Perinatal management of newborns with haemophilia

Kulkarni, Roshni; Lusher, Jeanne M.

doi:10.1046/j.1365-2141.2001.02362.x

Cited by 110 publications

(81 citation statements)

References 68 publications

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“…Currently, recombinant factor FVIII concentrates are the most commonly used treatment. In patients with intracranial hemorrhage, factor replacement should be performed in such a way to increase the factor level to 100% and the treatment should be continued for 2-6 weeks 19 . Hemorrhage may need to be evacuated by surgical intervention in some cases as in our case 19 .…”

Section: Discussionmentioning

confidence: 99%

“…In patients with intracranial hemorrhage, factor replacement should be performed in such a way to increase the factor level to 100% and the treatment should be continued for 2-6 weeks 19 . Hemorrhage may need to be evacuated by surgical intervention in some cases as in our case 19 . In our patient who developed intracranial hemorrhage, coagulation parameters were normalized by fresh frozen plasma and afterwards the hematoma was evacuated by surgical intervention by the neurosurgery department.…”

Section: Discussionmentioning

confidence: 99%

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A newborn with moderate hemophilia A with severe intracranial and extracranial hemorrhage: A case report

Kader¹,

Reis²,

Mutlu³

et al. 2017

Dicle Tıp Dergisi

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Intracranial hemorrhage among term newborns is a rare clinical condition with high morbidity and mortality. Although major bleeding is relatively uncommon, the incidence of intracranial hemorrhage in hemophilic children is higher during the first few days of life than at any other stage in childhood, which relates to the trauma of delivery. Here, we reported a newborn case diagnosed with moderate hemophilia A, without the presence of a positive family history of hemophilia and presenting with intracranial and extracranial hemorrhage and we aimed to emphasize that the early diagnosis and replacement therapy carries an essential importance. Keywords: newborn, hemophilia A, intracranial hemorrhage, extracranial hemorrhage. Ağır intrakranial ve ekstrakranial kanaması olan orta hemofili Özetİntrakranial kanamalar term yenidoğanlarda nadir görülen, morbidite ve mortalitesi yüksek bir klinik tablodur. Majör kanamalar nispeten nadir olmasına rağmen, hemofilik çocuklarda yaşamın ilk birkaç gününde doğum travmasına bağlı gelişebilecek intrakranial kanama insidansı, çocukluğun herhangi bir evresine göre daha yüksektir. Burada, ailesinde hemofili öyküsü bulunmayan, intrakranial ve ekstrakranial hemoraji ile başvurup orta derecede hemofili A tanısı konan bir yenidoğan olgusunu sunmayı ve erken teşhis ve replasman tedavisinin hayati bir öneme sahip olduğunu vurgulamayı amaçladık.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A newborn with moderate hemophilia A with severe intracranial and extracranial hemorrhage: A case report

Kader¹,

Reis²,

Mutlu³

et al. 2017

Dicle Tıp Dergisi

View full text Add to dashboard Cite

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“…Subkutano cepljenje za zaščito pred okužbo z virusom hepatitisa B (HBV) je enako učinkovito kot vbrizgavanje v mišico (288). Če pa bi bilo cepljenje v mišico res nujno, sme hemofilik prejeti cepivo kmalu po ustreznem odmerku koagulacijskega faktorja VIII/ IX (289). Pred takim cepljenjem na predvideno mesto cepljenja za 5 minut položimo obkladek iz ledu (1).…”

Section: Cepljenje Oseb S Hemofilijounclassified

Nacionalna priporočila za obravnavo bolnikov s hemofilijo

et al. 2017

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The document presents recommendations for the comprehensive treatment of patients with haemophilia in Slovenia. It enables health workers at all three levels of health care to become well-acquainted with all the possible aspects of treatment based on the best practices of major centres worldwide, and on the studies and experience of health professionals at the National Haemophilia Centre, University Medical Center Ljubljana. The document contains definitions, treatment algorithms and lists of medications with their characteristics and appropriate dosages. It specifically defines indications for the exclusive competence of the tertiary level in Ljubljana due to the actual availability of teams and laboratory options. It also contains an extensive list of the literature on haemophilia.

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“…15 Haemophilic neonates not infrequently suffer bleeding intracranial haemorrhage or bleeding beneath the scalp, at the site of venepuncture, at the umbilical stump or after circumcision. 16 Although unchecked bleeding into the joints of neonates is uncommon, as the infant begins to crawl, unchecked hemarthrosis causes substantial and irreversible local damage. Therefore, a strong case for early prophylactic replacement of clotting factors, in the most severely affected, has been made.…”

Section: Prevention Is Better Than Curementioning

confidence: 99%