Perinatal outcomes in a large fetus born to nondiabetic patients

Baeva, I. Yu.; Константинова, О. Д.

doi:10.17116/rosakush201515464-68

Cited by 1 publication

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References 15 publications

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“…Low birth weight (LW) due to intrauterine growth retardation (IUGR), as well as premature birth (PB) has proven negative consequences for human development, quality of health in the future, life expectancy [2,3]. Babies who belong to the category of large fetus (LF), in addition to numerous abnormalities of hormonal and metabolic processes, often have traumatic injuries, are more likely to be born by cesarean section (CS) which also carries certain risks [4,5]. Both variants of deviations of intrauterine growth parameters increase the chances of developing obesity, diabetes mellitus, arterial hypertension in the next life, which is due to the depletion of adaptation mechanisms in early ontogenesis, and hence the formation of hypothalamic-pituitary-adrenal axis dysfunction with irreversible negative consequences [6,7].…”

Section: Introductionmentioning

confidence: 99%

Features of Reproductive Health of Women With Low Birth Weight and Overweight at Birth

Nestertsova

Nazarenko

2020

Technology transfer: innovative solutions in medicine

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The aim of the study was to clarify obstetric and perinatal risk in women born with low or overweight. Materials and methods. 343 women with birth weight abnormalities were examined. From them 3 groups are made, according to criterion “weight of the woman at a birth”: I – 107 women with low weight at a birth, II – 126 with excess, III – 110 people with normal weight. The anamnesis, in particular, family and own perinatal, as well as nutritional support, anthropometric data, the structure of pregnancy complications, the rate of growth and development of the fetus, perinatal results were determined. Levels of eicosapentaenoic and docosahexaenoic acids were determined as markers of nutritional support of the organism, as indicators of angiogenesis were determined – concentration of vascular endothelial growth factor and placental growth factor in blood, morpho-functional studies of placenta were performed. Results. Women born underweight are more likely to have menstrual disorders (every 4), infertility (every 10), miscarriage (every 5) and gynecological diseases. The pathology of gestation in such women and their mothers is similar in spectrum, which is an example of intrauterine programming. The implementation of this program is facilitated by negative factors of nutritional provision: inadequate breastfeeding, economical type of nutrition in favor of restricting protein foods and deviations in the process of angiogenesis. Conclusions. The importance of perinatal history as a factor that determines the increased risk of menstrual disorders, the frequency of infertility, the pathological course of gestation during pregnancy, the predisposition to placental insufficiency and the birth of a child with low weight. Women born with low birth weight and overweight are a contingent of increased perinatal risk, which is associated with a complicated own perinatal history on the background of obstetric pathology in their mothers. This fact complements the concept of intrauterine programming.

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