Perinatal western‐type diet and associated gestational weight gain alter postpartum maternal mood

Bolton, Jessica L.; Wiley, M; Ryan, Bailey; Truong, Samantha; Strait, Melva; Baker, Dana Lee; Yang, Nancy Y. C.; O’Connell, Thomas M.; Wroth, Shelley; Sánchez, Cristina; Swamy, Geeta K.; Newgard, Christopher B.; Kuhn, Cynthia M.; Bilbo, Staci D.; Simmons, Leigh Ann

doi:10.1002/brb3.828

Cited by 18 publications

(20 citation statements)

References 93 publications

(112 reference statements)

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“…Decreased striatal DA has also been observed in BALB/c mice, "poor mothers" that develop depressive-like behavior following pregnancy and delivery (Avraham et al 2017). Other work using the gestational stress (Leuner et al 2016) and high-fat diet (Bolton et al 2017) models of PPD further point to altered DA signaling in the NAc and other VTA targets. DA dysfunction would also be predicted in endocrine models of PPD since sex steroid hormones and stress hormones modulate the reward system and influence reward behavior (Brummlete and Galea 2010; Montoya et al 2014;Macoveanu et al 2016), but this hasn't been examined.…”

Section: The Reward System In Ppd: Animal Modelsmentioning

confidence: 94%

“…In another stress-based PPD model, exposure to early life stressful experience is utilized (Nephew et al 2017a). Recent attempts have also been made to develop models of maternal depression based on high-fat diet/obesity, another factor which increases risk for PPD (Perani et al 2015;Bolton et al 2017). Each of these models induces one or more critical aspects of postpartum depressive-like symptomology including behavioral despair, anhedonia, anxiety-like behavior, and/or impaired maternal care which like the human condition can negatively impact offspring neurodevelopment (Smith et al 2004;Champagne and Meaney 2006;Brummelte et al 2006;Babb et al 2014).…”

Section: Animal Models Of Ppdmentioning

confidence: 99%

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The maternal reward system in postpartum depression

Post

Leuner

2018

Arch Womens Ment Health

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The experience of motherhood is most often emotionally positive and rewarding, but for many new mothers suffering from postpartum depression (PPD) this is not the case. Preclinical and clinical research has sought to uncover brain changes underlying PPD in order to gain a better understanding of how this disorder develops. This review focuses on the mesolimbic dopamine system, particularly the ventral tegmental area-nucleus accumbens pathway which has been implicated in the regulation of critical functions disrupted in PPD including mood, motivation and mothering. Specifically, we discuss normative changes in the mesolimbic system during motherhood in both rodents and humans and how these are impacted in PPD. We also consider modulation of mesolimbic dopamine by the hypothalamic neuropeptide oxytocin and how oxytocin-dopamine interactions regulate mood and mothering during the postpartum period. In addition to providing an overview of reward mechanisms in PPD, our goal is to highlight open questions which warrant further research.

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Section: The Reward System In Ppd: Animal Modelsmentioning

confidence: 94%

Section: Animal Models Of Ppdmentioning

confidence: 99%

The maternal reward system in postpartum depression

Post

Leuner

2018

Arch Womens Ment Health

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“…The specific factors contributing to the greater risk of PAAD include the absence of the partner or family support, a previous history of mental disorder or domestic violence, alcohol abuse, occurrence of pregnancy complications, changes estradiol and progesterone, and high intake of processed foods with excess sugar and fat content [1, 6–8]. One recent investigation showed that the perinatal consumption of a Western-type diet induced postpartum mood disorders, as well as depression-like phenotype and anxiety-like behavior in mice [9].…”

Section: Introductionmentioning

confidence: 99%

Systematic review of the association between dietary patterns and perinatal anxiety and depression

Silva

Cobucci

Gonçalves

et al. 2019

BMC Pregnancy Childbirth

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Background Specific dietary factors contribute to greater risks of prenatal and postpartum anxiety and depression. This study aimed to systematically review and assess the evidence regarding the association between dietary patterns and perinatal anxiety and depression (PAAD). Methods A systematic search of the Latin American & Caribbean Health Sciences Literature (LILACS), PubMed, and Scopus databases for cross-sectional and cohort studies through April 2019 was conducted. The methodological quality of the studies was assessed using the Newcastle-Ottawa scale (NOS) and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework was used to assess the quality of evidence. Results Ten studies (six cohort and four cross-sectional) were included. All studies had good methodological quality. In these studies, the Western ( n = 10), healthy ( n = 9), and traditional ( n = 7) dietary patterns were examined. The healthy pattern was inversely associated with prenatal and postpartum anxiety and prenatal depression. The traditional Japanese dietary pattern, the traditional Indian-confinement dietary pattern, the United Kingdom traditional dietary and the traditional Brazilian dietary pattern were associated with a lower risk of prenatal depression, postpartum depression, prenatal anxiety and postpartum anxiety, respectively. There was no significant association between a Western dietary pattern and PAAD. The GRADE assessment suggested that the quality of the evidence was very low to low across all outcomes owing to the design, risk of bias, and small sample size. Conclusions There is no definitive evidence about the relationship between Western dietary patterns and perinatal anxiety and depression. However, it found an inverse association among the healthy dietary pattern and PAAD. Future studies will be required to better evaluate associations between meal patterns and PAAD. Such studies may provide new insights and assist in the development of new prevention and treatment strategies.

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“…Another study by Perani and colleagues showed that HFD prevented lactation-associated anxiolysis, with HFD-fed mouse dams showing an increase in the latency to enter the lit chamber of the light-dark box, and a decrease in the number of lit chamber entries [74]. Similarly, a study investigated the effects of various maternal diets in mice showed that intake of a diet high in fat and branched-chain amino acids reduced time spent in open arms on P8 [14]. In our studies, we failed to see robust effects of diet in the open field test.…”

Section: Effects Of Diet and Selective Breeding On Behavioral Profile Of Postpartum Damsmentioning

confidence: 97%

Influence of high energy diet and polygenic predisposition for obesity on postpartum health in rat dams

Leuthardt

Bayer

Rodríguez

et al. 2021

Preprint

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It is estimated that 30% of pregnant women worldwide are overweight or obese, which leads to adverse health effects for both the mother and child. Women with obesity during pregnancy are at higher risk for developing both metabolic and mental disorders, such as diabetes and depression. Numerous studies have used rodent models of maternal obesity to understand its consequences on the offspring, yet characterization of changes in the dams is rare, and most rodent models rely solely on a high fat diet to induce maternal obesity, without regarding genetic propensity for obesity. Here we present the influence of both peripartum high energy diet (HE) and obesity-proneness on maternal health using selectively-bred diet-resistant (DR) and diet-induced obese (DIO) rat dams. Outbred Sprague-Dawley rats were selected and bred according to their propensity to gain weight. From F1 onward, dams consuming a HE diet displayed higher body weight gain during pregnancy, and HE diet had a strong effect on meal patterns. Sensitivity to the hormone amylin was preserved during pregnancy, regardless of diet. After several rounds of selective breeding, dams from generation F3 were assessed for their postpartum physiology and behaviors. We observed strong diet and phenotype effects on gestational weight gain, with DIO-HE dams gaining 119% more weight than DR-chow. A high-resolution analysis of maternal behaviors on postpartum day 2 (P2) did not detect main effects of diet or phenotype, but a subset of DIO dams showed decreased pup-related behaviors. During a sucrose preference test (SPT) on P14, all DR dams consumed at least 70% sucrose, while a subset of DIO dams preferred water. In generation F6/F7 dams, effects on gestational weight gain persisted, and we observed a main effect of phenotype on SPT, with DIO-chow dams showing the lowest sucrose preference. Both DIO and DR dams consuming HE diet had severe postpartum liver lipidosis and exhibited reduced leptin sensitivity in the arcuate nucleus at the time of pup-weaning. These data demonstrate that both diet and genetic obesity-proneness have consequences on maternal health.

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Perinatal western‐type diet and associated gestational weight gain alter postpartum maternal mood

Cited by 18 publications

References 93 publications

The maternal reward system in postpartum depression

The maternal reward system in postpartum depression

Systematic review of the association between dietary patterns and perinatal anxiety and depression

Influence of high energy diet and polygenic predisposition for obesity on postpartum health in rat dams

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