Perindopril‐induced lichenoid photodermatitis

Perindopril/Indapamide-Induced Photosensitivity

“…Perindopril has been implicated only in one case of lichenoid photodermatitis. 4 In a comprehensive and rigorous systematic review, associations between thiazides and phototoxicity are supported by low-quality evidence as determined with use of the GRADE system. 5 ACEI are not included in this review even in the section "association with very low evidence."…”

“…In addition, the lack of effective pharmacovigilance system and a publication bias toward publishing only extravagant cases in the medical literature may play a role. 4 Therefore, physicians and pharmacists should report photosensitivity reactions associated to drugs in order to better understand their association evidence and their true incidence. Considering the wide use of perindopril/indapamide combination in hypertensive population, clinicians and pharmacists should be aware of the possibility of adverse effects such as photosensitivity occurring during its use.…”

“…Perindopril has been implicated only in one case of lichenoid photodermatitis. 4 In a comprehensive and rigorous systematic review, associations between thiazides and phototoxicity are supported by low-quality evidence as determined with use of the GRADE system. 5 ACEI are not included in this review even in the section “association with very low evidence.” These findings may be explained in part that physicians are more likely to diagnose and subsequently report photosensitivity in newly marketed drugs, and less likely to report a case resulting from a known photosensitizer.…”