Perinatal hypothyroidism effects on neuromotor competence, novelty-directed exploratory and anxiety-related behaviour and learning in rats

Darbra, Sònia; Garau, A; Balada, Ferran; Sala, J. J.; Martí-Carbonell, Maria Assumpció

doi:10.1016/s0166-4328(03)00041-x

Cited by 43 publications

(38 citation statements)

References 25 publications

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“…1b). These results are in agreement with other studies showing that a hyper and hypothyroid state can alter animal behavior (Redei et al, 2001;Smith et al, 2002;Darbra et al, 2003;Wilcoxon et al, 2007). Furthermore, perturbations in thyroid hormone function are associated with behavioral impairments in tasks requiring integrity of the hippocampus (Akaike et al, 1991;Darbra et al, 2004;Guadano-Ferraz et al, 2003;Sui et al, 2005).…”

Section: Discussionsupporting

confidence: 92%

“…THs are essential for normal maturation and function of the mammalian CNS (Oppenheimer & Schwartz, 1997;Santos & Pérez-Castillo, 2000;Darbra et al, 2003;Sui et al, 2005) and its deficiency, during a critical period of development, profoundly affects cognitive functions (Vara et al, *Address correspondence to this author at the Av. Protásio Alves, 7159/11 apto.…”

Section: Introductionmentioning

confidence: 99%

“…203 -Petrópolis, CEP 91310-003, Porto Alegre, RS, Brazil; Tel: 55 51 3012-8073; Fax: 55 51 3308 5540; E-mail: reis.lunardelli@gmail.com 2002; Dong et al, 2005). Hypothyroidism during human perinatal development results in profound alterations of mental capacities, neurological functions and metabolic processes (Darbra et al, 2003;Dong et al, 2005). The possibility of cognitive dysfunction, even in minor degrees of thyroid failure, has been pointed by some authors on the basis of neuropsychiatric consequences of myxedema in humans (Sher, 2001;Baldini et al, 1997;Monzani et al, 1993;Haggerty et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Thyroid Hormones on Memory and on Na+, K+-ATPase Activity in Rat Brain

Reis-Lunardelli¹,

Castro²,

Bavaresco³

et al. 2007

CNR

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Thyroid hormones (THs), including triiodothyronine (T3) and tetraiodothyronine (T4), are recognized as key metabolic hormones of the body. THs are essential for normal maturation and function of the mammalian central nervous system (CNS) and its deficiency, during a critical period of development, profoundly affects cognitive function. Sodium-potassium adenosine 5'-triphosphatase (Na(+), K(+)-ATPase) is a crucial enzyme responsible for the active transport of sodium and potassium ions in the CNS necessary to maintain the ionic gradient for neuronal excitability. Studies suggest that Na(+), K(+)-ATPase might play a role on memory formation. Moreover, THs were proposed to stimulate Na(+), K(+)-ATPase activity in the heart of some species. In this work we investigated the effect of a chronic administration of L-thyroxine (L-T4) or propylthiouracil (PTU), an antithyroid drug, on some behavioral paradigms: inhibitory avoidance task, open field task, plus maze and Y-maze, and on the activity of Na(+), K(+)-ATPase in the rat parietal cortex and hippocampus. By using treatments which have shown to induce alterations in THs levels similar to those found in hyperthyroid and hypothyroid patients, we aimed to understand the effect of an altered hyperthyroid and hypothyroid state on learning and memory and on the activity of Na(+), K(+)-ATPase. Our results showed that a hyper and hypothyroid state can alter animal behavior and they also might indicate an effect of THs on learning and memory.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Thyroid Hormones on Memory and on Na+, K+-ATPase Activity in Rat Brain

Reis-Lunardelli¹,

Castro²,

Bavaresco³

et al. 2007

CNR

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“…2006;Rovet 2002;Zoeller and Rover 2004). This is also supported experimentally, where developmental hypothyroidism causes the deficits in passive avoidance, spatial learning, and operant conditioning (Brosvic et al 2002;Darbra et al 2003Darbra et al , 2004, stunted growth, impaired brain development, and mental retardation (Anderson et al 2003;Bernal et al 2003;Goodman and Gilbert 2007;Mastorako et al 2007;Zoeller and Rover 2004).…”

Section: Introductionmentioning

confidence: 89%

Developmental Iodine Deficiency and Hypothyroidism Impair Spatial Memory in Adolescent Rat Hippocampus: Involvement of CaMKII, Calmodulin and Calcineurin

et al. 2009

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Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show that hippocampal calcium/calmodulin-dependent protein kinase II (CaMKII), calmodulin and calcineurin are implicated in the impaired spatial memory in adolescent rats following developmental ID and hypothyroidism. Three developmental rat models were created by administrating dam rats with either iodine-deficient diet or propylthiouracil (PTU, 5 or 15 ppm)-added drinking water from gestational day (GD) 6 till postnatal day (PN) 28. Then, the spatial memory to a water maze test was studied in pups before PN42. After testing periods, the latency to platform and the number of error in iodine-deficient and 15 ppm PTU-treatment groups were significantly higher than those in the controls (P < 0.05). Total and phosphorylated CaMKII, calmodulin, and calcineurin in the hippocampus were detected with both the immunohistochemistry and western blotting. Without going through water maze test, iodine-deficient and 15 ppm PTU-treatment groups showed significantly lower CaMKII and calmodulin and significantly higher calcineurin than the controls in hippocampal CA1 and CA3 regions (P < 0.05). After trials of water maze task, however, CaMKII and calmodulin were up-regulated and calcineurin was down-regulated in control group (P < 0.05), but not in iodine-deficient and 15 ppm PTU-treatment groups. Data indicate that hippocampal CaMKII, calmodulin, and calcineurin are involved in the impaired spatial memory induced by developmental ID and hypothyroidism.

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“…Previous studies have documented a decrease in the ability of neonatal hypothyroid animals to learn and to habituate to maze tests and an increase in spontaneous activity (Darbra et al, 2003). On the other hand some observers stated that children with hypothyroidism had no apparent specific impediments to learning unrelated to intelligence (England Congenital Hypothyroidism Collaborative New, 1990).…”

Section: Central Nervous System ıNvolvement Due To Hypothyroıdısmmentioning

confidence: 99%

Neurological Complications of Hypothyroidism

Türker¹,

Turker²,

Cengiz³

2012

Hypothyroidism - Influences and Treatments

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Perinatal hypothyroidism effects on neuromotor competence, novelty-directed exploratory and anxiety-related behaviour and learning in rats

Cited by 43 publications

References 25 publications

Effects of Thyroid Hormones on Memory and on Na+, K+-ATPase Activity in Rat Brain

Effects of Thyroid Hormones on Memory and on Na+, K+-ATPase Activity in Rat Brain

Developmental Iodine Deficiency and Hypothyroidism Impair Spatial Memory in Adolescent Rat Hippocampus: Involvement of CaMKII, Calmodulin and Calcineurin

Neurological Complications of Hypothyroidism

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