Perinatal outcomes in singleton pregnancies with a single umbilical artery

Naveiro-Fuentes, Mariña; Badillo, María Paz Carrillo; Malde-Conde, Javier; Gallo-Vallejo, J.L.; Puertas, Alberto

doi:10.3109/14767058.2015.1053864

Cited by 12 publications

(13 citation statements)

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“…Tulek et al [11] analyzed birth weight and found that SGA was three-fold as likely in pregnancies with iSUA compared to pregnancies with TVC. Other recent studies also reported similar results [1317181920]. However, Bombrys et al [14] found that iSUA was not associated with a higher rate of SGA in comparison with newborns with TVC (13.7% vs. 13.9%, P =0.93).…”

Section: Discussionsupporting

confidence: 61%

“…These results suggest that the incidence of preterm birth in fetuses with iSUA was significantly higher than in fetuses with TVC, and iSUA increased the risk of any preterm birth (Fig. 3) [1113171820]…”

Section: Resultsmentioning

confidence: 99%

“…1. Table 1 shows the characteristics of the 11 included studies [1112131415161718192021]. The studies comprised 3 case-control studies and 8 cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“…Significant heterogeneity was found (chi 2 =17.18, P =0.009, I 2 =65%) (Fig. 4) [11121317181920], so random-effect model was used. The association between PIH and iSUA were seen in all meta-analyses.…”

Section: Resultsmentioning

confidence: 99%

“…SUA is defined as an isolated SUA (iSUA), if it occurs with no congenital abnormality in fetal chromosomes or structure [11]; In approximately 65% to 80% of SUAs, it appears to be iSUAs. In pregnancies with an iSUA, variable outcomes of aneuploidy, small for gestational age (SGA), preterm birth, pregnancy-induced hypertension (PIH), neonatal intensive care unit (NICU) admission, and perinatal mortality have been reported when compared with those fetuses and neonates with three vessel cords (TVC) [1112131415161718192021]. However, a controversy exists concerning whether iSUA is associated with adverse perinatal outcomes, with other studies presenting different views.…”

Section: Introductionmentioning

confidence: 99%

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Association of isolated single umbilical artery with perinatal outcomes: Systemic review and meta-analysis

Kim

Chay

et al. 2017

Obstet Gynecol Sci

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ObjectiveThe aim of this study was to evaluate the association between prenatally diagnosed isolated single umbilical artery (iSUA) and perinatal outcomes.MethodsWe searched Medline, Embase, the Cochrane Library, and KoreaMed from inception to January 2016, with no language or regional restrictions, for cohort and case-control studies reporting on the relationship of iSUA and perinatal outcomes. We assessed the odds ratios (ORs) and 95% confidence intervals (CIs) for the occurrence of small for gestational age, preterm birth, pregnancy-induced hypertension, neonatal intensive care unit admission, and perinatal mortality in fetuses with iSUA compared with those in fetuses with three vessel cord.ResultsEleven articles totaling 1,731 pregnancies with iSUA met the selection criteria. Studies varied in design, quality, outcome definition, and results. Meta-analysis carried out within predefined groups showed that the presence of an iSUA was associated with small for gestational age (OR, 2.75; 95% CI, 1.97 to 3.83; P<0.00001), preterm birth (OR, 2.10; 95% CI, 1.72 to 2.57; P<0.00001), pregnancy-induced hypertension (OR, 1.62; 95% CI, 1.00 to 2.63; P=0.05), neonatal intensive care unit admission (OR, 2.06; 95% CI, 1.33 to 3.19; P=0.001), and perinatal mortality (OR, 2.29; 95% CI, 1.32 to 3.98; P=0.003).ConclusionPregnancies complicated by iSUA are at increased risk for small for gestational age, preterm birth, pregnancy-induced hypertension, neonatal intensive care unit admission and perinatal mortality. Further, large prospective cohort studies are required to improve the quality of prenatal counseling and the neonatal care for pregnancies with iSUA.

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Section: Discussionsupporting

confidence: 61%

Section: Resultsmentioning

confidence: 99%

“…1. Table 1 shows the characteristics of the 11 included studies [1112131415161718192021]. The studies comprised 3 case-control studies and 8 cohort studies.…”

Section: Resultsmentioning

confidence: 99%