Perinatal stroke in term infants with neonatal encephalopathy

Ramaswamy, Viraraghavan Vadakkencherry; Miller, Steven P.; Barkovich, A. James; Partridge, John Colin; Ferriero, Donna M.

doi:10.1212/01.wnl.0000129909.77753.c4

Cited by 103 publications

(63 citation statements)

References 14 publications

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“…40 On the basis of the mechanisms that can lead to arterial occlusion and known perinatal risk factors, the arterial occlusion in our patients could have taken place during 3 periods: 1) in later labor, 2) the intrapartum period, and 3) shortly after delivery, each period reflecting different risks factors. 13,20,41,42 In this study, we could not differentiate these periods. All infants underwent labor, none being born by prelabor cesarean Graph shows DWIs of a patient with an infarction within the PCA territory, showing severe HSI on day 3 (A) and mild-to-moderate HSI on day 10 (B).…”

Section: Figmentioning

confidence: 78%

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Evolution of Unilateral Perinatal Arterial Ischemic Stroke on Conventional and Diffusion-Weighted MR Imaging

Dudink¹,

Al-Nakib²,

Govaert³

et al. 2009

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Knowledge of the sequence of signal-intensity (SI) changes on conventional and diffusion-weighted MR imaging (DWI) following perinatal arterial ischemic stroke (PAIS) is limited, adding to the difficulty in timing the onset of PAIS. We hypothesized that SI changes seen on early sequential MR imaging following PAIS should follow a similar time course. The aim of this study was to evaluate the time course of SI changes by using a simple classification that could be assessed visually from conventional imaging and DWI in term-born neonates with symptomatic unilateral PAIS.

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Section: Figmentioning

confidence: 78%

“…10,11 PAIS is occasionally associated with hypoxic-ischemic encephalopathy (HIE). 12,13 The timing of presentation is often Ͼ2 hours after birth and may be up to 3-4 days.…”

mentioning

confidence: 99%

Evolution of Unilateral Perinatal Arterial Ischemic Stroke on Conventional and Diffusion-Weighted MR Imaging

Dudink¹,

Al-Nakib²,

Govaert³

et al. 2009

AJNR Am J Neuroradiol

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“…1,2,25,26 It is worthy of note that the focal character distinguishes PAIS from hypoxic-ischemic encephalopathy, although these 2 pathological conditions share many risk factors and can coexist in the same patient. 26 Cord abnormalities (mainly tight umbilical cord) were associated with a nonsignificant increase in the likelihood of PAIS in this study. Lee et al 2 also reported a significant difference between PAIS and control subjects for cord abnormalities (22% versus 6%).…”

Section: Discussionmentioning

confidence: 99%

Antenatal Factors Associated With Perinatal Arterial Ischemic Stroke

Darmency-Stamboul

Chantegret

Ferdynus

et al. 2012

Stroke

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Background and Purpose-Perinatal arterial ischemic stroke (PAIS) is a common cause of hemiplegic cerebral palsy in children. The diagnosis of PAIS is based on cerebral imaging. The objective of our study was to determine prenatal risk factors associated with PAIS. Methods-A retrospective case-control study was nested in the whole population of Burgundy, France, from January 2000 to December 2007. Case patients were confirmed by review of brain imaging and medical records. Three control subjects per case were randomly selected from the study population by sex, term, place, and year of birth. Results-PAIS was confirmed in 32 patients and its incidence was one per 4400 live births.

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“…15 Perinatal arterial ischemic stroke has been reported to coincide with hypoxic-ischemic encephalopathy; hypoxic-ischemic encephalopathy has been suggested to be a risk factor for perinatal stroke. 16 Birth asphyxia can lead to congestion, endothelial injury, and intravascular coagulation, thus leading to stroke. 17 Hypoxic-ischemic encephalopathy is more often present in full-term infants than in preterm infants with stroke.…”

Section: August 2013mentioning

confidence: 99%

Risk Factors, Clinical Presentation, and Neuroimaging Findings of Neonatal Perforator Stroke

Ecury-Goossen

Raets²,

Lequin³

et al. 2013

Stroke

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Background and Purpose-To date, studies on neonatal stroke have mainly focused on cortical stroke. We have focused on perforator strokes, noncortical strokes in the arterial vascular perforator area. We sought to identify risk factors and evaluate clinical presentation and neuroimaging findings for neonatal perforator stroke, which seems to be under-recognized. Methods-All infants admitted to our tertiary intensive care unit in ≈12 years, whose perforator stroke was diagnosed with postnatal brain imaging, were enrolled in this study. Demographic, perinatal, and postnatal data were evaluated. Results-Seventy-nine perforator strokes were detected in 55 patients (28 boys), with a median gestational age of 37 1/7 weeks (range 24 1/7 to 42 1/7 weeks, 25 preterm). Perforator stroke was asymptomatic in most patients (58%). Initial diagnosis was predominantly made with cranial ultrasound (80%) in the first week of life (60%). Risk factors for stroke were present in all cases: maternal, fetal, and perinatal. Likely pathogenic mechanisms were prolonged birth asphyxia (16%), hypoxia or hypotension (15%), embolism (15%), infection (15%), acute blood loss (9%), and birth trauma (9%). Conclusions-Previously

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Perinatal stroke in term infants with neonatal encephalopathy

Cited by 103 publications

References 14 publications

Evolution of Unilateral Perinatal Arterial Ischemic Stroke on Conventional and Diffusion-Weighted MR Imaging

Evolution of Unilateral Perinatal Arterial Ischemic Stroke on Conventional and Diffusion-Weighted MR Imaging

Antenatal Factors Associated With Perinatal Arterial Ischemic Stroke

Risk Factors, Clinical Presentation, and Neuroimaging Findings of Neonatal Perforator Stroke

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