Perinerin, a Novel Antimicrobial Peptide Purified from the Clamworm Perinereis aibuhitensis Grube and Its Partial Characterization

Pan, Weidong; Liu, Xianghui; Ge, Feng; Han, Jiahong; Zheng, Tao

doi:10.1093/jb/mvh036

Cited by 53 publications

(30 citation statements)

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“…It has important applications in aquaculture [9] [10], fishing [11], and medical care [12], so the demand for P. aibuhitensis is high worldwide. However, the natural resources of P. aibuhitensis are depleting because of excessive harvesting and environmental degradation, so it has become F. Lv friendly.…”

Section: P Aibuhitensis Belongs To the Family Nereididae And Is Mainmentioning

confidence: 99%

“…

AbstractIn this study, the effects of different salinity levels (9,12,15,18,21,24,27,30, and 33) on the growth performance, body composition, antioxidant indexes of Perinereis aibuhitensis (initial average mass, 20.4 ± 0.3 mg) and total nitrogen in the substrate were investigated. The survival rate, specific growth rate, feed coefficient, and protein efficiency ratio under different salinity levels were measured.

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confidence: 99%

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Effect of Salinity on the Growth Performance, Body Composition, Antioxidant Indexes of Perinereis aibuhitensis and Total Nitrogen in the Substrate

Lv¹,

Nie²,

Yu³

et al. 2017

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In this study, the effects of different salinity levels (9,12,15,18,21,24,27,30, and 33) on the growth performance, body composition, antioxidant indexes of Perinereis aibuhitensis (initial average mass, 20.4 ± 0.3 mg) and total nitrogen in the substrate were investigated. The survival rate, specific growth rate, feed coefficient, and protein efficiency ratio under different salinity levels were measured. The results showed that the survival rate of P. aibuhitensis at the salinity level of 9 was significantly lower than that of P. aibuhitensis at other salinity levels (P < 0.05). However, the survival rate of P. aibuhitensis at other salinity levels was not significant (P > 0.05). On the basis of quadratic polynomial fitting of the relationship between salinity levels and the specific growth rate, feed coefficient, and protein efficiency ratio, it was concluded that 25.36 -25.9 is the most suitable salinity range for the growth performance of P. aibuhitensis. The main body composition (moisture, crude fat, crude protein, and ash content) was measured at different salinity levels. The results indicated that, with the increase in salinity, the moisture content of P. aibuhitensis decreased gradually; in contrast, the ash content increased gradually, as the salinity level increased. However, in the salinity range of 18 to 33, the difference in ash content was not significant (P > 0.05). Salinity had a significant influence on the crude protein content (P < 0.05), while it had no significant influence on crude body fat. Crude protein showed an increasing trend with the salinity increasing from 9 to 24, and decreased with the salinity increasing from 24 to 33. Antioxidant indexes such as superoxide dismutase, catalase, vo MDA content was as low as the antioxidant activity at the salinity level of 24; this means low in vivo contents of active oxygen free radicals and excellent growth performance. This conclusion is consistent with that for other growth indexes. The total nitrogen content of the substrate in which the P. aibuhitensis specimens were cultured for 60 days was higher than the total nitrogen in the soil. With an increase in salinity, the total nitrogen content first decreased and then increased, and the lowest value was observed at the salinity level of about 24.

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Section: P Aibuhitensis Belongs To the Family Nereididae And Is Mainmentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

Effect of Salinity on the Growth Performance, Body Composition, Antioxidant Indexes of Perinereis aibuhitensis and Total Nitrogen in the Substrate

Lv¹,

Nie²,

Yu³

et al. 2017

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“…A 51-amino acid highly basic and hydrophobic peptide perinerin from the marine clamworm Perinereis aibuhitensis is an organism that is extensively used as bait in fisheries and aquaculture. Perinerin, a peptide that is constitutively present in the marine worm and whose sequence appears to be novel among all know antimicrobial peptides, was active against Gram-negative and Gram-positive bacteria as well as fungi (Pan et al, 2004). Antimicrobials peptides were screening both genomic and mRNA transcripts from a number of different species of flatfish.…”

Section: Fig 6d Anthelminthic and Antibacterial Compoundsmentioning

confidence: 99%

Biologically active compounds from natural and marine natural organisms with antituberculosis, antimalarial, leishmaniasis, trypanosomiasis, anthelmintic, antibacterial, antifungal, antiprotozoal, and antiviral activities

Asif¹

2016

TANG [HUMANITAS MEDICINE]

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The biologically active compounds derived from different natural organisms such as animals, plants, and microorganisms like algae, fungi, bacteria and merine organisms. These natural compounds possess diverse biological activities like anthelmintic, antibacterial, antifungal, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. These biological active compounds were acted by variety of molecular targets and thus may potentially contribute to several pharmacological classes. The synthesis of natural products and their analogues provides effect of structural modifications on the parent compounds which may be useful in the discovery of potential new drug molecules with different biological activities. Natural organisms have developed complex chemical defense systems by repelling or killing predators, such as insects, microorganisms, animals etc. These defense systems have the ability to produce large numbers of diverse compounds which can be used as new drugs. Thus, research on natural products for novel therapeutic agents with broad spectrum activities and will continue to provide important new drug molecules.

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“…Arenicins completely kill E. coli within 5 minutes at a concentration of 5 μM probably by membrane permeabilization [98] (Table 2). A second annelid peptide, named perinerin, has been purified from the clamworm, Perinereis aibuhitensis [9]. Perinerin contains four cysteine residues forming two disulphide bridges with the most abundant amino acid being arginine [9].…”

Section: Conventional Ampsmentioning

confidence: 99%

Conventional and Unconventional Antimicrobials from Fish, Marine Invertebrates and Micro-algae

2010

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All eukaryotic organisms, single-celled or multi-cellular, produce a diverse array of natural anti-infective agents that, in addition to conventional antimicrobial peptides, also include proteins and other molecules often not regarded as part of the innate defences. Examples range from histones, fatty acids, and other structural components of cells to pigments and regulatory proteins. These probably represent very ancient defence factors that have been re-used in new ways during evolution. This review discusses the nature, biological role in host protection and potential biotechnological uses of some of these compounds, focusing on those from fish, marine invertebrates and marine micro-algae.

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Perinerin, a Novel Antimicrobial Peptide Purified from the Clamworm Perinereis aibuhitensis Grube and Its Partial Characterization

Cited by 53 publications

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Effect of Salinity on the Growth Performance, Body Composition, Antioxidant Indexes of Perinereis aibuhitensis and Total Nitrogen in the Substrate

Effect of Salinity on the Growth Performance, Body Composition, Antioxidant Indexes of Perinereis aibuhitensis and Total Nitrogen in the Substrate

Biologically active compounds from natural and marine natural organisms with antituberculosis, antimalarial, leishmaniasis, trypanosomiasis, anthelmintic, antibacterial, antifungal, antiprotozoal, and antiviral activities

Conventional and Unconventional Antimicrobials from Fish, Marine Invertebrates and Micro-algae

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