the Ly6/uPAR-Domain Proteins C4.4A and Haldisin in Non-Invasive and Invasive Skin Lesions

Kriegbaum

Clausen

Lærum

et al. 2014

J Histochem Cytochem.

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C4.4A and Haldisin belong to the Ly6/uPAR/α-neurotoxin protein domain family. They exhibit highly regulated expression profiles in normal epidermis, where they are confined to early (C4.4A) and late (Haldisin) squamous differentiation. We have now explored if dysregulated expressions occur in non-invasive and invasive skin lesions. In non-invasive lesions, their expression signatures were largely maintained as defined by that of normal epidermis. The scenario was, however, markedly different in the progression towards invasive squamous cell carcinomas. In its non-invasive stage (carcinoma in situ), a pronounced attenuation of C4.4A expression was observed, but upon transition to malignant invasive squamous cell carcinomas, the invasive fronts regained high expression of C4.4A. A similar progression was observed for the early stages of benign infiltrating keratoacanthomas. Interestingly, this transition was accompanied by a shift in the predominant association of C4.4A expression with CK1/10 in the normal epidermis to CK5/14 in the invasive lesions. In contrast, Haldisin expression maintained its confinement to the most-differentiated cells and was hardly expressed in the invasive lesions. Because this altered expression of C4.4A was seen in the invasive front of benign (keratoacanthomas) and malignant (squamous cell carcinomas) neoplasms, we propose that this transition of expression is primarily related to the invasive process.

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“…Although shown as a predictor of recurrence, perineural invasion was not a predictor of death, as were both tumor volume and N classification. As previously reported, the latter was also a strong predictor of recurrence and death in our series.…”

Section: Discussionmentioning

confidence: 81%

Tumor volume as an independent predictive factor of worse survival in patients with oral cavity squamous cell carcinoma

et al. 2017

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Perineural invasion and expression of nerve growth factor can predict the progression and prognosis of oral tongue squamous cell carcinoma

Abstract: Anti-S-100 immunostaining is an effective technique to detect occult PNI. Both the positive PNI and NGF expression level are valuable biomarkers that can predict the progression of OTSCC and prognosis of OTSCC patients.

Cited by 49 publications

References 29 publications

Adjuvant radiotherapy for early head and neck squamous cell carcinoma with perineural invasion: A systematic review

Adjuvant radiotherapy for early head and neck squamous cell carcinoma with perineural invasion: A systematic review

Expression of the Ly6/uPAR-Domain Proteins C4.4A and Haldisin in Non-Invasive and Invasive Skin Lesions

Tumor volume as an independent predictive factor of worse survival in patients with oral cavity squamous cell carcinoma

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