Perinatal Outcome of Children Born to Mothers with Thyroid Dysfunction or Antibodies: A Prospective Population-Based Cohort Study

Männistö, Tuija; Vääräsmäki, Marja; Pouta, Anneli; Hartikainen, Anna-Liisa; Ruokonen, Aimo; Surcel, Heljä‐Marja; Bloigu, Aini; Järvelin, Marjo‐Riitta; Suvanto-Luukkonen, Eila

doi:10.1210/jc.2008-1520

Cited by 243 publications

(140 citation statements)

References 23 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…Overt hypothyroidism affects pregnancy and neonatal outcomes in many ways. Many published studies have shown that overt hypothyroidism is associated with preterm labor, low birth weight, miscarriages, intrauterine embryo death and neurodevelopmental complications for the infant [25] [26] [27] [28] [29].…”

Section: Discussionmentioning

confidence: 99%

Subclinical Hypothyroidism and Isolated Hypothyroxinemia during Pregnancy and Their Association with Pregnancy Outcome: A 2-Year Study

Kalampoki¹,

Tsanadis²,

Stefos³

2017

OJOG

View full text Add to dashboard Cite

INTRODUCTION: Overt hypothyroidism in pregnancy is associated with adverse outcomes, but the effects of subclinical hypothyroidism and isolated hypothyroxinemia on pregnancy outcomes are still controversial. Subclinical hypothyroidism might be associated with preterm delivery, low Apgar score, fetal death and miscarriages and isolated hypothyroxinemia with preterm labor, high birth weight and neurocognitive deficits in children. Other studies show no association with any complications at all. In the present study we tried to estimate whether maternal subclinical hypothyroidism and isolated hypothyroxinemia are associated with complications during pregnancy in our population which represents the pregnant population of Western Greece. METHODS: In a total of 469 pregnant women, third trimester serum was assayed for thyroid-stimulating hormone (TSH) and free thyroxine (free T4). Thyroid hypofunction was defined as 1) subclinical hypothyroidism with TSH levels above 3 mIU/L for the 3 rd trimester and normal free T4 and 2) isolated hypothyroxinemia with TSH levels below 3 mIU/L for the 3 rd trimester and free T4 below the 5 th percentile. The results were associated with birth weight, week of labor, history of miscarriages and demographic characteristics. Patients with thyroid hypofunction were compared with euthyroid patients (TSH and free T4 between normal limits). The results were analyzed with one-way ANOVA and χ 2 test. RESULTS: Subclinical hypothyroidism was documented in 10.9% and isolated hypothyroxinemia in 21.7% of pregnant women. Subclinical hypothyroidism was not associated with birth weight, week of labor, or history of miscarriages. On the contrary, hypothyroxinemia was associated with high birth weight (P < 0.05). CONCLUSION: In our study, we did not find a link between subclinical hypothyroidism and adverse pregnancy outcomes. Similarly, hypothyroxinemia was not associated with pregnancy complications. However, it was associated with higher birth 694weight. Our studies contribute to our understanding, whether or not subclinical hypothyroidism and isolated hypothyroxinemia are associated with pregnancy adverse outcomes and whether treatment and test for hypothyroidism should become routine during pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Subclinical Hypothyroidism and Isolated Hypothyroxinemia during Pregnancy and Their Association with Pregnancy Outcome: A 2-Year Study

Kalampoki¹,

Tsanadis²,

Stefos³

2017

OJOG

View full text Add to dashboard Cite

show abstract

“…Furthermore, high TSH levels in women during pregnancy have been associated with an increased risk of neurocognitive deficits in the offspring (17). Other studies, however, have not found any adverse outcomes associated with SCH (18)(19)(20)(21). Moreover, there is uncertainty regarding the impact of levothyroxine replacement on improving outcomes in pregnant women with SCH (4).…”

mentioning

confidence: 99%

Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis

Maraka

Ospina

O’Keeffe

et al. 2016

Thyroid

288

203

View full text Add to dashboard Cite

Background: The impact of subclinical hypothyroidism (SCH) and of levothyroxine replacement in pregnant women with SCH is unclear. The aims of this study were to assess (i) the impact of SCH during pregnancy on maternal and neonatal outcomes, and (ii) the effect of levothyroxine replacement therapy in these patients. Methods: Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, the Cochrane Controlled Trials Register, Ovid EMBASE, Web of Science, and Scopus were searched from inception to January 2015. Randomized trials and cohort studies of pregnant women with SCH that examined adverse pregnancy and neonatal outcomes were included. Reviewers extracted data and assessed methodological quality in duplicate. Eighteen cohort studies at low-to-moderate risk of bias were included. Compared with euthyroid pregnant women, pregnant women with SCH were at higher risk for pregnancy loss (relative risk [RR] . One study at high risk of bias compared pregnant women with SCH who received levothyroxine to those who did not and found no significant decrease in the rate of pregnancy loss, preterm delivery, gestational hypertension, low birth weight, or low Apgar score. Conclusions: SCH during pregnancy is associated with multiple adverse maternal and neonatal outcomes. The value of levothyroxine therapy in preventing these adverse outcomes remains uncertain.

show abstract

“…[1][2][3][4][5] In 1999, interest in undiagnosed maternal thyroid dysfunction was heightened by studies suggesting an association between subclinical thyroid hypofunction and impaired fetal neuropsychological development. 6,7 In one report, children of women whose serum thyrotropin levels during pregnancy were greater than the 98th percentile had a lower IQ than children of matched controls who had a normal thyrotropin level.…”

mentioning

confidence: 99%

Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy

Casey

Thom

Peaceman³

et al. 2017

Obstetrical &Amp; Gynecological Survey

View full text Add to dashboard Cite

show abstract

Perinatal Outcome of Children Born to Mothers with Thyroid Dysfunction or Antibodies: A Prospective Population-Based Cohort Study

Abstract: First-trimester antibody positivity is a risk factor for perinatal death but not thyroid hormone status as such. Thyroid dysfunction early in pregnancy seems to affect fetal and placental growth.

Cited by 243 publications

References 23 publications

Subclinical Hypothyroidism and Isolated Hypothyroxinemia during Pregnancy and Their Association with Pregnancy Outcome: A 2-Year Study

Subclinical Hypothyroidism and Isolated Hypothyroxinemia during Pregnancy and Their Association with Pregnancy Outcome: A 2-Year Study

Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis

Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy

Contact Info

Product

Resources

About