Perinatal Oxidative Stress and Kidney Health: Bridging the Gap between Animal Models and Clinical Reality

Tain, You‐Lin; Hsu, Chien‐Ning

doi:10.3390/antiox12010013

Cited by 5 publications

(7 citation statements)

References 144 publications

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“…Investigation of the potential mechanisms underlying renal programming has gained increasing attention [ 9 , 60 ]. Currently, the mechanisms accounting for renal programming include deficient NO [ 116 ], oxidative stress [ 2 , 117 ], the aberrant renin–angiotensin–aldosterone system (RAAS) [ 118 ], and gut microbiota dysbiosis [ 119 , 120 ]. The results of animal experiments indicate that the H 2 S signaling pathway interacts with the abovementioned mechanisms.…”

Section: Mechanisms Behind Protective Actions Of H 2 ...mentioning

confidence: 99%

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Sulfur-Containing Amino Acids, Hydrogen Sulfide, and Sulfur Compounds on Kidney Health and Disease

et al. 2023

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Hydrogen sulfide (H2S) plays a decisive role in kidney health and disease. H2S can ben synthesized via enzymatic and non-enzymatic pathways, as well as gut microbial origins. Kidney disease can originate in early life induced by various maternal insults throughout the process, namely renal programming. Sulfur-containing amino acids and sulfate are essential in normal pregnancy and fetal development. Dysregulated H2S signaling behind renal programming is linked to deficient nitric oxide, oxidative stress, the aberrant renin–angiotensin–aldosterone system, and gut microbiota dysbiosis. In animal models of renal programming, treatment with sulfur-containing amino acids, N-acetylcysteine, H2S donors, and organosulfur compounds during gestation and lactation could improve offspring’s renal outcomes. In this review, we summarize current knowledge regarding sulfide/sulfate implicated in pregnancy and kidney development, current evidence supporting the interactions between H2S signaling and underlying mechanisms of renal programming, and recent advances in the beneficial actions of sulfide-related interventions on the prevention of kidney disease. Modifying H2S signaling is the novel therapeutic and preventive approach to reduce the global burden of kidney disease; however, more work is required to translate this into clinical practice.

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Section: Mechanisms Behind Protective Actions Of H 2 ...mentioning

confidence: 99%

“…Methionine and cysteine are precursors of glutathione, which play a prominent role in oxidative stress [ 1 ]. It is known that oxidative stress is involved in the development of kidney disease [ 2 ]. Homocysteine is a non-protein-bound sulfur amino acid implicated in one-carbon metabolism and kidney disease [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Sulfur-Containing Amino Acids, Hydrogen Sulfide, and Sulfur Compounds on Kidney Health and Disease

et al. 2023

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“…As a well-known antioxidant, melatonin displays a protective role against oxidative stress by scavenging free-radicals and activating antioxidant enzymes [2]. A previous review revealed that several environmental stimuli in pregnancy linked oxidative stress to the developmental programming of kidney disease [85], covering maternal nutrition imbalance, maternal disorders, environmental chemical and toxin exposure, and medication use.…”

Section: Oxidative Stressmentioning

confidence: 99%

Melatonin and Kidney Health: From Fetal Stage to Later Life

Tang

Hsu

et al. 2023

IJMS

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Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring’s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.

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“…The kidneys are prone to oxidative stress [ 45 ]. This biomarker was chosen because of its role as a scavenger of free radicals and thus has a role in oxidative-stress-related renal diseases in neonates [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

Kamianowska,

Rybi-Szumińska,

Kamianowska

et al. 2024

Med Sci Monit

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Background Serum creatinine, the criterion standard in assessment of renal function, is not reliable for the neonatal period because of its dependence on renal immaturity and maternal creatinine levels. Thus, it is important to study other biomarkers of renal function in neonates. The present study aimed to measure the urinary concentration of renal biomarkers: calbindin, clusterin, GST-pi (glutathione-S-transferase-alpha), KIM-1 (kidney injury molecule 1), MCP-1 (monocyte chemoattractant protein-1), and B2M (beta 2-microglobulin) in healthy term neonates. Material/Methods In the study, we included 80 healthy term neonates – 40 females and 40 males. We collected the neonates’ urine on their first day of life. Urinary concentrations of calbindin, clusterin, KIM-1, MCP-1, and B2M were assessed using an immunoassay for kidney toxicology research. Because dilution of the urine affects the concentrations of urinary biomarkers, we normalized them to the concentration of urinary creatinine (Cr) and present them as biomarker/Cr ratios. Results We obtained the following values of the assessed biomarker/Cr ratios (median [Q1–Q3]): calbindin/Cr.: 197.04 (56.25–595.17), KIM-1/Cr: 0.09 (0.04–0.18), MCP-1/Cr: 0.05 (0.02–0.14), B2M/Cr: 126.12 (19.03–342.48), GST-pi/Cr in boys: 1.28 (0.46–3.77), GST-pi/Cr in girls: 8.66 (2.51–27.82), clusterin/Cr: 4.55 (1.79–12.97) ng/mg Cr. Conclusions We showed the urinary levels of calbindin, clusterin, GST-pi, KIM-1, MCP-1, B2M in white, West Slavic, healthy term neonates. We found that in there is an association between female sex and a higher urinary GST-pi excretion, but urinary excretion of calbindin, clusterin, KIM-1, MCP-1, and B2M is sex-independent. The urinary levels of the assessed biomarkers do not depend on the method of delivery.

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Perinatal Oxidative Stress and Kidney Health: Bridging the Gap between Animal Models and Clinical Reality

Cited by 5 publications

References 144 publications

Sulfur-Containing Amino Acids, Hydrogen Sulfide, and Sulfur Compounds on Kidney Health and Disease

Sulfur-Containing Amino Acids, Hydrogen Sulfide, and Sulfur Compounds on Kidney Health and Disease

Melatonin and Kidney Health: From Fetal Stage to Later Life

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

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