Perinatal imprinting by estrogen and adult prostate disease

Söder, Olle

doi:10.1073/pnas.0409703102

Cited by 10 publications

(6 citation statements)

References 11 publications

(12 reference statements)

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“…The concern about the exposure to EDCs has grown since the employment of these substances has increased over the years due to the development of society. Accordingly, humans are exposed to a great variety of these chemical agents, with either estrogenic 6–8 or androgenic 4,27 potential. The trenbolone acetate, for example, is a synthetic androgen that is often used to improve cattle growth.…”

Section: Discussionmentioning

confidence: 99%

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Prenatal testosterone exposure as a model for the study of endocrine-disrupting chemicals on the gerbil prostate

Biancardi

Perez

Góes

et al. 2012

Exp Biol Med (Maywood)

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The development of the prostate depends on a precise androgenic control, so sensible interferences may predispose this gland to develop prostatic diseases during life. These aspects are of interest and preoccupation, since human beings are exposed to a growing number of endocrine-disrupting chemicals with androgenic potential. Therefore, our aim was to evaluate the prostates of adult gerbils exposed to testosterone during intrauterine life. Serological, morphological, morphometric-stereologic, immunohistochemical and three-dimensional reconstruction analyses were used. We found that the testosterone effects were dose-dependent and more harmful to females, leading to the development of masculine characteristics, evidenced by an increased anogenital distance, and absence of vaginal opening and the ectopic development of prostatic tissue. Moreover, premalignant lesions, such as prostatic intraepithelial neoplasia, were observed in addition to inflammatory foci in the prostate. The results showed that the prenatal exposure to testosterone may affect the reproductive system, disrupting developmental processes and increasing susceptibility to the development of prostatic diseases in the Mongolian gerbil.

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Section: Discussionmentioning

confidence: 99%

“…The number of studies evaluating the effects of EDCs with estrogenic potential on the reproductive tract of rodents, especially on the prostate, has increased recently. 6–8 However, few studies have assessed the effects of intrauterine exposure to EDCs with androgenic potential on the prostate.…”

Section: Introductionmentioning

confidence: 99%

Prenatal testosterone exposure as a model for the study of endocrine-disrupting chemicals on the gerbil prostate

Biancardi

Perez

Góes

et al. 2012

Exp Biol Med (Maywood)

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“…This is an example of a concept of early nutrition that invariably impacts later health outcomes and is referred to as nutritional programming. Nutritional programming is used to explain a phenomenon in which a dietary exposure during a critical developmental period results in a permanent or long-term change in the structure or function of an organism [14,15,16]. Given that adiposity negatively regulates bone mineralization [17,18], a combination of both increased adiposity and suboptimal vitamin D status may constitute an inflammatory prone environment, causing poor offspring bone health, which can have lasting implications in adulthood.…”

Section: Introductionmentioning

confidence: 99%

Maternal Dietary Vitamin D Does Not Program Systemic Inflammation and Bone Health in Adult Female Mice Fed an Obesogenic Diet

et al. 2016

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Obesity is associated with systemic inflammation and impaired bone health. Vitamin D regulates bone metabolism, and has anti-inflammatory properties and epigenetic effects. We showed that exposure to high dietary vitamin D during pregnancy and lactation beneficially programs serum concentration of lipopolysaccharide (LPS) and bone structure in male offspring fed an obesogenic diet. Here we assessed if this effect is also apparent in females. C57BL/6J dams were fed AIN93G diet with high (5000 IU/kg diet) or low (25 IU/kg diet) vitamin D during pregnancy and lactation. Post-weaning, female offspring remained on their respective vitamin D level or were switched and fed a high fat and sucrose diet (44.2% fat, 19.8% sucrose) until age seven months when glucose response, adiposity, serum LPS, and bone mineral, trabecular and cortical structure, and biomechanical strength properties of femur and vertebra were assessed. There was no evidence for a programming effect of vitamin D for any outcomes. However, females exposed to a high vitamin D diet post-weaning had higher bone mineral content (p = 0.037) and density (p = 0.015) of lumbar vertebra. This post-weaning benefit suggests that in females, bone mineral accrual but not bone structure is compromised with low vitamin D status in utero until weaning in an obesogenic context.

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“…The fetal-origin hypothesis put forth by Dr. David Barker nearly three decades ago challenged the traditional views on the pathogenesis of common chronic diseases [ 1 ]. The Fetal-Origin Hypothesis, later termed the Developmental Origin of Health and Disease, established the principle that perinatal events are memorized by the developing organism through fetal and neonatal imprinting [ 2 ]. In light of this hypothesis, perinatal events can be thought of as the foundation for structural and functional development of an organism.…”

Section: Introductionmentioning

confidence: 99%

“…Some examples include soy isoflavones, bisphenol A, DDT, polychlorinated biphenyls, polybrominated diphenyl ethers, and a variety of phthalates. Although environmental estrogens pose minimal threat to adults, they may have an adverse effect on human health if exposure occurs during critical stages of development when cells are more easily influenced by steroid hormones [ 2 ]. Most of the supporting studies in this area have focused on a synthetic estrogen, diethylstilbestrol (DES).…”

Section: Introductionmentioning

confidence: 99%

The Interplay between Estrogen and Fetal Adrenal Cortex

Kaludjerovic

Ward

2012

Journal of Nutrition and Metabolism

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Estrogen is a steroid hormone that regulates embryogenesis, cell proliferation and differentiation, organogenesis, the timing of parturition, and fetal imprinting by carrying chemical messages from glands to cells within tissues or organs in the body. During development, placenta is the primary source of estrogen production but estrogen can only be produced if the fetus or the mother supplies dehydroepiandrosterone (DHEA), the estrogen prohormone. Studies show that the fetal zone of the fetal adrenal cortex supplies 60% of DHEA for placental estrogen production, and that placental estrogen in turn modulates the morphological and functional development of the fetal adrenal cortex. As such, in developed countries where humans are exposed daily to environmental estrogens, there is concern that the development of fetal adrenal cortex, and in turn, placental estrogen production may be disrupted. This paper discusses fetal adrenal gland development, how endogenous estrogen regulates the structure and function of the fetal adrenal cortex, and highlights the potential role that early life exposure to environmental estrogens may have on the development and endocrinology of the fetal adrenal cortex.

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Perinatal imprinting by estrogen and adult prostate disease

Cited by 10 publications

References 11 publications

Prenatal testosterone exposure as a model for the study of endocrine-disrupting chemicals on the gerbil prostate

Prenatal testosterone exposure as a model for the study of endocrine-disrupting chemicals on the gerbil prostate

Maternal Dietary Vitamin D Does Not Program Systemic Inflammation and Bone Health in Adult Female Mice Fed an Obesogenic Diet

The Interplay between Estrogen and Fetal Adrenal Cortex

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