Perinatally infected adolescents living with human immunodeficiency virus (perinatally human immunodeficiency virus)

Cruz, Maria Letícia Santos; Cardoso, Claudete Aparecida Araújo

doi:10.5501/wjv.v4.i3.277

Cited by 18 publications

(11 citation statements)

References 54 publications

(61 reference statements)

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“…Since the discovery of highly active anti-retroviral therapy (HAART), there has been improvement in virology findings, thus HIV-1-infected children can grow and thrive properly [8][9][10]. Survival rate against HIV are increasing in children worldwide and it improves the quality of life in HIV-1-infected children [9][10][11][12][13][14][15][16][17].…”

Section: Resultsmentioning

confidence: 99%

Long-term outcome in fully treated HIV-infected children in West Java-Indonesia: gender differences

Alam¹,

Sumantri²,

Parwati³

et al. 2018

HIV & AIDS Review

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Introduction: Since the discovery of highly active anti-retroviral therapy (HAART), there is an improvement in virology findings, thus human immunodeficiency virus type 1 (HIV-1)-infected children can grow and thrive properly. Studies have showed successful treatments of HIV-1-infected children in limited resources are differed by gender. Material and methods: We enrolled children 2-< 15 years old, vertically transmitted, with good treatment adherence and condition, and minimal therapy duration of 6 months. The study has been approved by the Research and Ethics Committee. Results: One hundred and sixty-eight children were enrolled, 99 were excluded because of lack of adherence and loss to follow-up. As many as 70 children have met the inclusion criteria, 40 (57.1%) children were females, who started anti-retroviral therapy (ART) therapy at the median age of 8 (range, 2.0-14.0 years). When the therapy started, 45 (64.3%) children were moderately to severely symptomatic (WHO stage 3 or 4), and most of them were males. Meanwhile, boys had higher improvement outcome of CD4 with median 10.5% (r = 3-45.7; p = 0.030) and lower viral loads than girls, although all HIV viruses were detected below 20 copy/ml. There was no significant relevance between caregiver and the treatment success. Conclusions: Children in limited resources, especially boys, can achieve successful therapeutic outcome with good treatment adherence and taking medication regardless of the caregiver.

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Section: Resultsmentioning

confidence: 99%

Long-term outcome in fully treated HIV-infected children in West Java-Indonesia: gender differences

Alam¹,

Sumantri²,

Parwati³

et al. 2018

HIV & AIDS Review

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“…43 Moreover, the long-term use of HAART may be responsible for systemic alterations that affect the growth of these children. 5,7,12,13 On the other hand, HAART emerged as a solution to the deleterious effects caused by the virus by diminishing the circulating viral load. Parallel to this, the immunologic reconstitution induced by the use of antiretroviral agents, expressed by the increase in CD41 T lymphocytes, has allowed patients to be clinically more stable, with reductions in opportunist infections that could cause malnutrition.…”

Section: Discussionmentioning

confidence: 99%

“…12 Perinatally, HIV infected children also showed a growth deficit resulting in reduced height. 13 Stagi et al 14 stated that "the losses in stature accumulated throughout the total period of childhood and adolescence may contribute to the reduced final height" of perinatally HIV infected patients.…”

mentioning

confidence: 99%

“…Because these children had reduced bone mineral density, the use of HAART appeared to increase the complications as a result of the low bone mineral density. 13 Since this population is at a stage of growth and development, it is natural that these complications are potentially more severe than they are in adults. 15 Outpatient dental treatment of patients with HIV/AIDS was initially concentrated on diagnosis, epidemiology, and treatment of oral manifestations caused by immunodepression.…”

mentioning

confidence: 99%

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Craniofacial morphology of HIV-positive children and adolescents undergoing antiretroviral therapy: A pilot study

Watanabe

Ortega

Costa

et al. 2018

American Journal of Orthodontics and Dentofacial Orthopedics

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“…Global studies have revealed high rates of mental health challenges, as well as sexual and substance use risk behavior, among PHIV+ teens (Malee et al 2011 ; Mellins and Malee 2013 ; Elkington et al 2010 ). Neglect of the psychosocial and behavioral health needs of PHIV+ children may contribute to non-adherence to medication in adolescence, leading to higher viral loads and multi-drug-resistant mutations of the virus (Bucek et al 2016 ; Cruz and Cardoso 2015 ; Mellins et al 2011 ; Naar-King et al 2006 ). These are both individual and public health concerns.…”

Section: Introductionmentioning

confidence: 99%

Cultural Adaptation of an Evidence-Informed Psychosocial Intervention to Address the Needs of PHIV+ Youth in Thailand

et al. 2017

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Globally, pediatric HIV has largely become an adolescent epidemic. Thailand has the highest HIV prevalence in Asia (1.2%), with more than 14,000 children living with HIV. There is growing demand for evidence-based psychosocial interventions for this population that include health and mental health support and sexual risk reduction, which can be integrated into HIV care systems. To address this need, a multidisciplinary team of Thai and US researchers adapted an existing evidence-informed, family-based intervention, The Collaborative HIV Prevention and Adolescent Mental Health Program + (CHAMP+), which has been tested in multiple global trials. Using community-based participatory research methods, changes to the intervention curriculum were made to address language, culture, and Thai family life. Involvement of families, youth, and stakeholders in the adaptation process allowed for identification of salient issues and of program delivery methods that would increase engagement. Participants endorsed using a cartoon-based curriculum format for fostering discussion (as in CHAMP+ South Africa) given stigma around discussing HIV in the Thai context. The Thai version of CHAMP+ retained much of the curriculum content incorporating culturally appropriate metaphors and story line. Sessions focus on family communication, coping, disclosure, stigma, social support, and HIV education. This paper explores lessons learned through the adaption process of CHAMP+ Thailand that are applicable to other interventions and settings. It discusses how culturally informed adaptations can be made to interventions while maintaining core program components.

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Perinatally infected adolescents living with human immunodeficiency virus (perinatally human immunodeficiency virus)

Cited by 18 publications

References 54 publications

Long-term outcome in fully treated HIV-infected children in West Java-Indonesia: gender differences

Long-term outcome in fully treated HIV-infected children in West Java-Indonesia: gender differences

Craniofacial morphology of HIV-positive children and adolescents undergoing antiretroviral therapy: A pilot study

Cultural Adaptation of an Evidence-Informed Psychosocial Intervention to Address the Needs of PHIV+ Youth in Thailand

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