Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis

Abstract

Objective: To evaluate the perinatal outcome of women with tuberculosis and to assess a possible association between maternal tuberculosis and long-term infectious morbidity of the offspring. Study design: Perinatal outcome and long-term infectious morbidity of offspring of mothers with and without tuberculosis were assessed. The study groups were followed until 18 years of age tracking infectious-related morbidity and infectious-related hospitalizations and then compared. For perinatal outcome, generalized estimation equation models were used. A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term infectious morbidity. A Cox proportional hazards model was conducted to control for confounders. Results: During the study period, 243,682 deliveries were included, of which 46 (0.018%) occurred in women with tuberculosis. Maternal tuberculosis was found to be independently associated with placental abruption, cesarean deliveries, and very low birth weight. However, offspring born to mothers with tuberculosis did not demonstrate higher rates of infectious-related morbidity. Maternal tuberculosis was not noted as an independent risk factor for long-term infectious morbidity of the offspring. Conclusion: In our study, maternal tuberculosis was found to be independently associated with adverse perinatal outcomes. However, higher risk for long-term infectious morbidity of the offspring was not demonstrated. Careful surveillance of these women is required.

Perinatal outcome and long‐term infectious hospitalizations of offspring born to women with known drug allergy

“…Data regarding those factors were lacking in our study. Other underlying conditions such as maternal obesity, 34 pervious maternal Tuberculosis, 35 and maternal celiac disease 36 may have affected our results since these conditions have all been previously found to be associated with increased long‐term infectious morbidity of the offspring. In addition, our study includes only hospitalized children.…”

Case Report: Congenital disseminated tuberculosis neonate born to tuberculosis- COVID-19 mother

“…Congenital TB could develop into meningitis TB with seizures as its primary symptoms; therefore we should consider the possibility of meningitis TB (12,14). Neonatal seizures, if prolonged and untreated, can cause permanent damage due to decreased oxygen flow and excessive brain cell EEG in a month-old male with congenital disseminated TB showed there was an electrical seizure.…”

“…Congenital TB is a fatal disease that must be diagnosed as early as possible to avoid devastating outcomes ( 2 – 4 ). In a newborn child, the clinical presentation of the disease is non-specific, which often delays the diagnosis ( 6 , 12 ). The transmission is most commonly from hematogenous spread via the umbilical vein, infected amniotic fluid aspiration, or ingestion of infected secretions ( 6 , 12 ).…”

“…In a newborn child, the clinical presentation of the disease is non-specific, which often delays the diagnosis ( 6 , 12 ). The transmission is most commonly from hematogenous spread via the umbilical vein, infected amniotic fluid aspiration, or ingestion of infected secretions ( 6 , 12 ). The primary complex in the liver, along with caseating granuloma, is the definitive lesion of congenital tuberculosis ( 2 – 4 ).…”

Tuberculosis in pregnancy

“…Although it can progress to active TB during pregnancy and postpartum, LTBI does not pose a risk of vertical transmission. As well, offspring born to mothers with TB did not demonstrate higher rates of infectious-related morbidity in the long term [ 97 ].…”