Perinatal lead and mercury exposure in Austria

Gundacker, Claudia; Fröhlich, Sonja; Graf-Rohrmeister, Klaudia; Eibenberger, Barbara; Jessenig, Verena; Gicic, Dijana; Prinz, Sebastian; Wittmann, Karl J.; Zeisler, Harald; Vallant, Birgit; Pollak, Arnold; Husslein, Peter

doi:10.1016/j.scitotenv.2010.07.079

Cited by 151 publications

(107 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mean age of the mothers was 29 years, the mean pre-pregnancy BMI was 23.1 kg/m 2 , the mean estimated gestational length was 39.7 weeks, 50% of women have at least university education, 53.8% of babies were males, and the mean birth length for all babies was 51.4 cm. The mean birth weight of the babies in our study was comparable with those reported elsewhere [23,30,35,38,45,46]. A total of 3.4% of the new-borns were below the criterion for "low birth weight" of 2,500 g [17], and 0.2% of new-borns were below 1,500 g, considered as a "very low birth weight" [47].…”

Section: Discussionsupporting

confidence: 86%

“…Studies investigating the effects of Cd exposure during pregnancy have been in conclusive: some studies [32][33][34] report negative associations, some positive [35], and others no association at all [36,37]. Exposure to Pb was found to be associated with birth weight either negatively [37,38], or insignificantly [34][35][36]. Non-significant correlations have been observed for Hg in maternal blood [35,36,39].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Birth Weight in Relation to Maternal Blood Levels of Selected Elements in Slovenian Populations: A Cross-sectional Study

Jagodic¹,

Tratnik²,

Mazej³

et al. 2017

JHS

View full text Add to dashboard Cite

Abstract:The objective of the present study was to evaluate the relation between maternal blood levels of selected toxic and potentially toxic elements (manganese (Mn), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), cadmium (Cd), lead (Pb) and mercury (Hg)) and birth weight of their new-borns in a Slovenian population, taking into account maternal socio-demographic characteristics and dietary habits. 535 women from 12 regions of Slovenia were recruited at delivery. Maternal blood was collected at 1.5 months after birth. Associations between birth weight and a) predictors obtained through the questionnaires and b) levels of selected elements were tested using bivariate tests and multiple linear regression. Multiple regression models revealed maternal age as an additional predictor for birth weight and confirmed pre-pregnancy body mass, estimated gestational age and gender of the baby as the main predictors for birth weight. Mn in maternal blood was significantly and positively associated with birth weight. The positive association observed between birth weight and Mn in maternal blood could be explained by the essentiality of Mn in foetal development as an important cofactor in enzyme reactions in bone formation and in metabolic regulation for amino acid, lipid, protein and carbohydrate levels.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Birth Weight in Relation to Maternal Blood Levels of Selected Elements in Slovenian Populations: A Cross-sectional Study

Jagodic¹,

Tratnik²,

Mazej³

et al. 2017

JHS

View full text Add to dashboard Cite

show abstract

“…Maternal age, height, pregnancy weight gain, socioeconomic background, lifestyle, and environmental exposure were identified as significant predictors. [14][15][16][17][18][19] Advancing maternal age, mothers with short stature, and poor weight gain during pregnancy were identified as contributing factors to smaller infant head circumference. [16][17][18] The aims of this study were to establish the trend of head circumference and incidence and predictors of microcephaly among Malaysian term newborns at the Universiti Kebangsaan Malaysia Medical Center (UKMMC) from 2011 to 2015.…”

mentioning

confidence: 99%

“…The limitation of our study lies in being unable to explore the relationship between head circumference and other important risk factors. For example, maternal pre-pregnancy and antenatal weight gain, socioeconomic position, dietary status, lifestyle, and environmental exposures such as smoking, alcohol, and lead exposure 14,15,19,[34][35][36][37] are important predictors of birth outcomes. The electronic birth census at our center was not designed to capture information on maternal activities and antenatal progression outside the hospital.…”

mentioning

confidence: 99%

Trend of head circumference as a predictor of microcephaly among term infants born at a regional center in Malaysia between 2011-2015

Sutan¹,

Yeong²,

Mahdy³

et al. 2018

RRN

View full text Add to dashboard Cite

“…8,9 Although the sensitive period remains undetermined, prenatal exposure to lead is of particular concern because lead is known to cross the placenta and cause adverse birth outcomes, such as preterm birth, low birth weight, and small for gestational age. 1,[10][11][12][13][14][15] Schell et al 12 found that maternal blood lead levels of $3 mg/dL during the second trimester were associated with reduced head circumference at 6 and 12 months, but had no significant effects at ,3 mg/dL. Afeiche et al, 16 in a follow-up study of attained child weight, found that prenatal maternal bone lead was associated with lower weight over time among girls up to 5 years of age.…”

mentioning

confidence: 99%

Postnatal Growth Following Prenatal Lead Exposure and Calcium Intake

Hong¹,

Kulkarni

Lim

et al. 2014

Pediatrics

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT:Lead is an ubiquitous environmental pollutant, and no safe threshold for blood lead level in children has been discovered yet. Prenatal lead exposure affects growth of children.WHAT THIS STUDY ADDS: Low level of prenatal lead exposure of ,5.0 mg/dL affects postnatal children' s growth, which was further intensified by low calcium intake. abstract BACKGROUND: The effects on postnatal growth of maternal exposure to low levels of lead during pregnancy have not been well established. In addition, information is limited regarding the protective effect of dietary calcium intake during pregnancy against the effect of lead for fetal and postnatal growth. We investigated the relationship between prenatal exposure to lead and growth at birth and 6, 12, and 24 months postnatal, and evaluated the role of calcium intake against the effect of lead. METHODS:A total of 1150 pregnant women, and their subsequent offspring, enrolled in a prospective birth cohort study (Mothers and Children' s Environmental Health Study), were evaluated. Multivariable regression analysis was conducted to estimate the effects of prenatal maternal blood lead levels on growth at each follow-up. RESULTS:The blood lead levels of participating mothers were ,5.0 mg/dL and mean levels were 1.25 mg/dL during the early (before 20 gestational weeks) and late (at delivery) gestational periods. Prenatal exposure to lead, particularly in late pregnancy, was significantly associated with a reduction in infantile growth at 24 months. When pregnant women had dietary calcium intake at mean or upper level, the association was not significant. In contrast, lower than mean level of calcium intake intensified the adverse effect of prenatal lead exposure on growth in children.CONCLUSIONS: Prenatal lead exposure ,5.0 mg/dL adversely affects postnatal growth and low calcium intake aggravates the effect, indicating more stringent control of lead and sufficient intake of calcium are necessary to help children' s health.

show abstract

Perinatal lead and mercury exposure in Austria

Cited by 151 publications

References 44 publications

Birth Weight in Relation to Maternal Blood Levels of Selected Elements in Slovenian Populations: A Cross-sectional Study

Birth Weight in Relation to Maternal Blood Levels of Selected Elements in Slovenian Populations: A Cross-sectional Study

Trend of head circumference as a predictor of microcephaly among term infants born at a regional center in Malaysia between 2011-2015

Postnatal Growth Following Prenatal Lead Exposure and Calcium Intake

Contact Info

Product

Resources

About