Perinatal protein malnutrition induces the emergence of enduring effects and age-related impairment behaviors, increasing the death risk in a mouse model

Ferroni, Nadina Micol; Berardino, Bruno Gabriel; Belluscio, Laura María; Fernández, María Soledad; Fesser, Estefanía A.; Sonzogni, Silvina V.; Cánepa, Eduardo T.

doi:10.1080/1028415x.2020.1829343

Cited by 2 publications

(2 citation statements)

References 54 publications

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“…Although all nutrients have influence on brain maturation, proteins appear to be the most critical components for the development of neurological functions. Experimental studies in rodents have shown that perinatal protein malnutrition could alter neurogenesis, cell maturation, synaptic plasticity and physical and neuromuscular development (Ferroni et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Ketogenic diet impairs neurological development of neonatal rats and affects biochemical composition of maternal brains: evidence of functional recovery in pups

Kosiek¹,

Zuzanna²,

Szulc³

et al. 2022

Brain Struct Funct

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The ketogenic diet (KD) is a type of diet in which the intake of fats significantly increases at the cost of carbohydrates while maintaining an adequate amount of proteins. This kind of diet has been successfully used in clinical therapies of drug-resistant epilepsy, but there is still insufficient evidence on its safety when used in pregnancy. To assess KD effects on the course of gestation and fetal development, pregnant females were fed with: (i) KD during pregnancy and lactation periods (KD group), (ii) KD during pregnancy replaced with ND from the day 2 postpartum (KDND group) and (iii) normal diet alone (ND group). The body mass, ketone and glucose blood levels, and food intake were monitored. In brains of KD-fed females, FTIR biochemical analyses revealed increased concentrations of lipids and ketone groups containing molecules. In offspring of these females, significant reduction of the body mass and delays in neurological development were detected. However, replacement of KD with ND in these females at the beginning of lactation period led to regainment of the body mass in their pups as early as on the postnatal day 14. Moreover, the vast majority of our neurological tests detected functional recovery up to the normal level. It could be concluded that the ketogenic diet undoubtedly affects the brain of pregnant females and impairs the somatic and neurological development of their offspring. However, early postnatal withdrawal of this diet may initiate compensatory processes and considerable functional restitution of the nervous system based on still unrecognized mechanisms.

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Section: Introductionmentioning

confidence: 99%

Ketogenic diet impairs neurological development of neonatal rats and affects biochemical composition of maternal brains: evidence of functional recovery in pups

Kosiek¹,

Zuzanna²,

Szulc³

et al. 2022

Brain Struct Funct

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show abstract

“…These results support previous studies. Thus, Berardino et al and Ferroni et al showed that a perinatal low-protein diet in mice was associated with memory deterioration in the offspring [ 54 , 55 ]. Wang et al found impairment of spatial learning and memory associated with decreased hippocampal brain-derived neurotrophic factor (BDNF) levels in rats after maternal low-protein diet during pregnancy [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction

et al. 2022

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Fetal growth restriction (FGR) has been linked to long-term neurocognitive impairment, especially in males. To determine possible underlying mechanisms, we examined hippocampal cellular composition and mTOR signaling of male rat FGR offspring during main brain growth and development (postnatal days (PND) 1 and 12). FGR was either induced by a low-protein diet throughout pregnancy, experimental placental insufficiency by bilateral uterine vessel ligation or intrauterine stress by “sham” operation. Offspring after unimpaired gestation served as common controls. Low-protein diet led to a reduced cell density in the molecular dentate gyrus subregion, while intrauterine surgical stress was associated with increased cell density in the cellular CA2 subregion. Experimental placental insufficiency caused increased mTOR activation on PND 1, whereas intrauterine stress led to mTOR activation on PND 1 and 12. To determine long-term effects, we additionally examined mTOR signaling and Tau phosphorylation, which is altered in neurodegenerative diseases, on PND 180, but did not find any changes among the experimental groups. Our findings suggest that hippocampal cellular proliferation and mTOR signaling are dysregulated in different ways depending on the cause of FGR. While a low-protein diet induced a decreased cell density, prenatal surgical stress caused hyperproliferation, possibly via increased mTOR signaling.

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Perinatal protein malnutrition induces the emergence of enduring effects and age-related impairment behaviors, increasing the death risk in a mouse model

Cited by 2 publications

References 54 publications

Ketogenic diet impairs neurological development of neonatal rats and affects biochemical composition of maternal brains: evidence of functional recovery in pups

Ketogenic diet impairs neurological development of neonatal rats and affects biochemical composition of maternal brains: evidence of functional recovery in pups

Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction

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