Perinatal outcomes of twin births conceived using assisted reproduction technology: a population-based study

Abstract

ART treatment was not a risk factor for adverse perinatal outcome, and risks for several outcomes were somewhat lower among ART twin deliveries. Nonetheless, ART is strongly associated with twinning and twins remain a high-risk group, relative to singletons. Promoting singleton gestation in assisted conception is an important strategy for reducing adverse outcomes.

Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment

“…We further provide one of a few studies of this size and diversity showing an association between the use of ovulation stimulation medications without ART and infants being born small for gestational age for singleton infants. Although the literature on twin outcomes is inconsistent, our study using a large population-based sample corroborates the findings of a number of studies that do not note any difference among outcomes of twin infants born after ART compared with spontaneously conceived twins (11,30,32). Our findings relative to ovulation stimulation-only twins were inconclusive.…”

Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies

“…Some of the complications have been attributed to a higher frequency of multiple births and to the increased risk of premature delivery; however, other reports indicate that also singleton IVF children have a greater risk of low birth weight and of congenital anomalies [8][9][10][11][12][13][14][15][16].…”

Mortalidad perinatal en gestaciones múltiples: Hospital Miguel Servet, Zaragoza, España: 2000-2009

“…Aunque se han publicado datos que refieren un aumento de las complicaciones y mortalidad en los múltiples procedentes de técnicas de reproducción asistida comparadas con las gestaciones de múlti-ples espontáneas (21), nosotros no hemos encontrado diferencias, coincidiendo con otros autores (9,22,23). Pero como la gestación múltiple implica riesgo en si misma, cada vez son más numerosas las voces que proclaman como ideal la transferencia de un solo embrión en las fecundaciones in vitro (23).…”

“…Pero como la gestación múltiple implica riesgo en si misma, cada vez son más numerosas las voces que proclaman como ideal la transferencia de un solo embrión en las fecundaciones in vitro (23).…”