Perinatal or early-postnatal cytomegalovirus infection in preterm infants under 34 weeks gestation born to CMV-seropositive mothers within a high-seroprevalence population

Mussi-Pinhata, Marisa Márcia; Yamamoto, Aparecida Yulie; Rego, Maria Aparecida do Carmo; Pinto, Patrícia Cristina Gomes; Motta, M; Calixto, Cristina

doi:10.1016/j.jpeds.2004.07.025

Cited by 62 publications

(50 citation statements)

References 26 publications

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“…Other studies undertaken in other parts of the world have described the association between maternal seropositivity and CMV infection in newborns [24]. In Mexico, the population displays well-documented high CMV seropositivity.…”

Section: Discussionmentioning

confidence: 96%

Detection and gB genotyping of CMV in Mexican preterm infants in the context of maternal seropositivity

Arellano‐Galindo

Villanueva-García

Cruz-Ramirez

et al. 2014

J Infect Dev Ctries

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Introduction: Congenital (CI) and perinatal cytomegalovirus (CMV) infections (PI) can be linked to maternal CMV seropositivity, with fatal consequences in preterm newborns. GB genotyping has been used to analyze genotypic similarity in mothers and infants. The frequency of CMV infection in the context of maternal seropositivity and the viral gB genotypes as well as the genotypic similarity in mothers and preterm infants were investigated. Methodology: Saliva samples and dry blood spots (DBS) were taken weekly from preterm newborns from birth until the first month of life, and breast milk samples were taken from their mothers weekly during the first month of lactation. CMV IgG seroprevalence of the mothers and CI or PI in the infants were established. The gB status and genotypic similarities were established retrospectively in DBS and in the breast milk samples. Results: In total, 387 neonates and 375 mothers were enrolled. The maternal CMV-positive IgG serology was 97.3% (365/375). Neonatal CMV was found in 5.1% (20/387) of newborns, and one infant presented with CMV-compatible symptoms. CI was 2.5% and PI in the first month after birth was 11.8%. GB2 was the most prevalent genotype and was also the genotype preferentially transmitted to newborns by mothers with mixed infections. Conclusions: CMV PI and CI in preterm infants from highly seropositive mothers was high, but the rate of symptomatic infection was low. The prevalent genotype was gB2, and this genotype was preferentially transmitted to newborns by mothers with mixed infections.

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Section: Discussionmentioning

confidence: 96%

Detection and gB genotyping of CMV in Mexican preterm infants in the context of maternal seropositivity

Arellano‐Galindo

Villanueva-García

Cruz-Ramirez

et al. 2014

J Infect Dev Ctries

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“…In order to date the onset of infection, a review of the literature on the excretion of CMV in urine after primary infection was done. In a prospective study [23], the rate of early-postnatal CMV viruria in infants with median 31 weeks gestation (n=95) born to CMV-seropositive mothers without congenital CMV infection was 22%. Among these infected infants, the time of the first detection of CMV viruria ranged from 32 to 140 days (median 75 days).…”

Section: Discussionmentioning

confidence: 99%

“…Around 9-88% of seropositive mothers shed CMV into their milk, and approximately 50-60% of infants fed breast milk that contains the virus became infected [26,27]. A study on risk factors of early post-natal CMV infection revealed that receiving breast milk within the first 30 days (OR=4.5, p=0.02) or for greater than 30 days (OR=7.9, p＜0.01) were independently associated with CMV infection [23]. Birth weight, blood transfusion and vaginal delivery were not associated factors [23].…”

Section: Discussionmentioning

confidence: 99%

“…A study on risk factors of early post-natal CMV infection revealed that receiving breast milk within the first 30 days (OR=4.5, p=0.02) or for greater than 30 days (OR=7.9, p＜0.01) were independently associated with CMV infection [23]. Birth weight, blood transfusion and vaginal delivery were not associated factors [23]. In this study, no significant differences were observed between both groups regarding the educational background of parents, the rate of breastfeeding, the ratio of spontaneous delivery, and the number of siblings.…”

Section: Discussionmentioning

confidence: 99%

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Cytomegalovirus Infection in Infantile Hepatitis

2012

Pediatr Gastroenterol Hepatol Nutr

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“…Based on previous studies, "inactivated" milk, which is treated by freeze-storing or pasteurization, reduces or destroys the viral load [20][21][22] . In these studies, it is suggested that various transmission rates despite high rate of CMV DNA in breast milk might be associated with the method of breast milk preservation.…”

Section: Case Reportmentioning

confidence: 99%

Postnatal cytomegalovirus infection in an extremely premature infant transmitted via breast milk: A case report

et al. 2009

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= Abstract = Cytomegalovirus (CMV) is one of the most commonly encountered viral pathogens in newborn infants and is found in 0.3-2.4% of all live births. It has been demonstrated that 40-96% of seropositive mothers shed the virus via their breast milk. Breast milk containing CMV can cause almost one-third of CMV infections occurring in infants. A case of postnatal CMV infection in an extremely premature infant (gestational age 24 +5 weeks, birth weight 750 g) transmitted via breast milk is presented. For neonatal intensive care unit (NICU) management of severe thrombocytopenia, anemia, and sepsis syndrome, the infant received repeated transfusions of platelets; intravenous (IV) immunoglobulins; and gammairradiated, filtrated packed red cells and was fed her mother's breast milk since the second week of life. CMV infection was diagnosed with positive CMV immunoglobulin M (IgM) and positive urine CMV culture at the second month of life. Considering the negative CMV IgM and urine CMV culture at birth, postnatally-acquired CMV infection was suspected and confirmed with completely identical nucleotide sequence alignments of the infantile blood isolate and the maternal breast milk isolate. To our knowledge, this is the first case of proven postnatal CMV infection transmitted via breast milk in an extremely premature infant in Korea. (Korean J Pediatr 2009;52:1053-1058

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Perinatal or early-postnatal cytomegalovirus infection in preterm infants under 34 weeks gestation born to CMV-seropositive mothers within a high-seroprevalence population

Cited by 62 publications

References 26 publications

Detection and gB genotyping of CMV in Mexican preterm infants in the context of maternal seropositivity

Detection and gB genotyping of CMV in Mexican preterm infants in the context of maternal seropositivity

Cytomegalovirus Infection in Infantile Hepatitis

Postnatal cytomegalovirus infection in an extremely premature infant transmitted via breast milk: A case report

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