Perinatal Outcome of Oligohydramnios without Associated Premature Rupture of Membranes and Fetal Anomalies

Hsieh, T’sang‐T’ang; Hung, Tai-Ho; Chen, Kuang-Chao; Hsieh, Chia Chien; Lo, Lun Jou; Chiu, Tsung‐Hong

doi:10.1159/000009974

Cited by 20 publications

(25 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence was influenced by the population studied and the gestational age at the time of the ultrasound examination. In this study, the incidence of oligohydramnios was 0.89% (5,228/584,653), which was similar to the incidence (0.88%) reported between 1990 and 1996 in Taiwan (17). Previous studies have reported the short-term outcomes of pregnancies complicated by oligohydramnios (9-12).…”

Section: Discussionsupporting

confidence: 85%

“…Cases were selected if women had a diagnosis of oligohydramnios (ICD-9-CM: 658.0) in the third trimester of pregnancy, according to inpatient or outpatient claims. Ultrasonography is widely used in Taiwan to diagnose oligohydramnios during prenatal care because the amniotic fluid index is less than 5 cm (17). During a normal pregnancy, the amount of amniotic fluid typically increases until the sixth month and then slightly decreases during the eighth and ninth months (34).…”

Section: Patient Selectionmentioning

confidence: 99%

See 1 more Smart Citation

Oligohydramnios increases the risk of respiratory hospitalization in childhood: a population-based study

et al. 2013

View full text Add to dashboard Cite

Background: Pulmonary hypoplasia is associated with reduced lung function in infancy. The aim of this study was to evaluate the hypothesis that children exposed to oligohydramnios display an increased risk of hospitalization for respiratory illness by using a population-based matched-cohort design. Methods: We used three nationwide population-based data sets to identify 5,228 women who gave birth during 2004 to 2007 and were diagnosed with oligohydramnios during the third trimester of pregnancy. A cohort of 20,912 unaffected pregnant women was matched with these cases, according to neonatal sex and gestational age, maternal age and education, and level of prenatal care. Respiratory hospitalization and respiratory failure were defined using discharge diagnostic codes. results: Oligohydramnios-exposed children had an 8% higher incidence rate of respiratory hospitalization and an 80% higher incidence rate of respiratory failure, compared with children without oligohydramnios exposure. This risk remained after adjusting for all potential risk factors. Cox regression analyses indicated that the adjusted hazard ratios of respiratory hospitalization and respiratory failure were 1.07 (95% confidence interval (CI): 1.01-1.15; P = 0.030) and 2.20 (95% CI: 1.26-3.84; P = 0.005), respectively. conclusion: Children exposed to oligohydramnios during the third trimester of pregnancy display an increased risk of hospitalization for respiratory illness. P ulmonary hypoplasia is uncommon in the perinatal period but is a critical cause of death in newborn infants. Oligohydramnios is one of the abnormalities most commonly associated with pulmonary hypoplasia (1). Lung growth is influenced by physical factors such as the intrauterine space, lung liquid volume and pressure, and breathing movements. For lungs to develop, the physical space in the fetal thorax must be adequate, and amniotic fluid must be drawn into the lungs through fetal breathing movements, leading to their distension. Physical forces play vital roles in regulating fetal lung growth and maturation (2,3). During lung development, the main physical force experienced by the lung is stretching induced by breathing movements and lung fluid in the air spaces (4). Oligohydramnios reduces the intrathoracic cavity size, disrupting fetal lung growth and leading to the development of pulmonary hypoplasia (5,6).Oligohydramnios is a critical factor affecting short-and long-term clinical prognoses. In a study by Lindner et al. (7), neonates exposed to oligohydramnios experienced shortterm respiratory morbidity (including high ventilator settings, increased incidence of hypoxemia and hypercapnia, and pulmonary hypertension) and tended to experience more air leaks than did healthy neonates. Pulmonary hypoplasia is also associated with reduced lung function in infancy (8). Previous studies have reported the short-term perinatal outcomes of pregnancies complicated by oligohydramnios (9-12). A small case-control study found that infants born following the preterm rupture of membranes a...

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Patient Selectionmentioning

confidence: 99%

Oligohydramnios increases the risk of respiratory hospitalization in childhood: a population-based study

et al. 2013

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5] In addition to fetal urologic anomalies, such as renal agenesis or urethral obstruction, and rupture of membranes, oligohydramnios can be caused by uteroplacental insufficiency. Maternal diseases that cause vascular injury such as chronic hypertension, pregestational diabetes mellitus, and collagen vascular diseases are associated with decreased fetal renal perfusion, as are medications such as indomethacin, which inhibits formation of prostacyclin and PGE 2 , leading to decreased fetal renal blood flow and decreased fetal urine production.…”

Section: Introductionmentioning

confidence: 99%

An Amniotic Fluid Index ≤5 cm Within 7 Days of Delivery in the Third Trimester Is Not Associated with Decreasing Umbilical Arterial pH and Base Excess

2004

View full text Add to dashboard Cite

OBJECTIVE:To determine if an amniotic fluid index (AFI) r5.0 cm within 7 days of delivery in the third trimester is associated with decreasing umbilical arterial pH and base excess. STUDY DESIGN:Cases for this retrospective cohort study were all pregnancies Z26 weeks with intact membranes and an AFI r5.0 cm within 7 days of delivery between 11/99 and 7/02. Multiple gestations, aneuploid, and anomalous fetuses were excluded. Controls with an AFI >5.0 cm within 7 days of delivery were matched to each case within 1 week by gestational age. For a control group with a mean±SD umbilical arterial pH of 7.26±0.07 and a ¼ 0.05, a sample size of 100 would have a power of 99% to detect a difference with a study group whose mean was 7.20. Data were compared using paired Student's t-test, Mann-Whitney, Fisher's exact, w 2 and risk ratios with 95% confidence intervals. RESULTS:In all, 131 neonates with an AFI r5.0 cm were matched to 131 controls with an AFI >5 cm. There was no difference in gestational age (37.6±3.0, 37.7±3.0 weeks) or birth weight (2897±810, 2762±788 g). There was no difference in umbilical artery pH (7.25±0.07, 7.26±0.07) or base excess (À3.32±2.59, À2.83±2.45 mmol/l), even in small for gestational age (SGA) infants in both groups. There was no difference in the number of SGA neonates, 5-minute Apgar <7, respiratory distress syndrome, necrotizing enterocolitis, or neurologic morbidity. Linear regression showed no correlation between AFI and either umbilical arterial pH (r ¼ À0.00047, SE ¼ 0.001, p ¼ 0.63) or base excess (r ¼ À0.029, SE ¼ 0.037, p ¼ 0.428). CONCLUSION:An AFI r5.0 cm measured within 7 days of delivery in the third trimester is not associated with decreasing umbilical arterial pH and base excess.

show abstract

“…It is believed that oligohydramnios is a risk factor for the outcome of pregnancy, causing in many cases meconium staining, umbilical cord compression, fetal heart rate alterations, increased rate of cesarean section and other complications [2][3][4][5]. Amniotic fluid volume is a biophysical parameter with particular significance in high-risk pregnancies [6].…”

Section: Introductionmentioning

confidence: 99%

Use of Prostaglandin E2 for Cervical Ripening in Pregnancies with Oligohydramnios

Stefos¹,

Mouzakioti²,

Sotiriadis³

et al. 2000

Gynecol Obstet Invest

View full text Add to dashboard Cite

The effectiveness of intracervical prostaglandin E2 (PGE2) was studied in 96 primigravidas with unfavorable cervix and need for induction of labor. Group A consisted of 49 oligohydramnios and group B of 47 cases with normal amniotic fluid volume (controls). A single dose of 0.5 mg PGE2 gel was applied intracervically and several parameters were recorded during the next hours. The mean number of uterine contractions increased during the first 2 h in both groups, decreased during the next one and did not change significantly afterwards. The mean fetal heart rate (FHR) in group A decreased during the first 2 h and then increased, staying always within normal limits. The mean FHR in group B increased for 2 h, decreased during the next hour and did not change significantly afterwards. No significant differences were found between the two groups regarding mode of delivery, Apgar score and neonatal acidosis. Intracervical PGE2 appeared to effectively stimulate cervical ripening and labor induction in oligohydramnios, without causing side effects to the uterus and fetus.

show abstract

Perinatal Outcome of Oligohydramnios without Associated Premature Rupture of Membranes and Fetal Anomalies

Cited by 20 publications

References 14 publications

Oligohydramnios increases the risk of respiratory hospitalization in childhood: a population-based study

Oligohydramnios increases the risk of respiratory hospitalization in childhood: a population-based study

An Amniotic Fluid Index ≤5 cm Within 7 Days of Delivery in the Third Trimester Is Not Associated with Decreasing Umbilical Arterial pH and Base Excess

Use of Prostaglandin E2 for Cervical Ripening in Pregnancies with Oligohydramnios

Contact Info

Product

Resources

About