Perinatal low-protein diet alters brainstem antioxidant metabolism in adult offspring

Abstract

This study is the first to focus on the role of maternal LP nutrition in oxidative balance in a central nervous system structure responsible for cardiovascular control in adult rats. Our data observed changes in oxidative balance in the offspring, therefore, bring a new concept related to early undernutrition and can help in the development of a new clinical strategy to combat the effects of nutritional insult. Wherein the central oxidative imbalance is a feasible mechanism underlying the hypertension risk in adulthood triggered by maternal LP diet.

Maternal protein restriction induced‐hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata

“…Measurements of lipid peroxidation products, SOD catalytic activity and CAT catalytic activity were performed as previously described …”

Serotonin modulation in neonatal age does not impair cardiovascular physiology in adult female rats: Hemodynamics and oxidative stress analysis

“…The tissue was homogenized on ice and centrifuged at 1000 g for 10 min at 4°C. The supernatant was collected and stored at −20°C until assay [23,24].…”

Developmental Origins of Cardiometabolic Diseases: Role of the Maternal Diet

“…Ferreira and colleagues showed that perinatal protein undernutrition increased lipid peroxidation and decreased the activity of several antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities) as well as elements of the GSH system, in adult brainstem. Dysfunction in the brainstem oxidative metabolism, using the same experimental model, were observed in rats immediately after weaning associated to the increase in ROS production, with a decrease in antioxidant defense and redox status (Ferreira et al, 2015, 2016). Related to the metabolic effects on the heart, it was observed that these animals showed decreased mitochondrial oxidative phosphorylation capacity and increased ROS in the myocardium.…”

“…Feeding a low-protein diet (8% protein) during gestation and lactation is associated with growth restriction, asymmetric reduction in organ growth, elevated systolic blood pressure, dyslipidemia, and increased fasting plasma insulin concentrations in the most of studies in rodents (Ozanne and Hales, 2004; Costa-Silva et al, 2009; Falcão-Tebas et al, 2012; Fidalgo et al, 2013; Leandro et al, 2012; de Brito Alves et al, 2014, 2016; Ferreira et al, 2015; Paulino-Silva and Costa-Silva, 2016). However, it is known that the magnitude of the cardiovascular and metabolic outcomes are dependent on the both time exposure to protein restricted-diet (Zohdi et al, 2012, 2015) and growth trajectory throughout the postnatal period (Wells, 2007, 2011).…”